Original articleAlimentary tractPrevalence of Eosinophilic Esophagitis in the United States
Section snippets
Study Design, Data Source, and Case Definition
We performed a retrospective analysis of the IMS LifeLink PharMetrics Health Plan Claims Database (IMS Health Inc, Waterton, MA). This database contains longitudinal, integrated, fully adjudicated medical and pharmaceutical claims for more than 75 million individuals from more than 80 health plans and has been shown to be representative of a U.S. national commercially insured population.17, 18 Enrollees' demographic data including age, sex, and census region (East, South, Midwest, and West)
Characteristics of Eosinophilic Esophagitis Cases
A total of 35,575,388 individuals in the database from 2008-2011 with continuous enrollment of at least 6 months represented the initial source population. Of these, 16,405 had at least 1 code for 530.13 and comprised the EoE case group. These patients were an average of 33.5 years old, and 64.9% were male (Table 1). The mean number of 530.13 ICD-9 claims per case was 7.4 (median, 4), and the number of identified cases substantially increased between 2008 and 2009, likely indicating increasing
Discussion
During the past decade, EoE has emerged as a major cause of upper gastrointestinal morbidity in both children and adults.3, 5, 6, 7, 10, 11, 14, 19, 24, 25 However, estimates of the prevalence of EoE in the United States have been limited by fragmented medical record systems and a lack of validated or consistently applied disease definitions. The aim of this study was to characterize cases of EoE and estimate the prevalence of EoE in the United States in a large database with methodology not
Acknowledgements
The statements, findings, conclusions, views and opinions contained and expressed in this article are based in part on data obtained under license from the following IMS Health Incorporated information service: LifeLink PharMetrics Health Plan Claims Database (January 1, 2001 through November 30, 2011), IMS Health Incorporated. All Rights Reserved. The statements, findings, conclusions, views, and opinions contained and expressed herein are not necessarily those of IMS Health Incorporated or
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Conflicts of interest The authors disclose no conflicts.
Funding Supported in part by a University of North Carolina Junior Faculty Development Grant (E.S.D.) and NIH Awards K23 DK090073 (E.S.D.) and K08 DK088957 (M.D.K.).