Original article—alimentary tractPatients With Celiac Disease and B-Cell Lymphoma Have a Better Prognosis Than Those With T-Cell Lymphoma
Section snippets
Patients
Patients carrying the diagnosis of both CD and lymphoma were identified through the Mayo Clinic patient registry and the Mayo Clinic Lymphoma Database. Patients diagnosed with lymphoma in the period from 1970 to 2005 who also had a diagnosis of CD were included. Details of presenting history, physical examination, staging investigations, treatment, and clinical outcome were extracted from patient records. We collected information necessary to perform accurate lymphoma staging and to apply the
Patients and Clinical Presentation
Sixty-three patients carrying both a diagnosis of lymphoma and CD were identified. Thirty-six (57%) were men, and 27 (43%) were women. The median age at the time of diagnosis of lymphoma was 62 years (range, 11–91 y). The lymphoma diagnosis was confirmed from 1975 to 1985 in 16 (25%), from 1986 to 1996 in 22 (35%), and from 1997 to 2005 in 25 (40%) patients. Thirty-six (57%) patients had CD diagnosed before being diagnosed with lymphoma. Four (6%) patients were diagnosed with CD and lymphoma
Discussion
We describe a single-center experience of 63 patients with lymphoma and CD. We included all patients who were seen at the Mayo Clinic carrying a diagnosis of both lymphoma and CD regardless of the temporal relationship between these 2 disorders. A slight majority of patients had a pre-existing diagnosis of CD at the time of the lymphoma diagnosis, though all of the cases of ETL either had an established diagnosis of CD before the diagnosis of lymphoma or coincident with the diagnosis of
Acknowledgments
Current addresses of T.R.H.: Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa Hospitals and Clinics and Iowa City VA Medical Center, Iowa City, Iowa.
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Conflicts of interest The authors disclose no conflicts.
Funding This article was supported by the National Institutes of Health under the Ruth L. Kirschstein National Research Service Award/Training Grant in Gastrointestinal Allergy and Immunology (T32 AI-07047 to A.R.-T.) and National Institutes of Health grant DK-57892 (to J.A.M.).