Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1853, Issue 5, May 2015, Pages 1113-1118
ReviewDefective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy
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Abbreviations
DCM
Diabetic cardiomyopathy
T2DM
Type 2 diabetes mellitus
LV
Left ventricular
CAD
Coronary artery disease
HFD
High fat-diet
FA
Fatty acid
IRS1
Insulin receptor substrate 1
CIRKO
Cardiomyocyte-specific knockout of the insulin receptor
Mnf1
Dynamin-related GTPase mitofusin 1
Mnf2
Dynamin-related GTPase mitofusin 2
Opa-1
Optic atrophy protein 1
IMM
Inner mitochondrial membrane
OMM
Outer mitochondrial membrane
Fis1
Mitochondrial fission 1 protein
Drp1
Dynamin related protein 1
ROS
Reactive oxygen species
SOD
Superoxide dismutase
O-Glc-NAcylation
O-linked-β-N-acetylglucosamine modification
HF
Heart failure
mTOR
Mammalian target of rapamycin
NFκB
Nuclear factor kappa-light-chain-enhancer of activated B cells
Pink1
Serine/threonine kinase PTEN-induced putative kinase 1
Parkin
E3 ubiquitin ligase
AMPK
5′ AMP-activated protein kinase
Drp1-CKO
Cardiomyocyte-specific Drp1 knockout
T1DM
Type 1 diabetes mellitus
LAMP1
Lysosomal-associated membrane protein 1
IRS2
Insulin receptor substrate 2
CIRS12KO
Cardiomyocyte-specific deletion of both IRS1 and IRS2
Keywords
Insulin signaling
Diabetic cardiomyopathy
Mitochondrial dynamics
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