REVIEWRecent advances in the anti-HCV mechanisms of interferon
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open access
Graphical abstract
This review summarized pathways of interferon induction and regulation by HCV infection, and how interferon in turn triggers anti-HCV activities as well as control the outcome of HCV infection.
Key words
Interferon
Hepatitis C virus
Antiviral agent
Molecular mechanism
Abbreviations
CHC
chronic hepatitis C
DCs
dendritic cells
DNAM1
DNAX accessory molecule-1
dsRNA
double-stranded RNA
E2
envelop 2
GAS
IFN-γ-activated site
GWAS
genome-wide association studies
IFN
interferon
IFN-α
interferon-α
IFNAR1
interferon-alpha receptor 1
IFNAR2
interferon-alpha receptor 2
IFNGR1
interferon gamma receptor 1
IFNGR2
interferon gamma receptor 2
IFNL4
IFN-lambda 4
IL-10R2
interleukin-10 receptor 2
IL-29
interleukin-29
IRF-3
interferon regulatory factor 3
IRGs
IFN regulatory genes
ISG15
interferon-stimulated gene 15
ISGs
IFN-stimulated genes
ISGF3
IFN-stimulated gene factor 3
ISREs
IFN-stimulated response elements
JAKs
Janus activated kinases
MAVS
mitochondrial antiviral signaling protein
MDA-5
melanoma differentiation-associated gene-5
MHC
major histocompatibility complex
NKCs
natural killer cells
NKTCs
natural killer T cells
OAS
2′-5′-oligoadenylate synthetase
PAMPs
pathogen-associated molecular patterns
PBMCs
peripheral blood mononuclear cells
pDC
plasmacytoid dendritic cell
PKR
protein kinase R
PRRs
pattern recognition receptors
RdRp
RNA dependent RNA polymerase
RIG-I
retinoic acid-inducible gene-I
RLRs
RIG-I-like receptors
SNPs
single-nucleotide polymorphisms
SOC
standard of care
STAT1
signal transducer and activator of transcription 1
STAT2
signal transducer and activator of transcription 2
SVR
sustained virological response
TH1
T-helper-1
TH2
T-helper-2
TLRs
Toll-like receptors
TYK2
tyrosine kinase 2
USP18
ubiquitin specific peptidase 18
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Peer review under responsibility of Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.
Copyright © 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.