Annales de Dermatologie et de Vénéréologie
Original articleSyringoma: A clinicopathological study of 244 casesSyringomes : étude anatomoclinique de 244 cas
Section snippets
Patients and methods
This is a retrospective study concerning all of the samples submitted to the skin histology laboratory of the dermatology clinic at the university hospitals of Strasbourg between 1970 and 2008. Based on histological diagnosis of syringoma, the available clinical files and clinical data submitted alongside the samples at the time of the skin biopsies were analysed. The clinical data comprised: age at the time of examination, gender, clinical description of the lesions (semiology, site, whether
Results
For this 39-year period, we identified 254 samples corresponding to syringomas. For three of these samples, clinical data were absent or inconsistent and these cases were thus excluded. Seven patients underwent two biopsies for the same lesion and they were consequently counted only once. The total number of patients is thus 244. The number of cases per year ranged from 1 to 15: syringomas account for a mean 0.1% of samples each year (range: 0.02% to 0.25%, depending o the year).
Discussion
The specific value of this study is the large number of cases examined, with large patient populations being somewhat rare in this field: 29 cases in Italy in 1998 [12], 61 in Korea in 2007 [13], 27 in Spain in 2001 [14] and 34 in Iran in 2013 [15]. To our knowledge, this is the largest such worldwide study, and the only extant French study.
Our study is based on the analysis of rigorously performed examinations, reports and histopathology slides, which might have resulted in selection bias
Conclusion
To date, our study constitutes the largest worldwide series of syringomas. We confirm that the vulva constitutes a preferential site, and vulvar pruritus results. We also noted rare forms such as familial syringoma, and association with pregnancy and with metastatic melanoma. Brown colouring of lesions and pruritus are both common, and clinicians should be aware of this.
Disclosure of interest
The authors declare that they have no competing interest.
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