Comparison of Incidence, Predictors, and Outcomes of Early Infective Endocarditis after Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in the United States
Section snippets
Methods
We used the 2013 to 2014 Nationwide Readmissions Databases (NRD) for this study. The NRD is a publicly available, all-payer database developed by the Agency for Healthcare Research and Quality (AHRQ) for the Healthcare Cost and Utilization Project (HCUP). The NRD is compiled from the HCUP State Inpatient Databases that contains data from all community hospitals except rehabilitation and long-term acute care facilities. The NRD represents approximately 50% of the total US resident population and
Results
Baseline characteristics of patients who underwent TAVI or SAVR before and after propensity matching are shown in Table 1. Propensity matching yielded a cohort of 6,942 TAVI and 6,942 SAVR patients (equivalent to a weighted national estimate of 15,138 and 15,030 patients in each group, respectively) who were well balanced on demographics, co-morbidities, and hospital characteristics (standardized difference <10% for all) (Supplementary Figure 1).
In the unmatched cohort, median (IQR) follow-up
Discussion
PVE, although uncommon, is a serious complication associated with significant morbidity and mortality.14 To our knowledge, ours is the largest study to date describing the incidence, predictors, and outcomes of early IE in patients undergoing TAVI and the first large-scale study in the United States. We found that the incidence rate of early IE after TAVI was 1.7% per person-year, and that IE occurred on average 2 months following TAVI. The IE incidence rates and median time to IE were similar
Disclosures
The authors have no conflicts of interest to disclose.
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