Coronary artery diseaseComparison of Frail Patients Versus Nonfrail Patients ≥65 Years of Age Undergoing Percutaneous Coronary Intervention
Section snippets
Methods
Patients ≥65 years of age undergoing PCI at the Mayo Clinic in Rochester, Minnesota and Franciscan Skemp Hospital in LaCrosse, Wisconsin from October 2005 to September 2008 and who survived to hospital discharge were prospectively enrolled in a study assessing frailty and health status. A cross-sectional study design was used to administer standardized health status questionnaires and to perform functional assessments of frailty and abstraction of clinical co-morbidities from medical records.
Results
We screened 1,885 patients of whom 629 (33.4%) consented to participate. Slightly more men (69% vs 63%) and younger patients (74.3 ± 6.4 vs 75.8 ± 6.9 years) consented compared to nonconsenting patients. Mean age of participants was 74.8 ± 6.4 years. Of participants, 117 (18.6%) were frail, 298 (47.4%) had intermediate frailty, and 130 (20.6%) were not frail. Frailty status could not be classified in 84 patients (13.3%) because of incomplete or incorrectly completed forms. The most common
Discussion
In adults ≥65 years of age undergoing PCI, nearly 1/5 were frail as defined by the Fried criteria, and approximately 1/2 had an intermediate frailty phenotype. Features of frailty are associated with a greater co-morbid burden and greater angiographic disease severity. Frailty and intermediate frailty are independently associated with lower health-related quality of life and disease-specific quality of life. Lower quality-of-life scores for domains of physical limitation and disease-specific
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This study was supported by a grant from the Mayo Clinic, Rochester, Minnesota. Dr. Gharacholou is a participant in the clinical research loan repayment program funded by Grant 1L30 AG034828-01 from the National Institutes of Health, Bethesda, Maryland.