Brief reportInitial low-density lipoprotein response to statin therapy predicts subsequent low-density lipoprotein response to the addition of ezetimibe
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Does variation in serum LDL-cholesterol response to dietary fatty acids help explain the controversy over fat quality and cardiovascular disease risk?
2021, AtherosclerosisCitation Excerpt :Evidence from metabolic studies for the existence of such metabotypes, who are respectively less and more sensitive to dietary cholesterol, may underlie the phenomenon of hypo and hyper-responsiveness of serum LDL-C to dietary cholesterol, which may, in part, be an inherited trait [46]. The relatively greater efficacy of LDL-lowering drugs that either inhibit cholesterol synthesis or block absorption in the gut (e.g. statins and ezetimibe) in synthesisers or absorbers of cholesterol, respectively, provides further evidence for the existence of these discrete metabotypes [47,48]. The additive and even synergistic effects of dietary SFA and dietary cholesterol on serum LDL-C, reflect the fact that these dietary lipids share common determinants of cholesterol homeostasis.
Combined treatment: Regimens, indications and safety profile
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2012, Revista Espanola de Cardiologia SuplementosEffect of plant stanol tablets on low-density lipoprotein cholesterol lowering in patients on statin drugs
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2005, FMC Formacion Medica Continuada en Atencion PrimariaMolecular mechanisms of cholesterol absorption and transport in the intestine
2005, Seminars in Cell and Developmental Biology