Selections from the 26th Annual Meeting of the Society for Maternal-Fetal Medicine, January 30-February 4th, 2006, Miami, FloridaTocolysis in women with preterm labor between 32 0/7 and 34 6/7 weeks of gestation: A randomized controlled pilot study
Section snippets
Material and methods
This trial was performed at the University Hospital, Cincinnati, Ohio between August 2002 and July 2005. Pregnant women with singleton gestation, who were in preterm labor between gestational age of 32 0/7 and 34 6/7 weeks with intact amniotic membranes, a diagnosis of preterm labor and a cervical dilation of ≤4 cm were considered for the study. Preterm labor (PTL) was defined as progressive cervical dilation or effacement associated with regular uterine contractions (≥6/hr). At our
Results
A total of 54 women were enrolled; 30 were randomized to the control group (no tocolysis) and 24 were randomized to the treatment group (IV and oral tocolysis). There were 2 (7%) women in the no tocolysis group and 4 (17%) women in the tocolysis group who were maternal transfers from other institutions. Table I reports the baseline characteristics for the women at randomization. There were no statistically significant differences with regard to maternal demographics, mean cervical dilation and
Principal Findings of the Study
In this prospective, randomized clinical trial we evaluated the efficacy of aggressive tocolysis with IV MgSO4 followed by maintenance oral nifedipine in women determined to be in preterm labor between 32 0/7 and 34 6/7 weeks gestational age. Our results indicate that aggressive tocolysis does not improve neonatal outcome as measured by the total length of neonatal hospital stay. In addition, we found that neonatal morbidity is minimal at this gestational age following administration of
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Cited by (22)
Tocolysis for preterm labor without premature preterm rupture of membranes
2016, Journal de Gynecologie Obstetrique et Biologie de la ReproductionAntenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: A systematic review with metaanalysis
2015, American Journal of Obstetrics and GynecologyDoes magnesium sulfate delay the active phase of labor in women with premature rupture of membranes? A randomized controlled trial
2014, Taiwanese Journal of Obstetrics and GynecologyCitation Excerpt :Preterm labor refers to progressive cervical dilatation or effacement associated with regular uterine contractions (≤6/hour)[1].
Transdermal nitroglycerin for the treatment of preterm labor: A systematic review and metaanalysis
2013, American Journal of Obstetrics and GynecologyIndications for delivery and short-term neonatal outcomes in late preterm as compared with term births
2009, American Journal of Obstetrics and GynecologyCitation Excerpt :The question arises as to whether women presenting late preterm should be managed expectantly at 34, 35, or 36 weeks, weighing the possible benefit of prolonging a late preterm pregnancy against risks such as chorioamnionitis, eclampsia, abruptio placentae, periventricular leukomalacia, pulmonary edema, and fetal demise. The research addressing expectant management of late preterm birth is scant, and studies that have been done failed to demonstrate a benefit from expectant management of PPROM9 or tocolysis10 in late preterm labor. In fact, the ACOG recommendation for PPROM after 33 completed weeks is delivery.11
Survey of the Spanish Society of Obstetrics and Gynecology. Treatment of threatened preterm labor in Spanish hospitals
2008, Progresos en Obstetricia y Ginecologia
Presented at the 26th Annual Meeting of the Society for Maternal Fetal Medicine, Miami, FL, January 30-February 4, 2006.
Reprints not available from the authors.