Original articleAnalysis of Choroidal Thickness in Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography
Section snippets
Methods
A retrospective review was performed on 57 eyes of 47 patients with the clinical diagnosis of either wet or dry AMD seen between November 2009 and January 2010 at the New England Eye Center, Tufts Medical Center, Boston, Massachusetts. All patients included in the study underwent a comprehensive ophthalmologic examination with fundus biomicroscopy, color fundus photography, best-corrected Snellen visual acuity, fluorescein angiography, and OCT. OCT imaging was performed using Cirrus-HD OCT
Results
The study group included 23 males (40%) and 34 females (60%). Forty eyes (70%) had the diagnosis of wet AMD with a mean age of 78.6 years (standard deviation [SD], 7.0 years). Seventeen eyes (30%) had dry AMD with a mean age of 78.2 years (SD, 7.9 years). AMD is defined as a chronic, progressive degenerative disorder of the macula that affects older individuals and features central visual loss as a result of drusen deposition, geographic atrophy, serous detachment of the retinal pigment
Discussion
The choroid is a highly vascular structure that varies in thickness with intraocular and perfusion pressure and is subject to regulation by various vasoactive factors, including nitric oxide, endothelins, and autonomic innervation.18, 19, 20, 21, 22, 23 The choroid provides nutrients to the photoreceptors and removes waste products from the retinal pigment epithelium. The macula is the region of highest metabolic demand in the retina, and this has been postulated to be the reason for the
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