Major articleSurgical site infections: Causative pathogens and associated outcomes
Section snippets
Data source
We obtained the data for this study from clinical information collected in the Cardinal Health Outcomes Research Database (Cardinal Health Clinical Research Services, Marlborough, MA). This database has been used for research since the late 1980s, and the system has been fully described elsewhere.9, 10, 11 Briefly, it captures clinical information from patients admitted to participating acute care hospitals. In addition to clinical findings, the database contains chemistry and hematology
Patient population
In the population analyzed, 8302 patients met the selection criteria. The median age for the study population was 58 (interquartile range, 46-71) years, and 45.6% were male (see Table 1). Among the eligible patients, 47.3% had a previous admission at the same hospital within the prior 30 days, 4.6% were transferred from another acute care hospital, and 3.3% came from a skilled nursing facility. Three quarters of patients had at least 1 important physiologic derangement. The most frequently
Discussion
The results of this study provide an overview of the current epidemiology, microbiology, clinical outcomes, and economic costs of SSI in a large cohort of northeastern US hospitals. These 8302 patients in our study were demographically similar to those described in other studies of SSI.14
The only pathogen showing a significant change in isolation rate during the study period was MRSA, which rose from 16.1% to 20.6% among all those with culture-confirmed SSIs. These findings are compatible with
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Conflicts of interest: Dr. Weigelt is an advisory board member, on the speaker's bureau, received research support from OMJUS; Dr. Lipsky is an advisory board member and has received research support from OMJUS; Dr. Kim is a current employee of OMJUS; Ms. Derby and Drs. Tabak and Gupta are currently employees of Cardinal Health, Inc. Dr. Lipsky is an employee of the US Government. This paper does not represent the views of the US Government.