The syntax of immune-neuroendocrine communication

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Abstract

There is now overwhelming evidence that cytokines, peptide hormones and neurotransmitters, as well as their receptors, are endogenous to the brain, endocrine and immune systems. Here, Edwin Blalock discusses how these shared ligands and receptors are used as a common chemical language for communication within and between the immune and neuroendocrine systems. Such communication suggests an immunoregulatory role for the brain and a sensory function for the immune system. A clearer understanding of this circuitry is dramatically altering our understanding of physiology and may profoundly affect the treatment of human disease.

References (57)

  • A. Stephanou et al.

    Brain Behav. Immun.

    (1990)
  • D.J.J. Carr et al.

    J. Neuroimmunol.

    (1990)
  • R. Przewlocki et al.

    Neuroscience

    (1992)
  • H.L. Fehm et al.

    Life Sci.

    (1988)
  • L.C. Payne et al.

    Biochem. Biophys. Res. Commun.

    (1994)
  • L.R. Smith et al.

    J. Neuroimmunol.

    (1989)
  • J.E. Blalock

    J. Immunol.

    (1984)
  • N.K. Jerne

    Science

    (1985)
  • J.E. Blalock et al.
  • E.M. Smith et al.
  • J.E. Blalock

    Immunologist

    (1994)
  • E.M. Smith et al.
  • F.S. Galin et al.

    Prog. Neuroendocrinimmunol.

    (1990)
  • A. Lytras et al.

    Endocrinology

    (1993)
  • C.C. Maier et al.

    Cell. Mol. Neurobiol.

    (1992)
  • J.E. Blalock

    Chem. Immunol.

    (1992)
  • D.A. Weigent et al.

    Endocrinology

    (1991)
  • Prystowsky, M.B. and Clevenger C.V. ImmunoMethods (in...
  • T.E. Kruger et al.

    J. Immunol.

    (1989)
  • E.M. Smith et al.

    Science

    (1982)
  • J.E. Bayle et al.

    Prog. Neuroendocrinimmunol.

    (1991)
  • A.J. Dunn et al.

    Science

    (1987)
  • N.J. Olsen et al.

    Endocrinology

    (1992)
  • D.A. Weigent et al.

    Neuroimmunomodulation

    (1994)
  • J.E. Blalock

    Physiol. Rev.

    (1989)
  • A. Kavelaars et al.

    J. Immunol.

    (1989)
  • D.J.J. Carr

    Chem. Immunol.

    (1992)
  • E.M. Smith et al.

    New Engl. J. Med.

    (1987)
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    J. Edwin Blalock is at the Dept of Physiology and Biophysics, and the Center for Neuroimmunology, University of Alabama at Birmingham, 1918 University Blvd, Birmingham, AL 35294-0005, USA.

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