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Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates

Published online by Cambridge University Press:  15 April 2020

A. Di Florio ,
N. Craddock  and
M. van den Bree
A. Di Florio*
Affiliation:
Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff CF24 4HQ, United Kingdom
N. Craddock
Affiliation:
Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff CF24 4HQ, United Kingdom
M. van den Bree
Affiliation:
Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff CF24 4HQ, United Kingdom
*
*Corresponding author. Tel.: +44 2920 744 826. E-mail address: DiFlorioA@cf.ac.uk (A. Di Florio).
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Abstract

Aims:

To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity.

Methods:

Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias.

Results:

In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men.

Conclusion:

AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.

Keywords

Alcohol use disordersBipolar disorderComorbidityCo-occurrence
Type
Review
Information
European Psychiatry , Volume 29 , Issue 3 , March 2014 , pp. 117 - 124
Copyright
Copyright © European Psychiatric Association 2014

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