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Sexual dysfunction in patients with schizophrenia on antipsychotic medication

Published online by Cambridge University Press:  16 April 2020

Alp Üçok ,
Cem İncesu ,
Tamer Aker  and
Şahap Erkoç
Alp Üçok*
Affiliation:
Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Millet Street, Capa 34390, Istanbul, Turkey
Cem İncesu
Affiliation:
Acıbadem Hospital, Department of Psychiatry, Istanbul, Turkey
Tamer Aker
Affiliation:
Kocaeli University, Kocaeli Medical Faculty, Izmit, Turkey
Şahap Erkoç
Affiliation:
Bakırköy State Hospital of Mental Disorders, Istanbul, Turkey
*
*Corresponding author. Tel.: +90 212 4142000; fax: +90 212 5310309. E-mail address: alpucok@superonline.com (A. Ü çok).
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Abstract

Objective

The objective of this study was to determine the prevalence of sexual dysfunction in patients with schizophrenia under antipsychotic therapy and to investigate the effect of various parameters on sexual dysfunction.

Method

A total of 827 stabilized outpatients who met DSM-IV criteria for schizophrenia, were recruited in the study. Arizona Sexual Experience Scale (ASEX) and the subscale on sexual function of the UKU Side Effects Rating Scale were applied at a single interview.

Results

In total, 52.6% of the patients had sexual dysfunction, 54.2% reported a low sexual desire and 41.7% reported problems in having an orgasm. Erectile dysfunction and ejaculation problems were seen in 48.1% and 64.2% of the men, respectively; amenorrhea was seen in 24.9% of the women. ASEX score and severity of disease were found to be correlated (p = 0.02). Higher ASEX scores were observed in patients who smoked (p = 0.01). Men receiving atypical monotherapy had lower ASEX scores than those receiving a combination of atypical and conventional antipsychotics (p = 0.017). Patients on combination therapy had more ejaculation problems than the atypical group (p = 0.001). Low sexual desire was more prevalent among women using conventional drugs than those on atypical drugs (p = 0.004). In linear regression analyses, ASEX was affected significantly and independently by the severity of the disease only in men (p = 0.005).

Conclusion

Our results show that sexual dysfunction is widespread among patients with schizophrenia on antipsychotic medications.

Keywords

SchizophreniaSexual dysfunctionTypical antipsychoticsAtypical antipsychoticsASEX
Type
Original article
Information
European Psychiatry , Volume 22 , Issue 5 , July 2007 , pp. 328 - 333
Copyright
Copyright © Elsevier Masson SAS 2007

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