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Inicio Vacunas (English Edition) Adjuvanted AH1N1 influenza vaccine precipitating the appearance of narcolepsy
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Vol. 22. Issue 2.
Pages 119-124 (May - August 2021)
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Vol. 22. Issue 2.
Pages 119-124 (May - August 2021)
Review article
Adjuvanted AH1N1 influenza vaccine precipitating the appearance of narcolepsy
Vacuna frente a influenza H1N1 con adyuvante AS03 y su efecto desencadenante de narcolepsia
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A. Boquete Castro
Corresponding author
boket_odo@hotmail.com

Corresponding author.
, J.M. Cortés Mejía
Máster en Medicina Dental del Sueño, Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain
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Table 1. Synthesis of the main data provided by the studies included in this systematic review.
Abstract

The vaccination against influenza A-H1N1 applied during the pandemic of 2009 demonstrated a positive association with the appearance of narcolepsy and/or concomitant cataplexy. Narcolepsy is a hypersomnia that affects greatly quality life of people that suffer from it. The present manuscript is an updated literature review regarding scientific evidence in this field. Reviewed scientific literature shows a positive relation between A-H1N1 vaccine and appearance of narcolepsy cases, however, etiopathogenic aspects are still unknown, so more studies are necessary, especially in the current moment, were some authors estipulate that a vaccine against SARS COVID-19 could cause similar effects that is crucial to minimize them.

Keywords:
Narcolepsy
Influenza A
Pandemic
Cataplexy
Resumen

La vacunación frente a la epidemia de influenza A-H1N1 que se aplicó durante la pandemia de 2009 ha demostrado tener una asociación positiva con la aparición de narcolepsia y/o cataplejía concomitante. La narcolepsia es una hipersomnia que afecta de manera importante la calidad de vida de quien la padece. El presente trabajo es una revisión bibliográfica actualizada acerca de la evidencia disponible en este sentido. La literatura revisada demuestra una relación positiva entre la vacuna frente a la influenza A-H1N1 y la aparición de narcolepsia, si bien el mecanismo etiopatogénico es aún desconocido, por lo que se hacen necesarios más estudios, especialmente en el momento actual, en que algunos autores apuntan a que la vacuna frente a SARS COVID-19 podría causar efectos similares que es necesario minimizar.

Palabras clave:
Narcolepsia
Influenza A
Pandemia
Cataplejía

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