Toxicidade induzida pela terapêutica intermitente com Rifampicina: Análise de um caso clínico

Azevedo, Pilar; Meneses, F.; Monteiro, J.; Rosal Gonçalves, J.; Monteiro, F.; Valença Rodrigues, J.; Fraga Brum, G.; Couto, A.; Freitas e Costa, M.

doi:10.1016/S0873-2159(15)31092-8

Pulmonology

ISSN: 2531-0437

Pulmonology (previously Revista Portuguesa de Pneumologia) is the official journal of the Portuguese Society of Pulmonology (Sociedade Portuguesa de Pneumologia/SPP). The journal publishes 6 issues per year, mainly about respiratory system diseases in adults and clinical research. This work can range from peer-reviewed original articles to review articles, editorials, and opinion articles. The journal is printed in English, and is freely available in its web page as well as in Medline and other databases.

Special Issue 2023. Volume 29, Issue S4.

Indexed in:

Science Citation Index Expanded, Journal of Citation Reports; Index Medicus/MEDLINE; Scopus; EMBASE/Excerpta Medica

Descrevese o quadro clíoico de uma doente que desenvolveu uma reacção sistémica de hipersensibilidade grave a Rifampicina, objectivada por síndrome pseudo-gripal, anemia hemolítica, insuficiência renal aguda, choque e epidermólise bolhosa necrosante. Além da evolução clínica, salientase a dificuldade na formulação do diagnóstico e o apoio dado pelo laboratório na sua confirmação.

Palavras-chave:

Rifampicina

Efeitos ad versos

Imunologia

Toxicidade

SUMMARY

We repport the case of a patient who developed a severe drug-induced hypersensitivity sistemic reaction to Rifampicin, that included a flulike syndrome, severe hemolytic anaemia, renal failure, shock and toxic epidermal necrolysis.

Besides the clinical evolution we consider the difficulties in clinical diagnosis and the role of the in vitro laboratory assays.

Key-words:

Rífampicin;Adverse effects

Immunology

Toxicity

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BIBLIOCRAFIA

[1.]

O.J. Girling.

Adverse effects of antituberculosis drugs.

Drugs, 23 (1982), pp. 56-74

Medline

[2.]

O.J. Girling, L. Hitzek.

Adverse reactions to Rifampicine.

Bulletin of the World Health Organization, 57 (1979), pp. 45-49

Medline

[3.]

Larbaou.

Chimiothérapic antituberculeuse: Encyclopedic Médico-Chirurgicale (Paris, France).

Poumon, 6019A (1986), pp. 20

[4.]

P.P. Vanarsdel.

Drug allergy.

Immunology and Allergy Clinics of North America (Philadelphia), 1 (1991),

[5.]

WINBERG S., LIEBERMAN P. Anaphilaxis in Systemic reactions. Immunology and Allergy Clinics of North America (Philadelphia), Saunders ed. 15 (3): 447-477.

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