Terapêutica com metotrexato na sarcoidose

Pascoal, I.; Winck, J.C.; Carvalho, A.; Rodrigues, F.F.

doi:10.1016/S0873-2159(15)31215-0

Pulmonology

ISSN: 2531-0437

Pulmonology (previously Revista Portuguesa de Pneumologia) is the official journal of the Portuguese Society of Pulmonology (Sociedade Portuguesa de Pneumologia/SPP). The journal publishes 6 issues per year, mainly about respiratory system diseases in adults and clinical research. This work can range from peer-reviewed original articles to review articles, editorials, and opinion articles. The journal is printed in English, and is freely available in its web page as well as in Medline and other databases.

Special Issue 2023. Volume 29, Issue S4.

Indexed in:

Science Citation Index Expanded, Journal of Citation Reports; Index Medicus/MEDLINE; Scopus; EMBASE/Excerpta Medica

Os autores descrevem um caso clínico de um homem de 33 anos com sarcoidose estádio II, em que, durante corticoterapia de longo curso surge osteonecrose da cabeça do fémur direito. Devido a este efeito secundário, foi iniciada terapêutica com metotrexato, com melhoria clínica e funcional. São também discutidas as indicações da corticoterapia e analisada a experiência com a utilização do metotrexato na sarcoidose.

Palavras-chave:

Sarcoidose

osteonecrose

corticoterapia

metotrexato

ABSTRACT

The authors describe a case of a 33 year old male with stage II sarcoidosis, developping osteonecrosis of the right femoral head while on long term corticosteroids. Due to this severe side-effect, methotrexate was introduced, with significant clinical/functional improvement The role of corticosteroids in this setting are analysed as well as the experience with methotrexate in sarcoidosis.

Key-Words:

Sarcoidosis

osteonecrosis

corticosteroids

methotrexate

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