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Vol. 18. Núm. 3.
Páginas 203-220 (Septiembre 2011)
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Vol. 18. Núm. 3.
Páginas 203-220 (Septiembre 2011)
DOI: 10.1016/S0121-8123(11)70054-8
Acceso a texto completo
Linfocitos T reguladores: Subpoblaciones, mecanismo de acción e importancia en el control de la autoinmunidad
T regulatory lymphocytes: subpopulations, mechanism of action and importance in the control of autoimmunity
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...
Heber Siachoque1, Natalia Satisteban2, Antonio Iglesias-Gamarra3
1 MSc, Coordinador de la unidad de Inmunología, Facultad de Medicina, Universidad del Rosario
2 MD, Estudiante de toxicología, Facultad de Medicina, Universidad del Rosario
3 MD. Profesor titular, Facultad de Medicina, Universidad Nacional de Colombia
Información del artículo
Resumen

La regulación inmunológica constituye tanto un mecanismo importante para el mantenimiento de la homeostasis del sistema inmune como para el establecimiento de la tolerancia hacia antígenos propios evitando el desarrollo de enfermedades autoinmunitarias. Así mismo, juega un papel relevante en el mantenimiento de la tolerancia periférica mediante el control de una pequeña población de células T circulantes denominadas células T reguladoras (Treg), las cuáles parecen haber migrado del timo durante estadios relativamente tardíos1.

El término “células T reguladoras” se refiere a células que activan o suprimen la función de otras células. Aparentemente, controlan el desarrollo de enfermedades autoinmunitarias (lupus, tiroiditis, diabetes tipo I y enfermedad inflamatoria intestinal entre otras) el rechazo de injertos, y pueden jugar un papel crítico en el control del asma y la alergia.

Palabras clave:
fenotipo
singénicos
FoxP3
TGF-β
anergia
autóloga
escurfina
Treg
APC
células presentadoras de antígeno
receptor de células T (TCR)
Complejo Mayor de Histocompatibilidad (CMH)
Summary

Immune regulation is both an important mechanism for maintaining immune system homeostasis and for the establishment of tolerance towards self antigens in order to prevent the development of autoimmune diseases. It also plays an important role in maintaining peripheral tolerance by controlling a small population of circulating T cells, called regulatory T cells (Treg), which seems to have migrated from the thymus during relatively late stages1.

The term “regulatory T cells” refers to cells that activate or suppress the function of other cells. Apparently, controlling the development of autoimmune diseases (For instance, lupus, thyroiditis, type I diabetes and inflammatory bowel disease among others), graft rejection and may play a critical role in asthma and allergy.

Key words:
phenotype
syngeneic
FoxP3
TGF-β
anergy
autologous
escurfina
Treg
antigen presenting cells (APC)
T cell receptor (TCR)
Mayor Histocompatibility Complex (MHC)
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Los autores declaran no presentar ningún conflicto de interés al momento de la redacción del manuscrito.

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