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Vol. 17. Núm. 4.
Páginas 212-218 (Diciembre 2010)
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Vol. 17. Núm. 4.
Páginas 212-218 (Diciembre 2010)
Acceso a texto completo
Insuficiencia de vitamina D en pacientes adultos con baja masa ósea y osteoporosis en la Fundación Santa Fe de Bogotá 2008–2009
Vitamin D insufficiency in adults patients with low bone mass and osteoporosis in the Fundación Santa Fe de Bogotá 2008-2009
Visitas
3247
Deyanira González Devia1,
Autor para correspondencia
, Claudia Zúñiga Libreros2, William Kattah Calderón3
1 Internista Endocrinóloga, Médica institucional del Hospital Universitario Fundación Santa Fe de Bogotá. Coordinadora del grupo hueso saludable de la FSFB. Profesora de Cátedra, Facultad de Medicina, Universidad de los Andes
2 Internista, Universidad del Rosario
3 Internista Endocrinólogo, Jefe de la sección de endocrinología, Departamento de Medicina Interna, Hospital Universitario Fundación Santa Fe de Bogotá, Profesor Clínico, Facultad de Medicina, Universidad de los Andes
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Resumen

La hipovitaminosis D se asocia con osteoporosis, enfermedades neuromusculares, autoinmunes y cáncer. La prevalencia oscila entre 11% y 70% en diferentes poblaciones estudiadas. Debido a que la osteoporosis es una enfermedad frecuente, determinamos la prevalencia de hipovitaminosis D asociada a desmineralización ósea en población atendida en la FSFB entre agosto de 2008 y julio de 2009; revisamos edad, género, T-Score, Z-score. Se consideró como rango normal de 25OHD entre 32 y 150ng/dl. Hallamos 460 determinaciones de 25OHD, 105 sujetos con osteodensitometría DXA, 80% mujeres. Edad promedio 66 años (DE±12,5; rango 39 a 91); para mujeres fue 67,1 años (DE±12,2; rango 39 a 91), para hombres fue 61 años (DE±10,7; rango 42 a 82). Los niveles de 25OHD promedio fueron de 31ng/ml (DE±17,6; rango 8,2 a 110); para mujeres 30,5ng/ml (DE±16,1; rango 10,6 a 96ng/ml), para hombres 33,5ng/ml (DE±23,4; rango 8,2 a 110ng/ml). El 69,5% de casos presentaron algún nivel de insuficiencia de vitamina D, 45,7% insuficiencia leve y 23,8% insuficiencia moderada; no hay casos con insuficiencia severa. No hubo diferencias significativas entre concentraciones de 25OHD entre hombres y mujeres; o edad. La osteoporosis se correlaciona con niveles de 25OHD inferiores a 28 ng/ml (P= 0,046), pero no hay correlación entre niveles bajos de 25OHD y osteopenia. La hipovitaminosis D es muy prevalente en pacientes con osteoporosis y baja masa ósea y debe evaluarse en el contexto de osteoporosis.

Palabras clave:
vitamina D
osteoporosis
baja masa ósea
osteopenia
Summary

Hypovitaminosis D is associated with osteoporosis, neuromuscular diseases, autoimmune diseases and cancer. The prevalence varies from 11–70% in different populations. Due osteoporosis is a common disease, we determined the prevalence of hypovitaminosis D associated with bone demineralization in FSFB population evaluated between August 2008 and July 2009, we reviewed age, gender, T-Score, Z-score. Values between 32–150ng/ml were considered as normal. We found 460 25OHD results, 105 subjects with mineral density for DXA method, 80% female. Mean age for women was 66 years (SD±12.5, range 39–91) for women was 67.1 years (SD±12.2, range 39–91) for men was 61 years (SD±10.7, range 42–82). Mean 25OHD levels were 31ng / ml (SD±17.6, range 8.2 to 110), for women 30.5ng / mL (SD±16.1, range 10.6 to 96ng / mL), for men 33.5ng / mL (SD±23.4, range 8.2 to 110ng / mL). 69,5% of cases were considered as vitamin D insufficiency, 45,7% mild, 23,8% moderate, and no cases of severe déficit. No significant difference between 25OHD concentrations and gender, or age were considered. Osteoporosis was correlated with 25OHD levels below 28ng/ml (P=0,046) but not between low 25OHD and subjects with osteopenia. The vitamin D deficiency is highly prevalent in patients with osteoporosis and low bone mass and should be evaluated in the context of osteoporosis.

Key words:
vitamina D
osteoporosis
osteopenia
low bone density
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