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Vol. 17. Núm. 2.
Páginas 111-122 (Junio 2010)
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Vol. 17. Núm. 2.
Páginas 111-122 (Junio 2010)
Acceso a texto completo
Asociación de lupus eritematoso sistémico y esclerosis múltiple: esclerosis lupoide. Descripción de cuatro casos
Asociation between systemic lupus erythematosus and multiple sclerosis: lupoid sclerosis
Yimy F. Medina1, José B. Martínez1, Andrés R. Fernández1, Gerardo Quintana1, José Félix Restrepo2, Federico Rondón3, Antonio Iglesias Gamarra2
1 Médico Internista, Reumatólogo. Universidad Nacional
2 Profesor titular de Medicina Interna y Reumatología. Universidad Nacional
3 Profesor asociado de Medicina Interna y Reumatología. Universidad Nacional
Información del artículo

La esclerosis múltiple (EM) y el lupus eritematoso sistémico (LES) con o sin síndrome antifosfolípido son enfermedades autoinmunes. Se ha descrito en varias ocasiones la asociación de estas enfermedades o se ha descrito el cuadro clínico de la EM con características de laboratorio de LES. Cuando afectan al sistema nervioso central pueden hacerlo en forma definida para cada enfermedad pero también pueden hacerlo en forma interpuesta o combinada de las dos enfermedades, a lo que se le ha llamado esclerosis lupoide, haciendo que en algunos casos sea difícil la diferenciación de las dos enfermedades y por lo tanto direccionar el tratamiento. Presentamos cuatro casos de esclerosis lupoide, discutimos acerca de las características clínicas y de laboratorio de esta entidad y hacemos una diferenciación de la esclerosis múltiple y de la afectación neurológica del LES, especialmente por imágenes y resultados de laboratorio.

Palabras clave:
lupus eritematoso sistémico
esclerosis múltiple
sistema nervioso central
esclerosis lupoide.

Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE) with/without antiphospholipid syndrome are autoinmune illnesses. It has been described in many occasions the association of these two illnesses and the clinical picture of MS with characteristics of laboratory of SLE. When they affect to the central nervous system they can make it in a defined form for each illness or they can also make it in interposed or combined form of the two illnesses what has been called lupoid sclerosis; making that in some cases difficult the differentiation of the two illnesses and therefore to address the treatment. We present four cases of lupoid sclerosis, discuss the clinical and laboratory characteristics of this entity and we make a differentiation of the multiple sclerosis with the neurological affectation of SLE especially for images and laboratory results.

Key words:
systemic lupus erithematosus
sclerosis multiple
central nervous system
lupoid sclerosis.
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