Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Geographical distribution of mortality by Parkinson's disease and its associ...
Journal Information
Vol. 147. Issue 11.
Pages 481-487 (December 2016)
Share
Share
Download PDF
More article options
Visits
5
Vol. 147. Issue 11.
Pages 481-487 (December 2016)
Original article
Geographical distribution of mortality by Parkinson's disease and its association with air lead levels in Spain
Patrón geográfico de la mortalidad por enfermedad de Parkinson en España y su asociación con los niveles de plomo en el aire
Visits
5
Ana Santurtúna,
Corresponding author
ana.santurtun@unican.es

Corresponding author.
, Manuel Delgado-Alvaradob, Alejandro Villarc, Javier Rianchod
a Unidad de Medicina Legal, Departamento de Fisiología y Farmacología, Universidad de Cantabria, Santander, Spain
b Área de Investigación de Neurociencias, Instituto de Investigación Sanitaria Biodonostia, San Sebastián, Guipúzcoa, Spain
c TICNOR S.L., Santander, Spain
d Servicio de Neurología, Hospital Universitario Marqués de Valdecilla-IDIVAL (CIBERNED), Santander, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Tables (2)
Table 1. Analysis by sex and age group of death rates per million in each county.
Table 2. Levels of lead, average death rate of Parkinson's disease in over 64 years of age by sex and its standard deviation.
Show moreShow less
Abstract
Background and objective

Parkinson's disease (PD) is the second most common neurodegenerative disease, and the aetiology of its sporadic form is unknown. The present study analyzes the temporal and spatial variations of mortality by PD in Spain over a period of 14 years and its relationship with lead concentration levels in the atmosphere.

Method

An ecological study was performed, in which deaths by PD and age group in 50 Spanish provinces between 2000 and 2013 were analyzed. The annual trend of PD mortality was assessed using the non-parametric Spearman's Rho test. Finally, the relationship between lead concentration levels in the air and mortality by PD was evaluated.

Results

Between 2000 and 2013, 36,180 patients with PD died in Spain. There is an increasing trend in mortality through PD over the study period (p<.0001). La Rioja, Asturias, Basque Country and the Lower Ebro valley were the regions with the highest values of PD mortality. Those regions with the highest lead concentrations also showed higher mortality by this disease in people over 64 (p=0.02).

Conclusions

Over our period of study, there has been an increase in mortality through PD in Spain, with the northernmost half of the country registering the highest values. Mortality in men was higher than mortality in women. Moreover, a direct correlation was found between lead levels in the air and mortality through PD.

Keywords:
Parkinson's disease
Lead
Particulate matter
Resumen
Fundamentos y objetivo

La enfermedad de Parkinson (EP) es la segunda dolencia neurodegenerativa más frecuente y su etiología en las formas esporádicas es desconocida. El presente estudio analiza las variaciones temporales y geográficas en la mortalidad por EP en España a lo largo de los últimos 14 años, y la relación entre la mortalidad por EP y los niveles de plomo en las partículas del aire.

Método

Se ha realizado un estudio ecológico en el que se han analizado las muertes por EP por grupos de edad, en las 50 provincias españolas entre 2000 y 2013. La tendencia anual de la mortalidad por EP se calculó mediante el test no paramétrico Rho de Spearman. Finalmente, se analizó la asociación entre los niveles de plomo y la mortalidad por EP.

Resultados

Entre 2000 y 2013 fallecieron en España 36.180 pacientes con EP. Existe una tendencia ascendente en la mortalidad por EP a lo largo del período estudiado (p<0,0001). La Rioja, Asturias, el País Vasco y el valle del Bajo Ebro acumulan la mayor incidencia de mortalidad por EP. En las regiones con más plomo, la tasa de mortalidad por EP en mayores de 64 años es superior (p=0,02).

Conclusiones

En la última década la mortalidad por EP ha aumentado en España, siendo la mitad norte del país la que registra una mayor incidencia. La mortalidad en varones fue mayor que en mujeres. Además, se encuentra una asociación entre los niveles de plomo en el aire y la tasa de mortalidad por EP.

Palabras clave:
Enfermedad de Parkinson
Plomo
Material particulado

Article

These are the options to access the full texts of the publication Medicina Clínica (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Clínica (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos