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Vol. 14. Núm. 4.
Páginas 264-276 (Diciembre 2010)
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Vol. 14. Núm. 4.
Páginas 264-276 (Diciembre 2010)
Open Access
Fiebre manchada de las montañas rocosas: ni tan manchada ni tan montañosa como pensábamos
Rocky Mountain Spotted Fever: not as spotted or as mountainous as thought
Visitas
4144
James Samir Díaz1, Juan Carlos Cataño2,
Autor para correspondencia
kataju@hotmail.com

Correspondencia: Calle 8 sur N° 43B-112, Medellín, Colombia. Tel.:éfono: (57-4) 448-1001.
1 Médico internista, Universidad de Antioquia, Medellín, Colombia
2 Médico internista infectólogo, Universidad de Antioquia, Medellín, Antioquia
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Información del artículo
Resumen

La iebre manchada de las Montañas Rocosas es una infección producida por Rickettsia rickettsii, un cocobacilo polimorfo perteneciente a la familia Rickettsiaceae. A pesar de que ha pasado más de un siglo desde que fue descrita, continúa siendo una de las zoonosis más importantes en todo el mundo. Aunque los casos se presentan de manera focal y esporádica, en los últimos años se ha notado un incremento de su incidencia en los Estados Unidos y parece estar resurgiendo en varios países de Suramérica. En Colombia, poco se sabía de la enfermedad desde 1937, cuando fue descrita por primera vez, pero, en los últimos años se han presentado nuevos casos con alta tasa de mortalidad. Dado que los hallazgos clínicos y de laboratorio son inespecíicos, la iebre manchada de las Montañas Rocosas debe incluirse en el diagnóstico diferencial de los síndromes febriles de causa no clara.

A continuación se presenta una revisión de la literatura, señalando los aspectos más importantes del resurgimiento de la enfermedad en Colombia y se resaltan su etiopatogenia, manifestaciones clínicas, diagnóstico y tratamiento, con el objeto de mejorar el conocimiento local de esta infección, probablemente subdiagnosticada, que puede curarse fácilmente con unas cuantas dosis de antibióticos por vía oral.

Palabras clave:
rickettsiosis
iebre manchada de las Montañas Rocosas
iebres hemorrágicas
brote
epidemia
epidemiología
Colombia
Abstract

Rocky Mountain Spotted Fever (RMSF) is an infection caused by Rickettsia rickettsii, a pleomorphic cocobacillae which belongs to the Rickettsiaceae family. Although it has been more than a century since its irst description, this disease is still one of the most important zoonosis in the world. Usually cases occur in focal and sporadic form, but an unusual increase in the frequency of cases during the last few years has drawn the attention of surveillance systems in United States and some South American countries. Little was known about the disease in Colombia when it was irst described in 1937, but in recent years new cases have been reported showing high mortality rates. Since clinical and laboratory indings have not been speciic, the RMSF must be included in the differential diagnosis of febrile syndromes of unknown origin. A literature review follows herein, pointing out the most important features of the cases diagnosed in Colombia and highlighting their pathogenesis, clinical manifestations, diagnosis, and treatment, and attempting to improve local knowledge of this infection. The disease is probably under-diagnosed and could be treated with a few doses of PO antibiotics.

Key words:
Rickettsiosis
Rocky mountain spotted fever
Haemorrhagic fever
outbreak
epidemic
epidemiology
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Bibliografías
[1.]
H. Ricketts.
The study of “Rocky Mountain spotted fever” (tick fever?) by means of animal inoculations. A preliminary communication.
JAMA, 47 (1906), pp. 33-36
[2.]
J.S. Dumler, D.H. Walker.
Rocky Mountain spotted fever changing ecology and persisting virulence.
N Engl J Med, 353 (2005), pp. 551-553
[3.]
C.D. Paddock, S. Fernández, G.A. Echenique, J.W. Sumner, W.K. Reeves, S.R. Zaki, et al.
Rocky Mountain spotted fever in Argentina.
Am J Trop Med Hyg, 78 (2008), pp. 687-692
[4.]
M.B. Labruna.
Ecology of rickettsia in South America.
Ann N Y Acad Sci, 1166 (2009), pp. 156-166
[5.]
A. EstradaPeña, A.A. Guglielmone, A.J. Mangold.
The distribution and ecological ‘preferences’ of the tick Amblyomma cajennense (Acari: Ixodidae), an ectoparasite of humans and other mammals in the Americas.
Ann Trop Med Parasitol, 98 (2004), pp. 283-292
[6.]
E. Guedes, R.C. Leite, M.C. Prata, R.C. Pacheco, D.H. Walker, M.B. Labruna.
Detection of Rickettsia rickettsii in the tick Amblyomma ca jennense in a new Brazilian spotted feverendemic area in the state of Minas Gerais.
Mem Inst Oswaldo Cruz, 100 (2005), pp. 841-845
[7.]
A. Pinter, M.B. Labruna.
Isolation of Rickettsia rickettsii and Ric kettsia bellii in cell culture from the tick Amblyomma aureolatum in Brazil.
Ann N Y Acad Sci, 1078 (2006), pp. 523-529
[8.]
J. MoraesFilho, A. Pinter, R.C. Pacheco, T.B. Gutmann, S.O. Barbosa, M.A. Gonzales, et al.
New epidemiological data on Brazilian spotted fever in an endemic area of the state of Sao Paulo Brazil.
Vector Borne Zoonotic Dis, 9 (2009), pp. 73-78
[9.]
J.E. McDade, V.F. Newhouse.
Natural history of Rickettsia rickettsii.
Annu Rev Microbiol, 40 (1986), pp. 287-309
[10.]
W. Burgdorfer, L.P. Brinton.
Mechanisms of transovarial infection of spotted fever Rickettsiae in ticks.
Ann N Y Acad Sci, 266 (1975), pp. 61-72
[11.]
M.L. Niebylski, M.G. Peacock, T.G. Schwan.
Lethal effect of Rickettsia rickettsii on its tick vector (Dermacentor andersoni).
Appl Environ Microbiol, 65 (1999), pp. 773-778
[12.]
D.H. Walker, C.D. Paddock, J.S. Dumler.
Emerging and reemerging ticktransmitted rickettsial and ehrlichial infections.
Med Clin North Am, 92 (2008), pp. 1345-1361
[13.]
J.R. Carmichael, P.A. Fuerst.
A rickettsial mixed infection in a Dermacentor variabilis tick from Ohio.
Ann NY Acad Sci, 1078 (2006), pp. 334-337
[14.]
P. Acha, B. Szyfres.
Zoonoses and communicable diseases common to man and animals.
Pan American Health Organization, (1989),
[15.]
F.M. Bozeman, A. Shiral, J.W. Humphries, H.S. Fuller.
Ecology of Rocky Mountain spotted fever II. Natural infection of wild mammals and birds in Virginia and Maryland.
Am J Trop Med Hyg, 16 (1967), pp. 48-59
[16.]
L.A. Sangioni, M.C. Horta, M.C. Vianna, S.M. Gennari, R.M. Soares, M.A. Galvao, et al.
Rickettsial infection in animals and Brazilian spotted fever endemicity.
Emerg Infect Dis, 11 (2005), pp. 265-270
[17.]
R.C. Pacheco, M.C. Horta, J. MoraesFilho, A.C. Ataliba, A. Pinter, M.B. Labruna.
Rickettsial infection in capybaras (Hydrochoerus hydrochaeris) from Sao Paulo Brazil: serological evidence for infection by Rickettsia bellii and Rickettsia parkeri.
Biomédica, 27 (2007), pp. 364-371
[18.]
C.D. Paddock, J.W. Sumner, J.A. Comer, S.R. Zaki, C.S. Goldsmith, J. Goddard, et al.
Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States.
Clin Infect Dis, 38 (2004), pp. 805-811
[19.]
D. Raoult, C.D. Paddock.
Rickettsia parkeri infection and other spotted fevers in the United States.
N Engl J Med, 353 (2005), pp. 626-627
[20.]
C.D. Paddock.
Rickettsia parkeri as a paradigm for multiple causes of tickborne spotted fever in the western hemisphere.
Ann N Y Acad Sci, 1063 (2005), pp. 315-326
[21.]
J.M. Venzal, A. Portillo, A. EstradaPeña, O. Castro, P.A. Cabrera, J.A. Oteo.
Rickettsia parkeri in Amblyomma triste from Uruguay.
Emerg Infect Dis, 10 (2004), pp. 1493-1495
[22.]
I. Silveira, R.C. Pacheco, M.P. Szabo, H.G. Ramos, M.B. Labruna.
Rickettsia parkeri in Brazil.
Emerg Infect Dis, 13 (2007), pp. 1111-1113
[23.]
J. Piza, L. SallesGomes, H. Rocha Lima.
Le typhus exanthematique a Sao Paolo.
CR Soc Seances Soc Biol Fil, 1106 (1931), pp. 1020-1022
[24.]
E. Dias, A.V. Martins.
Spotted fever in Brazil. A summary.
Am J Trop Med Hyg, 19 (1939), pp. 103-108
[25.]
C.M. Ripoll, C.E. Remondegui, G. Ordoñez, R. Arazamendi, H. Fusaro, M.J. Hyman, et al.
Evidence of rickettsial spotted fever and ehrlichial infections in a subtropical territory of Jujuy Argentina.
Am J Trop Med Hyg, 61 (1999), pp. 3504
[26.]
I.A. ContiDiaz, I. Rubio, M. Somma, G. Perez.
Lymphatic cutaneous rickettsiosis caused by Rickettsia conorii in Uruguay.
Rev Inst Med Trop Sao Paulo, 32 (1990), pp. 313-318
[27.]
P.J. López Del, V.K. Abarca, A.T. Azocar.
Clinical and serological evidence of canine rickettsiosis in Chile.
Rev Chilena Infectol, 24 (2007), pp. 189-193
[28.]
J.E. ZavalaCastro, J.E. ZavalaVelázquez, D.H. Walker, E.E. Ruiz, H. Lavia daMolina, J.P. Olano, et al.
Fatal human infection with Rickettsia rickettsii, Yucatán, México.
Emerg Infect Dis, 12 (2006), pp. 672-674
[29.]
L.G. Fuentes.
First case of Rocky Mountain spotted fever in Costa Rica, Central America.
Rev Latinoam Microbiol, 21 (1979), pp. 167-172
[30.]
E.C. De Rodaniche.
Natural infection of the tick, Amblyomma cajennense, with Rickettsia rickettsii in Panama.
Am J Trop Med Hyg, 2 (1953), pp. 696-699
[31.]
E.C. de Rodaniche, A. Rodaniche.
Spotted fever in Panama; isolation of the etiologic agent from a fatal case.
Am J Trop Med Hyg, 30 (1950), pp. 511-517
[32.]
D. Estripeaut, M.G. Aramburu, X. SaezLlorens, H.A. Thompson, G.A. Dasch, C.D. Paddock, et al.
Rocky Mountain spotted fever, Pa Rocky Mountain spotted fever Panama.
Emerg Infect Dis, 13 (2007), pp. 1763-1765
[33.]
L.J. Da Silva.
Enfermedades transmitidas por garrapatas en humanos.Ocurrencia, distribución e impacto en salud pública, con énfasis en el estado de São Paulo.
Consulta OPS/OMS de expertos sobre rickettsiosis en las Américas Informe Final,
[34.]
D.H. Walker.
Ticktransmitted infectious diseases in the United States.
Annu Rev Public Health, 19 (1998), pp. 237-269
[35.]
L. Patiño, A. Afanador, J.H. Paul.
A spotted fever in Tobia, Colombia: Prelimirary report.
Am J Trop Med Hyg, 17 (1937), pp. 639-653
[36.]
A. Miranda, S. Flórez, S. Mattar.
Alta seroprevalencia de rickettsiosis en trabajadores del campo en el municipio de Ciénaga de Oro, Córdoba.
Inf Quinc Epidemiol Nac, 7 (2002), pp. 71-75
[37.]
M. Hidalgo, L. Orejuela, P. Fuya, P. Carrillo, J. Hernández, E. Parra, et al.
Rocky Mountain spotted fever Colombia.
Emerg Infect Dis, 13 (2007), pp. 1058-1060
[38.]
M. Hidalgo, R. Sánchez, L. Orejuela, J. Hernández, D.H. Walker, G. Valbuena.
Prevalence of antibodies against spotted fever group rickettsiae in a rural area of Colombia.
Am J Trop Med Hyg, 77 (2007), pp. 378-380
[39.]
E.R. de Lemos, F.B. Alvarenga, M.L. Cintra, M.C. Ramos, C.D. Paddock, T.L. Ferebee, et al.
Spotted fever in Brazil: a seroepidemiological study and description of clinical cases in an endemic area in the state of Sao Paulo.
Am J Trop Med Hyg, 65 (2001), pp. 329-334
[40.]
J.E. ZavalaVelázquez, J. RuizSosa, I. VadoSolis, A.N. Billings, D.H. Walker.
Serologic study of the prevalence of rickettsiosis in Yucatán: evidence for a prevalent spotted fever group rickettsiosis.
Am J Trop Med Hyg, 61 (1999), pp. 405-408
[41.]
J. Acosta, L. Urquijo, A. Díaz, M. Sepúlveda, G. Mantille, D. Heredia, et al.
Brote de rickettsiosis en Necoclí Antioquia, febreromarzo de 2006.
Inf Quinc Epidemiol Nac, 11 (2006), pp. 177-192
[42.]
M. Hidalgo, D. Lizarazo, M.V. Ovalle, E. Parra, M. Vera, A. Porras, et al.
Brote de rickettsiosis en Los Córdobas, departamento de Córdoba, febreromarzo 2007.
Inf Quinc Epidemiol Nac, 12 (2007), pp. 371-375
[43.]
W.H. Price.
The epidemiology of Rocky Mountain spotted fever II. Studies on the biological survival mechanism of Rickettsia rickettsii.
Am J Hyg, 60 (1954), pp. 292-319
[44.]
L.F. Chen, D.J. Sexton.
What's new in Rocky Mountain spotted fever?.
Infect Dis Clin North Am, 22 (2008), pp. 415-432
[45.]
P.A. CrocquetValdés, C.M. DíazMontero, H.M. Feng, H. Li, A.D. Barrett, D.H. Walker.
Immunization with a portion of rickettsial outer membrane protein A stimulates protective immunity against spotted fever rickettsiosis.
Vaccine, 20 (2001), pp. 979-988
[46.]
J.J. Martínez, S. Seveau, E. Veiga, S. Matsuyama, P. Cossart.
Ku70, a component of DNAdependent protein kinase, is a mammalian receptor for Rickettsia conorii.
Cell, 123 (2005), pp. 1013-1023
[47.]
D.H. Walker, G.A. Valbuena, J.P. Olano.
Pathogenic mechanisms of diseases caused by Rickettsia.
Ann N Y Acad Sci, 990 (2003), pp. 1-11
[48.]
J.J. Martínez, P. Cossart.
Early signaling events involved in the entry of Rickettsia conorii into mammalian cells.
J Cell Sci, 117 (2004), pp. 5097-5106
[49.]
D.H. Walker.
Targeting rickettsia.
N Engl J Med, 354 (2006), pp. 1418-1420
[50.]
D.J. Silverman, C.L. Wisseman Jr., A.D. Waddell, M. Jones.
External layers of Rickettsia prowazekii and Rickettsia rickettsii: occurrence of a slime layer.
Infect Immun, 22 (1978), pp. 233-246
[51.]
S.F. Hayes, W. Burgdorfer.
Reactivation of Rickettsia rickettsii in Dermacentor andersoni ticks: an ultrastructural analysis.
Infect Immun, 37 (1982), pp. 779-785
[52.]
R.A. Heinzen, S.S. Grieshaber, L.S. van Kirk, C.J. Devin.
Dynamics of actinbased movement by Rickettsia rickettsii in vero cells.
Infect Immun, 67 (1999), pp. 4201-4207
[53.]
R.A. Heinzen.
Rickettsial actinbased motility: behavior and involvement of cytoskeletal regulators.
Ann N Y Acad Sci, 990 (2003), pp. 535-547
[54.]
C.L. Wisseman Jr., E.A. Edlinger, A.D. Waddell, M.R. Jones.
Infection cycle of Rickettsia rickettsii in chicken embryo and L929 cells in culture.
Infect Immun, 14 (1976), pp. 1052-1064
[55.]
D.J. Silverman.
Adherence of platelets to human endothelial cells infected by Rickettsia rickettsii.
J Infect Dis, 153 (1986), pp. 694-700
[56.]
M.T. Elghetany, D.H. Walker.
Hemostatic changes in Rocky Mountain spotted fever and Mediterranean spotted fever.
Am J Clin Pathol, 112 (1999), pp. 159-168
[57.]
T.F. Jones, A.S. Craig, C.D. Paddock, D.B. McKechnie, J.E. Childs, S.R. Zaki, et al.
Family cluster of Rocky Mountain spotted fever.
Clin Infect Dis, 28 (1999), pp. 853-859
[58.]
M.J. Dalton, M.J. Clarke, R.C. Holman, J.W. Krebs, D.B. Fishbein, J.G. Olson, et al.
National surveillance for Rocky Mountain spotted fever, 1981-1992: epidemiologic summary and evaluation of risk factors for fatal outcome.
Am J Trop Med Hyg, 52 (1995), pp. 405-413
[59.]
D.M. Elston.
Tick bites skin rashes.
Curr Opin Infect Dis, 23 (2010), pp. 132-138
[60.]
P. Parola, C.D. Paddock, D. Raoult.
Tickborne rickettsioses around the world: emerging diseases challenging old concepts.
Clin Microbiol Rev, 18 (2005), pp. 719-756
[61.]
J.L. Silber.
Rocky Mountain spotted fever.
Clin Dermatol, 14 (1996), pp. 245-258
[62.]
M. Ramos-e-Silva, A.L. Pereira.
Life-threatening eruptions due to infectious agents.
Clin Dermatol, 23 (2005), pp. 148-156
[63.]
A.R. Thorner, D.H. Walker, W.A. Petri Jr..
Rocky mountain spotted fever.
Clin Infect Dis, 27 (1998), pp. 1353-1359
[64.]
J.M. Kaufmann, A.L. Zaenglein, A. Kaul, M.W. Chang.
Fever and rash in a 3-year-old girl: Rocky Mountain spotted fever.
Cutis, 70 (2002), pp. 165-168
[65.]
O.E. Pacheco, M.R. Giraldo, M. Martínez, M. Hidalgo, I. Echeverri, L. Echevarria, et al.
Estudio de brote febril hemorrágico en el corregimiento de Alto de Mulatos - Distrito Especial Portuario de Turbo Antioquia, enero de 2008.
Inf Quinc Epidemiol Nac, 13 (2008), pp. 145-156
[66.]
C.G. Helmick, K.W. Bernard, L.J. D’Angelo.
Rocky Mountain spotted fever: clinical, laboratory, and epidemiological features of 262 cases.
J Infect Dis, 150 (1984), pp. 480-488
[67.]
Fatal cases of Rocky Mountain spotted fever in family clusters three states, 2003.
MMWR Morb Mortal Wkly Rep, 53 (2004), pp. 407-410
[68.]
J.L. Kirk, D.P. Fine, D.J. Sexton, H.G. Muchmore.
Rocky Mountain spotted fever. A clinical review based on 48 conirmed cases, 1943-1986.
Medicine (Baltimore), 69 (1990), pp. 35-45
[69.]
Rocky Mountain spotted fever -United States, 1990.
MMWR Morb Mortal Wkly Rep, 40 (1991), pp. 451-453
[70.]
L.B. Wilson, W.M. Chowning.
Studies in Pyroplasmosis hominis (“spotted fever” or “tick fever” of the Rocky Mountains).
J Infect Dis, 1 (1904), pp. 31-57
[71.]
L.A. Drage.
Life-threatening rashes: dermatologic signs of four infectious diseases.
Mayo Clin Proc, 74 (1999), pp. 68-72
[72.]
D.J. Sexton, G.R. Corey.
Rocky Mountain “spotless” and “almost spotless” fever: a wolf in sheep's clothing.
Clin Infect Dis, 15 (1992), pp. 439-448
[73.]
D.H. Walker, H.R. Lesesne, V.A. Varma, W.C. Thacker.
Rocky Mountain spotted fever mimicking acute cholecystitis.
Arch Intern Med, 145 (1985), pp. 2194-2196
[74.]
D.H. Walker, F.W. Henderson, G.M. Hutchins.
Rocky Mountain spotted fever: mimicry of appendicitis or acute surgical abdomen?.
Am J Dis Child, 140 (1986), pp. 742-744
[75.]
S.C. Buckingham, G.S. Marshall, G.E. Schutze, C.R. Woods, M.A. Jackson, L.E. Patterson, et al.
Clinical and laboratory features, hospital course, and outcome of Rocky Mountain spotted fever in children.
J Pediatr, 150 (2007), pp. 180-184
[76.]
A. Doyle, K.S. Bhalla, J.M. Jones 3rd, D.M. Ennis.
Myocardial involvement in rocky mountain spotted fever: a case report and review.
Am J Med Sci, 332 (2006), pp. 208-210
[77.]
T.F. Feltes, W.D. Wilcox, W.E. Feldman, D.J. Lipskis, S.L. Carter, G.W. Bugg.
M-mode echocardiographic abnormalities in Rocky Mountain spotted fever.
South Med J, 77 (1984), pp. 1130-1132
[78.]
J.F. Donohue.
Lower respiratory tract involvement in Rocky Mountain spotted fever.
Arch Intern Med, 140 (1980), pp. 223-227
[79.]
C.C. Linnemann Jr., P.J. Janson.
The clinical presentations of Rocky Mountain spotted fever Comments on recognition and management based on a study of 63 patients.
Clin Pediatr (Phila), 17 (1978), pp. 673-679
[80.]
L.G. Kaplowitz, J.J. Fischer, P.F. Sparling.
Rocky Mountain spotted fever: a clinical dilemma.
Curr Clin Top Infect Dis, 2 (1981), pp. 89-108
[81.]
D.H. Walker.
Rocky Mountain spotted fever: a seasonal alert.
Clin Infect Dis, 20 (1995), pp. 1111-1117
[82.]
D.H. Walker.
Rocky Mountain spotted fever: a disease in need of microbiological concern.
Clin Microbiol Rev, 2 (1989), pp. 227-240
[83.]
N.L. Lacz, R.A. Schwartz, R. Kapila.
Rocky Mountain spotted fever.
J Eur Acad Dermatol Venereol, 20 (2006), pp. 411-417
[84.]
J.E. Kaplan, L.B. Schonberger.
The sensitivity of various serologic tests in the diagnosis of Rocky Mountain spotted fever.
Am J Trop Med Hyg, 35 (1986), pp. 840-844
[85.]
K.B. Kirkland, W.E. Wilkinson, D.J. Sexton.
Therapeutic delay and mortality in cases of Rocky Mountain spotted fever.
Clin Infect Dis, 20 (1995), pp. 1118-1121
[86.]
T. Tzianabos, B.E. Anderson, J.E. McDade.
Detection of Rickettsia rickettsii DNA in clinical specimens by using polymerase chain reaction technology.
J Clin Microbiol, 27 (1989), pp. 2866-2868
[87.]
J.S. Dumler, D.H. Walker.
Diagnostic tests for Rocky Mountain spotted fever and other rickettsial diseases.
Dermatol Clin, 12 (1994), pp. 25-36
[88.]
D.J. Sexton, S.S. Kanj, K. Wilson, G.R. Corey, B.C. Hegarty, M.G. Levy, et al.
The use of a polymerase chain reaction as a diagnostic test for Rocky Mountain spotted fever.
Am J Trop Med Hyg, 50 (1994), pp. 59-63
[89.]
A.S. Chapman, J.S. Bakken, S.M. Folk, C.D. Paddock, K.C. Bloch, A. Krusell, et al.
Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis United States: a practical guide for physicians and other health-care and public health professionals.
MMWR Recomm Rep, 55 (2006), pp. 1-27
[90.]
W.N. Herbert, J.W. Seeds, W.L. Koontz, R.C. Cefalo.
Rocky Mountain spotted fever in pregnancy: differential diagnosis treatment.
South Med J, 75 (1982), pp. 1063-1066
[91.]
K.C. Markley, A.B. Levine, Y. Chan.
Rocky Mountain spotted fever in pregnancy.
Obstet Gynecol, 91 (1998), pp. 860
[92.]
S.P. Stallings.
Rocky Mountain spotted fever and pregnancy: a case report and review of the literature.
Obstet Gynecol Surv, 56 (2001), pp. 37-42
[93.]
E.R. Grossman, A. Walchek, H. Freedman.
Tetracyclines and permanent teeth: the relation between dose and tooth color.
Pediatrics, 47 (1971), pp. 567-570
[94.]
D.F. Cale, M.W. McCarthy.
Treatment of Rocky Mountain spotted fever in children.
Ann Pharmacother, 31 (1997), pp. 492-494
[95.]
J.J. Purvis, M.S. Edwards.
Doxycycline use for rickettsial disease in pediatric patients.
Pediatr Infect Dis J, 19 (2000), pp. 871-874
[96.]
B.J. Donovan, D.J. Weber, J.C. Rublein, R.H. Raasch.
Treatment of tickborne diseases.
Ann Pharmacother, 36 (2002), pp. 1590-1597
[97.]
A.S. Chapman, S.M. Murphy, L.J. Demma, R.C. Holman, A.T. Curns, J.H. Mc- Quiston, et al.
Rocky mountain spotted fever in the United States, 1997-2002.
Ann N Y Acad Sci, 1078 (2006), pp. 154-155
[98.]
P.J. Conlon, G.W. Procop, V. Fowler, M.A. Eloubeidi, S.R. Smith, D.J. Sexton.
Predictors of prognosis and risk of acute renal failure in patients with Rocky Mountain spotted fever.
Am J Med, 101 (1996), pp. 621-626
[99.]
L.K. Archibald, D.J. Sexton.
Long-term sequelae of Rocky Mountain spotted fever.
Clin Infect Dis, 20 (1995), pp. 1122-1125
[100.]
E.W. Massey, T. Thames, C.E. Coffey, H.A. Gallis.
Neurologic com-Neurologic complications of Rocky Mountain spotted fever.
South Med J, 78 (1985), pp. 1288-1290
[101.]
J.W. Bergeron, R.L. Braddom, D.L. Kaelin.
Persisting impairment following Rocky Mountain Spotted Fever: a case report.
Arch Phys Med Rehabil, 78 (1997), pp. 1277-1280
[102.]
R.T. Parker, P.G. Menon, A.M. Merideth, M.J. Snyder, T.E. Woodward.
Persistence of Rickettsia rickettsii in a patient recovered from Rocky Mountain spotted fever.
J Immunol, 73 (1954), pp. 383-386
[103.]
J.L. Monteiro.
Estudos sobre o typho exantemático de S Paulo.
Mem Inst Butantan, 6 (1931), pp. 1-136
[104.]
R.N. Angerami, M.R. Resende, A.F. Feltrin, G. Katz, E.M. Nascimento, R.S. Stucchi, et al.
Brazilian spotted fever: a case series from an endemic area in southeastern Brazil: clinical aspects.
Ann N Y Acad Sci, 1078 (2006), pp. 252-254
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