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Inicio Farmacia Hospitalaria (English Edition) Effectiveness and safety of erlotinib in 2 patients with carcinoma of the cervix
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Vol. 33. Núm. 2.
Páginas 96-99 (Enero 2009)
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Vol. 33. Núm. 2.
Páginas 96-99 (Enero 2009)
Acceso a texto completo
Effectiveness and safety of erlotinib in 2 patients with carcinoma of the cervix
Efectividad y seguridad de erlotinib en 2 pacientes con carcinoma de cérvix uterino
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...
I. Pérez Rodrigoa,??
Autor para correspondencia
iperezrodrigo@hotmail.com

Corresponding author.
, R. Albornoz Lópeza, M. Soto Rojasb, I. Fernández Garcíaa, V. Torres Degayóna
a Servicio de Farmacia, Hospital Reina Sofía, Córdoba, Spain
b Servicio de Farmacia, Hospital San Juan de Dios, San José, Costa Rica
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Abstract
Objective

To assess the effectiveness and safety of the use of erlotinib in the treatment of refractory cervical cancer after retrospective analysis of 2 clinical cases.

Methods

The clinical records were assessed for the patients who started treatment with erlotinib, on a compassionate-use basis, with an oral dosage of 150mg/day until June 2008. The pharmacy dispensing records were also assessed to evaluate adherence to treatment. Progression-free survival was assessed and adverse reactions were recorded in the medical records.

Results

Three patients with recurrent, advanced cervical cancer were candidates for treatment with erlotinib, 2 of whom were only starting treatment. In both cases, the women had previously received between 3 and 4 different treatment lines. Progression-free survival was 6 months and 4 months in each case. The adverse reactions to the treatment were slight.

Conclusions

Erlotinib presented some similar results to those obtained from cisplatin doublets in women with refractory cervical cancer, with minor adverse effects. However, these results need to be corroborated in the clinical studies field on a wider section of the population.

Keywords:
Erlotinib
Carcinoma of the cervix
Compassionate-use
Effectiveness
Safety
Resumen
Objetivo

Evaluar la efectividad y la seguridad del tratamiento con erlotinib en cáncer de cérvix uterino refractario a través del análisis retrospectivo de 2 casos clínicos.

Métodos

Se revisaron las historias clínicas de las pacientes que iniciaron tratamiento con erlotinib vía oral a dosis de 150mg/día como uso compasivo hasta junio del 2008, así como los registros de dispensación de farmacia para valorar la adherencia al tratamiento. Se evaluó la supervivencia libre de progresión y se recogieron las reacciones adversas descritas en la historia clínica.

Resultados

Tres pacientes con cáncer de cérvix avanzado recurrente fueron candidatas a tratamiento con erlotinib, 2 de las cuales iniciaron tratamiento. En ambos casos las mujeres habían recibido entre 3 y 4 líneas de tratamiento previas. La supervivencia libre de progresión fue de 6 y 4 meses en cada caso. Las reacciones adversas al tratamiento fueron leves.

Conclusiones

El erlotinib presentó unos resultados similares a los logrados con los dobletes de cisplatino en mujeres con cáncer de cérvix refractario, con leves efectos adversos. Sin embargo, habrá que corroborar estos resultados en el ámbito de los ensayos clínicos con poblaciones más amplias.

Palabras clave:
Erlotinib
Carcinoma de cérvix
Uso compasivo
Efectividad
Seguridady
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