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Vol. 13. Issue 4.
Pages 206-210 (October - December 1977)
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Vol. 13. Issue 4.
Pages 206-210 (October - December 1977)
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Carcinoma embrionario de mediastino anterior. Presentacion de un caso y revision de la literatura
Embryonic carcinoma of anterior mediastinum. Presentation of one case and review of bibliography
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E. Pérez Rodríguez, A. Sastre Castillo, M. Sánchez González, H. Verea Hernando, H. Oliva, F. Lahoz Navarro, J. Vallejo Galbete
Servicio de Neumología. Fundación Jiménez Díaz. Madrid
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Resumen

Presentamos un caso de un tumor embrionario con predominio de estructuras del seno endodérmico, que consideramos encuadrable dentro del carcinoma embrionario. No hemos encontrado referido ningún otro caso en la literatura nacional. Está localizado en mediastino anterior y lleva una supervivencia en la actualidad de 9 meses. La respuesta al tratamiento fue aceptable, aunque no lo suficientemente satisfactoria, y fue valorada según criterios clínicos, radiológicos, broncoscópicos y analíticos, entre los que cabe destacar su control con la monitorización de las alfaproteínas, las cuales cursaron con niveles mucho más altos que los descritos en la literatura, y sus niveles como respuesta al tratamiento han descendido de forma muy acentuada.

Creemos por ello, que las determinaciones de alfa-fetoproteínas y gonadotropinas por radioinmunoensayo, así como otros test de inmunidad celular, pueden servir de índice, lo suficientemente precoz, para poner en evidencia una mala respuesta a la terapéutica, o bien orientar unos criterios terapéuticos más eficaces.

Summary

The authors presented a case of embryonic tumor with predominance of structures of entodermal sinus that they feel can be placed within the framework of embryonic carcinoma. No reference to any other case was found in the national bibliography. The tumor is located in the anterior mediastinum and at the time of writing this paper had survived for 9 months. The response to treatment was acceptable, although not sufficiently satisfactory, and was evaluated according to clinical, radiological, bronchoscopic and analytical criteria. Especially worthy of note was its control using monitorization of the alpha-proteins, which ran with mucho higher levels than those described in medical literature. In response to treatment, its levels decreased in a very accented way.

Therefore, the authors feel that the detenninations of alpha-fetoproteins and gonadotropins by radio-immune test, as well as other test of cellular immunity can serve as an Index, sufficiently precocious, to make a bad response to therapy evident, or rather to orient more effective therapeutical criteria.

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Bibliografia
[1.]
M.A. Luna, J. Valenzuela Tamariz.
Germcell tumors of the mediastinum, postmortem findings.
Am. Clin. Pat, 65 (1976), pp. 450
[2.]
Martini N., R.B. Golbey, S.I. Haidu, W.F. Withmire, E.J. Beatile tr.
Primary mediastinal germ cell tumors.
Cáncer, 33 (1974), pp. 763
[3.]
A. Schaitz, W. Seial, B. Castleian.
Mediastinal germinoma. A study of 21 cases with an excellent prognosis.
Cáncer, 30 (1972), pp. 1189
[4.]
E.A. Sickies, R.E. Belliviau, P.H. Wieriix.
Primary mediastinal choriocarcinoma in the male.
Cáncer, 33 (1974), pp. 1196
[5.]
N.B. Friedian.
The comparative morphogenesis of extra-genital and gonadal teratoid tumors.
Cáncer, 4 (1951), pp. 265
[6.]
R.W. Huntingion Jr., W.K. Bullick.
Yolk sac tumors of extragonadal origin.
Cáncer, 25 (1970), pp. 1368
[7.]
B. Peiion.
Embryonal teratocarcinoma of the mediastinum in a woman with foci of anaplastic cells simulating chorioepitelioma.
Chest, 58 (1970), pp. 169
[8.]
J.D. iox.
Primary malignant germinal tumors of the mediastinum. A study of 24 cases.
Cáncer, 36 (1975), pp. 1 162
[9.]
G. Priociau.
Endodermal sinus tumor of the pineal regior.
Cáncer, 38 (1976), pp. 2489
[10.]
E.M. Meaies, E.M. Briigs.
Occult seminoma of the testis masquerading as primary extragonadal germinal neoplasms.
Cáncer, 30 (1972), pp. 301
[11.]
M.H. Suiak.
Classification of different pathology types.
JAMA, 213 (1970), pp. 91
[12.]
T.A. Waldminn, K.R. Imc Intire.
The use of a radioinmunoenssay for alfafetoprotein in the diagnosis of malignancy.
Cáncer, 34 (1974), pp. 1510
[13.]
A. Talerian, W.G. Haije.
Alfafetoprotein and germ-cell tumors: A possible role of yolk sac tumor in production of alphafetoprotein.
Cáncer, 34 (1974), pp. 1722
[14.]
G.D. Braunstiin, K.R. Mc Intire, T.A. Waldminn.
Discordance of human chorionic gonadotropin and alphafetoprotein in testicular teratocarcinoma.
Cáncer, 31 (1973), pp. 1065
[15.]
C.G. Bergstrind, B. Ciar.
Demonstration of a new protein fraction in serum from human fetus.
Scand. J. Lab. Invest, 8 (1956), pp. 174
[16.]
J.B. Smith, R.T. O’Neill.
Alphafetoprotein occurrance in germinal cell and liver malignances.
Am. J. Med., 51 (1972), pp. 767
[17.]
M. Balias.
Yolk sac carcinoma of the ovary with alpha-fetoprotein in serum and ascitic fluid demonstrated by inmunoosmoforesis.
Am. Jmtr. Clin. Pat., 57 (1972), pp. 511
[18.]
D. Gitiin, A. Periceili, G.M. Gitiin.
Synthesis of alpha-fetoprotein by liver, yolk sac and gastrointestinal tract of the human conceptus.
Cáncer Res, 32 (1972), pp. 979
[19.]
M.D. Nefzier, F.K. Mostifi.
Survival after surgery for germinal inalignancies of the testis I rates of survival in tumors groups.
Cáncer, 30 (1972), pp. 1225
[20.]
A.R. Wychuiis, W.S. Paine, O.T. Clagitt, L.B. Woolier.
Surgical treatement of mediastinal tumors. A 40 year experience.
Jonr. Thorac. Cardiov. Surq., 62 (1971), pp. 379
[21.]
A. Neuhius, J.J. Rohwedier, H. Maier, M.H. Weich.
Anterior mediastinal mass in a young man (Roentgenogram of the month).
Chest, 70 (1976), pp. 641
Copyright © 1977. Sociedad Española de Neumología y Cirugía Torácica
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