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Vol. 55. Núm. 1.
Páginas 7-20 (Enero 2003)
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Vol. 55. Núm. 1.
Páginas 7-20 (Enero 2003)
Acceso a texto completo
Estudio ultraestructural del comportamiento de xenoinjertos vasculares sometidos a dietas hiperlipídicas
Ultrastructural study about the effect of the hiperlipidic dietsoncriopreserved vascular xenografts
Estudo ultra-estrutural do comportamento dosxenoenxertos vasculares submetidos adietas hiperlipídicas
Visitas
2674
M.J. Vallina-Vázquez
Autor para correspondencia
mjvallina@terra.es

Correspondencia: Dr. Manuel Javier Vallina Vázquez. Co rín Tellado, 8, 5.° B. E-33204 Gijón.
, F.J. Mateos-Otero, M.V. Diago, V.M. Gutiérrez-Alonso, C. Vaquero-Puerta
Unidad de Investigación Angiológica. Departamento de Cirugía Experimental. Facultad de Medicina. Universidad de Valladolid. Valladolid, España.
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Resumen

Se ha procedido al análisis ultraestructural de la pared de la aorta nativa y de xenoinjertos criopreservados implantados enratas de la raza Wistar-Lewis sometidas a dietas aterogénicas. Paraello se han establecidos distintos grupos de estudio, iguales en número y con una distribución al azar de los individuos. Se trata de determinar si las lesiones ateromatosas inducidas por la alimentación hiperlipídica son idénticas en ambos tipos de vasos arteriales opresentan diferencias significativas. Una vez finalizado el período de investigación, los resultados obtenidos sugieren que los injertos heterólogos son más sensibles a la acción patógena de las dietas ricas en grasas. La aplicación de la microscopía electrónica, tanto de transmisión como de barrido, hapermitido valorarde forma idónea el comportamiento de los implantes.

Palabras clave:
Aterogénesis
Bioprótesis
Dietas hiperlipídicas
Injertos heterólogos
Microscopía electrónica
Xenoinjertos
Summery

One proceeds to the ultrastructural analysis of the wall of the native aorta and the criopreservedxenografts, implanted in Wistar-Lewis rats submitted to aterogenic diets. For this, different groups of study are established, in equal number and with a distribution of the individuals at random. It is a question of determining if the injuries induced by the hiperlipidic nourishment are identical in both types of arterial vessels or if they present significant differences. Once the period of investigation is finished, the obtained results suggest that the heterologous grafts are more sensitive to the pathogenic action of the diets rich in fats. The application ofthe electronic microscopy, both of transmission and of sweep, has allowed to value the behaviour ofthe implants in a suitable form.

Key words:
Atherogenic
Bioprosthesis
Hiperlipidics diets
Microscopy electron
Transplantation heterologous
Xenografts
Resumo

Procede-se á análise ultra-estrutural da parede da aorta nativa e de xenoenxertos criopreservados, implantados em ratos da raca Wistar-Lewis submetidas a dietas aterogénicas. Para o efeito estabeleceram-se grupos de estudo distintos, iguais em número e com uma distribui¸ão aleatória dos indivíduos. Trata-se de determinar se as lesões ateromatosas induzidas pela alimentação hiperlipídica são idênticas em ambos os tipos de vasos arteriais ou se apresentam diferenças significativas. Uma vez concluído o período de investigação, os resultados obtidos sugerem que os enxertos heterólogos são mais sensíveis á acção patogénica das dietas ricas em gorduras. A aplicação da microscopia electrónica, tanto de transmissão como de varredura, permitiu avaliar adequadamente o comportamento dos implantes.

Palavras chave:
Aterogénese
Bioprótese
Dietas hiperlipídicas
Enxertos heterólogos
Microscopia electrónica
Xenoenxertos
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Estetrabajodeinvestigación harecibido una ayudapara eldesarrollo deproyectos de investigación por el Fondo de Investigación Sanitaria (FIS) N° Exp. 00/0104.

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