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array:22 [ "pii" => "S0210480604730600" "issn" => "02104806" "doi" => "10.1016/S0210-4806(04)73060-0" "estado" => "S300" "fechaPublicacion" => "2004-01-01" "aid" => "73060" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2004" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Urol Esp. 2004;28:161-74" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1086 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 735 "PDF" => 343 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480604730612" "issn" => "02104806" "doi" => "10.1016/S0210-4806(04)73061-2" "estado" => "S300" "fechaPublicacion" => "2004-01-01" "aid" => "73061" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2004;28:175-214" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2517 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 1242 "PDF" => 1265 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "La vasectomía: estudio de 300 intervenciones. revisión de la literatura nacional y de sus complicaciones" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "175" "paginaFinal" => "214" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "P. Romero PéRez, F.J. Merenciano Cortina, W. Rafie Mazketli, M. Amat Cecilia" "autores" => array:4 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Romero PéRez" ] 1 => array:2 [ "nombre" => "F.J." "apellidos" => "Merenciano Cortina" ] 2 => array:2 [ "nombre" => "W." "apellidos" => "Rafie Mazketli" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Amat Cecilia" ] ] ] 1 => array:2 [ "autoresLista" => "MªC. MartíNez HernáNdez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "MªC." "apellidos" => "MartíNez HernáNdez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480604730612?idApp=UINPBA00004N" "url" => "/02104806/0000002800000003/v1_201304251728/S0210480604730612/v1_201304251728/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Xenotrasplante renal cerdo hdaf-babuino. Experiencia y revisión" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "161" "paginaFinal" => "174" ] ] "autores" => array:7 [ 0 => array:4 [ "autoresLista" => "M. González martín" "autores" => array:1 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "González martín" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Urología" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. M. González Martín Servicio de Urología Hospital Juan Canalejo Xubias de Arriba, 84 15009 La Coruña" ] ] ] 1 => array:3 [ "autoresLista" => "J. García buitrón" "autores" => array:1 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "García buitrón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Coordinación de Trasplantes" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "autoresLista" => "A. Alonso hernández" "autores" => array:1 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Alonso hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "autoresLista" => "A. Centeno cortés, E. López peláez" "autores" => array:2 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Centeno cortés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] 1 => array:3 [ "nombre" => "E." "apellidos" => "López peláez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Unidad de Investigación" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "autoresLista" => "E. Vázquez martul, J. Mosquera reboredo" "autores" => array:2 [ 0 => array:3 [ "nombre" => "E." "apellidos" => "Vázquez martul" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Mosquera reboredo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica" "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "autoresLista" => "I. Requejo isidro" "autores" => array:1 [ 0 => array:3 [ "nombre" => "I." "apellidos" => "Requejo isidro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Radiodiagnóstico" "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] ] ] 6 => array:3 [ "autoresLista" => "R. Máñez mendiluce" "autores" => array:1 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Máñez mendiluce" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Director Programa Xenotrasplante. Hospital Universitario Juan Canalejo. Fundación Barrié de la Maza. La Coruña" "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-12-15" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec87100" "palabras" => array:4 [ 0 => "Xenotrasplante" 1 => "Babuino" 2 => "Cerdo" 3 => "Riñón" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec87099" "palabras" => array:4 [ 0 => "Xenotrasplant" 1 => "Baboon" 2 => "Pig" 3 => "Kidney" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Xenotrasplante renal cerdo hdaf-babuino. experiencia y revisión</p> <span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El xenotrasplante renal puede representar la solución a la creciente demanda de órganos. Presentamos nuestra experiencia y revisamos el estado actual del xenotrasplante.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Hemos realizado 20 xenotrasplantes de riñón de cerdo transgénico hDAF a babuino con cuatro protocolos de inmunosupresión. Todos los receptores recibieron GAS 914.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Grupo A: Ciclofosfamida, Ciclosporina, Micofenolato y Corticosteroides (n=10).</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Grupo B: Ciclofosfamida, Ciclosporina, FTY 720 y Corticosteroides (n=3).</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Grupo C: Basiliximab, Ciclosporina, FTY 720 y Corticosteroides (n=3).</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Grupo D: Basiliximab, FTY 720, Everolimus y Corticosteroides (n=4).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La supervivencia de los xenoinjertos osciló entre 1 y 31 días. La supervivencia en relación con los protocolos de inmunosupresión no fue significativamente diferente: A) 7 días, B) 8 días, C) 8 días, D) 9 días.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">1. Los tiempos de isquemia fría influyen en la función inicial de los riñones, no en su evolución final.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">2. El rechazo hiperagudo ha sido superado con la utilización de cerdos transgénicos, produciéndose el fracaso por rechazo humoral agudo, no controlado con los protocolos de inmunosupresión actuales.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">3. Es preciso investigar y desarrollar otros protocolos de inmunosupresión que nos permitan un mejor conocimiento de la fisiología del xenoinjerto y de su potencial riesgo de transmisión de enfermedades.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Renal xenotrasplantation of hdaf pig to baboons. experience and review</p> <span class="elsevierStyleSectionTitle">Summary</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">The renal xenotrasplant could be the solution on the demand of organs for transplantation. We present here our experience and review the actual status of the xenotransplant.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">We have done 20 xenotransplants from transgenic pig h DAF to baboons, with four protocols of inmunosupression. All the hosts were treated with GAS 914.</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Group A: Cyclophosphamide, Cyclosporine, Mycophenolate, and Steroids (n=10).</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Group B: Cyclophosphamide, Cyclosporine, FTY 720, and Steroids (n=3).</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Group C: Basiliximab, Cyclosporine, Mycophenolate, and Steroids (n=3).</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Group D: Basiliximab, FTY 720, Everolymus, and Steroids (n=4).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">The duration of the xenografts ranged between 1 and 31 days. The function of the xenografts in relation to the type of inmunosupression were not significantly different: A) 7 days, B) 8 days, C) 8 days, and D) 9 days.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">1. The cold ischemic time of the graft, has influence in the initial function of the kidneys but not in the evolution and duration of the graft.</p><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">2. The hyperacute rejection has been overcome with the utilization of transgenic pigs. The graft failure was due to acute humoral rejection that was not aborted by the actual inmunosupressors.</p><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">3. It is necessary to develop new inmunosupression protocols, through new knowledge of their pharmacology and the physiology of the xenografts, and at the same time it is important to avoid the potential risk of transmission of animal infections.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:41 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Discordant organ xenotransplantation in primates. World experience and current status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Lambrigts" 1 => "D.H. Sachs" 2 => "D.K.C. 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