TY - JOUR T1 - Unfavorable cytokine and adhesion molecule profiles during and after pregnancy, in women with gestational diabetes mellitus JO - Endocrinología, Diabetes y Nutrición T2 - AU - Roca-Rodríguez,María del Mar AU - López-Tinoco,Cristina AU - Fernández-Deudero,Álvaro AU - Murri,Mora AU - García-Palacios,María Victoria AU - García-Valero,María del Amor AU - Tinahones,Francisco José AU - Aguilar-Diosdado,Manuel SN - 25300164 M3 - 10.1016/j.endinu.2016.10.003 DO - 10.1016/j.endinu.2016.10.003 UR - https://www.elsevier.es/es-revista-endocrinologia-diabetes-nutricion-13-articulo-unfavorable-cytokine-adhesion-molecule-profiles-S2530016416300052 AB - BackgroundGestational diabetes mellitus is a significant risk factor for metabolic syndrome and cardiovascular disease. AimsTo assess the relationships between components of the metabolic syndrome and cytokine and adhesion molecule levels in women with GDM during pregnancy and after delivery. Patients and methodsA prospective case–control study on a sample of 126 pregnant women (63 with and 63 without gestational diabetes mellitus). In an intra-subject analysis, 41 women with history of gestational diabetes mellitus and 21 controls were re-assessed in the postpartum period. Clinical data and levels of cytokines and adhesion molecules were recorded during weeks 24–29 of pregnancy and 12 months after delivery. ResultsIn the postpartum period, there were significantly higher levels of tumor necrosis factor alpha in both cases and controls, and of adiponectin in controls. Cases showed higher leptin levels, with no significant differences during and after pregnancy. No significant differences were seen in adhesion molecules and interleukin-6 between cases and controls during pregnancy and in the postpartum period, but levels of both were higher in cases. During pregnancy and after delivery, adiponectin decreased in cases and increased in controls. Significant positive correlations were seen between adiponectin and fasting blood glucose levels and vascular cell adhesion molecule-1, and also between leptin and tumor necrosis factor alpha levels. ConclusionsThe results suggest that increased inflammation and transient hyperglycemia during pregnancy would represent a latent form of metabolic syndrome, with an increased risk for type 2 diabetes mellitus and future cardiovascular disease. ER -