TY - JOUR T1 - Severe sleep apnea–hypopnea syndrome is related to left ventricle dysfunction and hypertrophy in acromegalic patients JO - Endocrinología y Nutrición T2 - AU - Sanchez-Ortiga,Ruth AU - Climent,Vicente AU - Sanchez-Tejada,Laura AU - Candela,Alfredo AU - Pico,Antonio SN - 15750922 M3 - 10.1016/j.endonu.2015.05.007 DO - 10.1016/j.endonu.2015.05.007 UR - https://www.elsevier.es/es-revista-endocrinologia-nutricion-12-articulo-severe-sleep-apneahypopnea-syndrome-is-S1575092215001515 AB - ObjectiveTo assess whether sleep apnea-hypopnea syndrome (SAHS) is a risk factor for development of acromegalic cardiomyopathy. MethodsA descriptive, cross-sectional study of 32 patients with acromegaly (15 categorized as non-controlled-NCA and 17 as controlled-CA) compared to 20 matched controls (by sex, age, and BMI) referred to the pulmonology department for suspected SAHS. Polysomnography, echocardiography (M-mode, 2-dimensional, and Doppler), and 12-lead electrocardiography were performed in all participants. Development of cardiac morbidity (ischemia heart disease or heart failure) was evaluated after 7 years. ResultsSAHS was diagnosed in 81.3% of patients with acromegaly and 85% of controls. Mild SAHS was more common in CA than in NCA patients (31.3% vs. 0%, p=0.048). There was a trend to greater prevalence of left ventricular diastolic dysfunction (LVDD) in acromegalic patients as compared to controls (58.1% vs. 30%, p=0.05). Presence of severe SAHS in patients with acromegaly was related to greater risk of LVDD (90.9% vs. 40%, p=0.008; OR 2.3 [1.3–4.0]), LV hypertrophy (55.6% vs. 10.5%, p=0.02; OR 5.3 [1.3–22.2]), and cardiac events (87.5% vs. 35.6%; p=0.01; OR 7.53 [1.07–53.24]). ConclusionSAHS is highly prevalent in patients with acromegaly. Only in these patients was severe SAHS associated to hypertrophy, LV diastolic dysfunction, and cardiac events. ER -