TY - JOUR T1 - Immunosuppression for inflammatory bowel disease does not influence Epstein–Barr viral load in the short-term JO - Gastroenterología y Hepatología T2 - AU - Rodríguez-Lago,Iago AU - Merino,Olga AU - López de Goicoechea,María José AU - Aranzamendi,Maitane AU - Zubiaurre,Leire AU - Muro,Nerea AU - Ortiz de Zárate,Jone AU - Cilla,Gustavo AU - Cabriada,José Luis SN - 02105705 M3 - 10.1016/j.gastrohep.2019.03.016 DO - 10.1016/j.gastrohep.2019.03.016 UR - https://www.elsevier.es/es-revista-gastroenterologia-hepatologia-14-articulo-immunosuppression-for-inflammatory-bowel-disease-S0210570519301591 AB - IntroductionImmunomodulators and biologics are two of the main drugs used for the treatment of inflammatory bowel disease (IBD). Some of these agents have been associated with certain infections and lymphoproliferative disorders, including Epstein–Barr virus (EBV) infection. Our aim was to determine the influence of immunosuppression in the EBV viral load in patients with IBD. Materials and methodsWe prospectively included naïve patients with IBD who were starting immunosuppressive therapy in four IBD Units. All patients were assessed at baseline and four months after starting immunosuppression for clinical disease activity, biomarkers, EBV serology (IgM VCA, IgG VCA and IgG EBNA) and viral load. ResultsThirty-two patients were included. At baseline, all patients showed positive results for IgG VCA or IgG EBNA with undetectable EBV viral load. No patient showed detectable EBV viral load after starting the immunosuppressive therapy. ConclusionImmunosuppression did not influence on EBV viral load in the short-term in naïve IBD patients. ER -