TY - JOUR T1 - Therapeutic guidelines on ulcerative colitis: A GRADE methodology based effort of GETECCU JO - Gastroenterología y Hepatología T2 - AU - Gomollón,Fernando AU - García-López,Santiago AU - Sicilia,Beatriz AU - Gisbert,Javier P. AU - Hinojosa,Joaquín SN - 02105705 M3 - 10.1016/j.gastrohep.2012.09.006 DO - 10.1016/j.gastrohep.2012.09.006 UR - https://www.elsevier.es/es-revista-gastroenterologia-hepatologia-14-articulo-therapeutic-guidelines-on-ulcerative-colitis-S021057051200307X AB - Background and aimEvidence-based clinical guidelines on Ulcerative colitis (UC) have been developed through a consensus, while GRADE methodology is the current standard for guideline development. This is the first one based on GRADE methodology on UC. MethodsFollowing GRADE methodology, the Spanish Group of Ulcerative Colitis and Crohn's disease (GETECCU) have developed a guideline on UC treatment. After selection of relevant clinical scenarios, 32 clinical questions were chosen and recommendations were established. ResultsIn 2 questions no recommendation was possible. Twenty-two actions were recommended for, 14 strongly and 8 weakly. However, in 8 questions a recommendation against doing something was obtained, weak in 5 and strong in 3. The majority of recommendations were based on moderate quality evidence, and only 5 on high-quality evidence. ConclusionsWith GRADE methodology we find a clear recommendation on possible actions in most clinical decisions in UC treatment, but much more clinical high-quality research is needed. ER -