TY - JOUR T1 - Serum cytokines in ANCA-associated vasculitis: Correlation with disease-related clinical and laboratory findings JO - Medicina Clínica T2 - AU - Krajewska Wojciechowska,Joanna AU - Krajewski,Wojciech AU - Kościelska-Kasprzak,Katarzyna AU - Zatoński,Tomasz SN - 00257753 M3 - 10.1016/j.medcli.2020.07.036 DO - 10.1016/j.medcli.2020.07.036 UR - https://www.elsevier.es/es-revista-medicina-clinica-2-articulo-serum-cytokines-in-anca-associated-vasculitis-S0025775320306540 AB - BackgroundAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a systemic, autoimmune disease. Cytokine dysregulation during active disease and clinical remission, reflects significant immunological activity in various disease stages, and might be responsible for the potential relapse of ANCA-vasculitis. ObjectivesThis study aimed to screen serological profiles in active granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), and to determine their associations with clinical characteristics. Materials and methodsSerum IL-10, IL-12, IL-17, IL-21, IL-23, B cell activating factor (BAFF) concentrations were determined by Quantikine HS ELISA in 71 patients, 47 with GPA and 24 with MPA, and compared with 16 healthy controls. Subsequently, the correlations between serum IL-10, IL-12, IL-17, IL-21, IL-23, BAFF levels, and both laboratory and clinical abnormalities were investigated. ResultsBAFF levels were significantly higher in GPA than MPA, and healthy controls. IL-10 and BAFF levels were elevated in GPA patients with pulmonary involvement. Higher BAFF levels might reflect severe GPA. IL-10 and IL-12 levels were higher in MPA than GPA. In MPA, IL-10 levels were highest in patients with short disease duration, and young individuals. IL-12 correlated positively with BVAS and was elevated in patients with cardiovascular involvement and nasal S. aureus carriers. ConclusionsIn MPA, IL-12 correlates positively with disease activity, and is significantly increased in patients with cardiovascular involvement and nasal S. aureus carriers. Increased IL-10 is observed in young MPA patients and in those with short MPA duration. Elevated BAFF and IL-10 levels are associated with pulmonary involvement in GPA. High BAFF levels might reflect severe GPA. ER -