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Vol. 21. Issue 1.
Pages 23-40 (January - June 2020)
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Vol. 21. Issue 1.
Pages 23-40 (January - June 2020)
Review article
DOI: 10.1016/j.vacune.2020.02.002
Vaccination with conjugate vaccines against pneumococcal disease: What really matters
Vacunación frente a la enfermedad neumocócica con vacunas conjugadas: ¿qué es lo que verdaderamente importa?
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J.C.De Moraesa, X.M. Pérez Porcunab, J. Nieto-Guevarac,
Corresponding author
javier.a.nieto@gsk.com

Corresponding author.
, A. Eismand, B. Torresd, J.L. Gonzalez Redondod, X. Saez-Llorense
a Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, Brazil
b EAP Sta Eugènia, Pediatria d’Osona, Institut Català de la Salut, Barcelona, Spain
c GSK, Departamento médico, City of Knowledge, Panama City, Panama
d GSK, Departamento médico, Tres Cantos, Madrid, Spain
e Servicio de Infectología, Hospital del Niño Dr. José Renán Esquivel, Panama City, Panama
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Tables (4)
Table 1. Impact PHiD-CV and PCV VNC13 on the incidence of IPD in children <5 years.
Table 2. Impact of PHiD-CV and PVC13 on pneumonia.
Table 3. Impact of PHiD-CV and PCV13 on AOM.
Table 4. Cross-protection of PHiD-CV against 19A and 6A serotypes in vaccinated children.
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Abstract

Certain vaccine-preventable diseases such as invasive pneumococcal disease (IPD), pneumonia, and otitis media (OM) are caused by Streptococcus pneumoniae. Pneumococcal conjugate vaccines (PCVs) have significantly contributed to reduce the burden of pneumococcal disease. The evidence from published literature indicates that the pneumococcal Haemophilus influenzae protein D conjugate vaccine and the 13-valent PCV have similar impact against pneumococcal disease burden. This opinion has been adopted by independent recognised public health entities such as the World Health Organization and the Pan American Health Organization. The net effect is limited by the continuous replacement of serotypes not contained in the formulations. The studies focusing on specific serotypes should recognise that the main goal of the vaccination with PCVs is to reduce the overall burden of disease regardless the serotypes already contained into formulation.

Keywords:
Streptococcus pneumoniae
Pneumococcal infection
Pneumonia
Otitis media
Pneumococcal vaccines
Population impact
Resumen

Ciertas enfermedades prevenibles con vacunas, como la enfermedad neumocócica invasiva (ENI), la neumonía y la otitis media (OM) son causadas por Streptococcus pneumoniae. Las vacunas neumocócicas conjugadas (VNC) han contribuido de manera considerable a reducir la carga de la enfermedad neumocócica. La evidencia bibliográfica publicada indica que la vacuna neumocócica conjugada con la proteína D de Haemophilus influenzae y la VNC de 13 valencias tienen un impacto comparable sobre la carga de la enfermedad neumocócica. Esta opinión ha sido emitida por entidades independientes y reconocidas de salud pública como la Organización Mundial de la Salud (OMS) y la Organización Panamericana de la Salud (OPS). El efecto neto se ve limitado por el reemplazo continuo de serotipos no incluidos en las formulaciones. Los estudios centrados en serotipos concretos deberían reconocer que el objetivo principal de la vacunación con las VNC es reducir la carga global de la enfermedad, independientemente de los serotipos contenidos en la formulación.

Palabras clave:
Streptococcus pneumoniae
Infección neumocócica
Neumonía
Otitis media
Vacunas antineumocócicas
Impacto poblacional

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