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Vol. 23. Issue S2.
COVID 19 & vaccines: Development and practice
Pages S32-S35 (September - December 2022)
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Vol. 23. Issue S2.
COVID 19 & vaccines: Development and practice
Pages S32-S35 (September - December 2022)
Original
Risks of adverse outcomes in COVID-19 patients and vaccination status in a secondary hospital in Spain
Riesgo de resultados adversos en los pacientes de COVID-19 y situación de la vacunación en un hospital de atención secundaria en España
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Christine Giesen
Corresponding author
cgiesen@gmx.net

Corresponding author.
, Carmen Saa-Requejo, Inmaculada Lopez-Carrillo, Angelica Ortega-Torres, Cristina García-Fernández, COVID-19 Vaccination Team
Preventive Medicine Unit, Infanta Sofia University Hospital, San Sebastián de los Reyes, Spain
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Tables (3)
Table 1. Percentage of COVID-19 cases and hospitalization by age groups according to their vaccination situation at our centre, Jan 01-Aug 10, 2021. *p < 0.05.
Table 2. Percentage of admitted patients' COVID-19 infection outcomes according to their vaccination situation at our centre, Jan 01-Aug 10, 2021.
Table 3. Relative risk of hospitalization and death among different age groups between vaccinated and unvaccinated cases at our centre, Jan 01-Aug 10, 2021.
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Special issue
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Vol. 23. Issue S2

COVID 19 & vaccines: Development and practice

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Abstract
Introduction

In December 2020, vaccination against SARS-CoV-2 started in Spain. Until March 2022, 91.1% of the target population was vaccinated. The objective of the study is to describe the characteristics of patients with SARS-CoV-2 infection, the risk of serious outcomes and their vaccination status.

Material and methods

Retrospective longitudinal analytical observational study. Demographic characteristics and outcomes of COVID-19 infections and vaccination history from 01/01/2021–08/10/2021 were collected from electronic medical records and the Unified Vaccination Registry. Data analysis was performed with Excel and Stata 16.

Results

4161 COVID-19 cases were detected; of which 185 (4.5%) had received a complete vaccination schedule. The most affected age group was 80–89 years (34.1%). 1697 patients were hospitalized, of whom 78 (4.6%) had been vaccinated against SARS-CoV-2. No patient admitted to the ICU had a history of vaccination. The mean hospitalization time in unvaccinated patients was 11 days (95% CI -41.54–63.54) compared to 8.5 days (95% CI 7.04–9.96) in vaccinated patients. The relative risk of hospitalization in vaccinated patients compared to unvaccinated patients for the age group 40 to 59 years was 0.29 (95% CI 0.11–0.72) and 0.77 (95% CI 0.67–0). 0.90) for people over 60 years of age.

Conclusions

The risk of hospitalization and death was lower in vaccinated patients compared to unvaccinated patients in the age groups 40–59 and older than 60 years. This finding supports current clinical evidence.

Keywords:
COVID-19
SARS-CoV-2
Vaccine
Prevention
Resumen
Introducción

En diciembre 2020 inició la vacunación frente al SARS-CoV-2 en España. Hasta principios de marzo 2022 el 91,1% de la población diana ha sido vacunada. El objetivo del estudio es describir las características de los pacientes con infección por SARS-CoV-2, el riesgo de desenlaces graves y el estado de vacunación.

Material y métodos

Estudio observacional analítico longitudinal retrospectivo. Se recogieron características demográficas y desenlace de infecciones COVID-19 de casos confirmados y sus antecedentes de vacunación desde 01/01/2021–10/08/2021 de las historias clínicas electrónicas y del Registro Unificado de Vacunación. El análisis de datos se realizó con Excel y Stata 16.

Resultados

Se detectaron 4161 casos COVID-19; 185 (4,5%) recibieron pauta de vacunación completa. El grupo de edad más afectado fue 80–89 años (34,1%). 1697 pacientes hospitalizaron, de los cuales 78 (4,6%) recibieron pauta de vacunación completa. Ningún paciente ingresado en UCI tenía antecedentes de vacunación. El tiempo medio de hospitalización en no vacunados fue de 11 días (IC95% -41,54-63,54) frente a 8,5 días (IC95% 7,04-9,96) en vacunados. El riesgo relativo de hospitalización en vacunados respecto a no vacunados para el grupo de edad de 40 a 59 años fue de 0,29 (IC95% 0,11-0,72) y de 0,77 (IC95% 0,67-0,90) para las personas de más de 60 años.

Conclusiones

El riesgo de hospitalización y muerte fue menor en los pacientes vacunados en comparación con los no vacunados en los grupos de edad 40–59 y mayores de 60 años. Este hallazgo está de acuerdo con los datos de la evidencia clínica actual.

Palabras clave:
COVID-19
SARS-CoV-2
Vacuna
Prevención

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