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Original article
DOI: 10.1016/j.rpsmen.2018.03.001
Oxidative stress biomarkers and clinical dimensions in first 10 years of schizophrenia
Biomarcadores de estrés oxidativo y dimensiones clínicas en los 10 primeros años de esquizofrenia
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Leticia González-Blancoa,b,c,
Corresponding author
leticiagonzalezblanco@gmail.com

Corresponding author.
, María Paz García-Portillaa,b,c, Leticia García-Álvareza,c, Lorena de la Fuente-Tomása, Celso Iglesias Garcíaa,c,d, Pilar A. Sáiza,b,c, Susana Rodríguez-Gonzáleze, Ana Coto-Montese, Julio Bobesa,b,c
a Área de Psiquiatría, Universidad de Oviedo, Oviedo, Spain
b Servicio de Salud del Principado de Asturias, Oviedo, Spain
c Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain
d Servicio de Salud del Principado de Asturias, Langreo, Spain
e Departamento de Morfología y Biología Celular, Universidad de Oviedo, Oviedo, Spain
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Table 1. Demographic and clinical characteristics of patients with schizophrenia (SZ) and healthy controls (HC).
Table 2. Comparison of metabolic syndrome and oxidative stress biomarkers between patients with schizophrenia (SZ) and healthy controls (HC).
Table 3. Summary of linear regression models on the association between oxidative stress biomarkers and clinical scores in patients.
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Abstract
Introduction

Several studies have described increased oxidative stress parameters in patients with schizophrenia. The objectives of the current study were to identify potential oxidative stress biomarkers in stable patients during first 10 years of schizophrenia and determine if they are associated with specific clinical dimensions.

Material and methods

Seventy-three clinically stable outpatients with schizophrenia and 73 sex and age-matched healthy controls were recruited. Sociodemographic, clinical and biological data were collected at enrollment. Blood biomarkers included homocysteine, the percentage of hemolysis, lipid peroxidation subproducts, and as an antioxidant biomarker, catalase activity in erythrocytes.

Results

Comparative analyses after controlling for smoking and metabolic syndrome evidenced a significant increase in catalase activity in patients. Also, lower lipid peroxidation levels showed an association with negative symptoms.

Conclusions

In conclusion, compensatory antioxidant mechanisms might be increased in stable patients with schizophrenia at early stages. Furthermore, there may be an inverse relationship between oxidative stress and negative dimension.

Keywords:
Oxidative stress
Lipid peroxidation
Catalase
Negative symptoms
Resumen
Introducción

Diversos estudios han encontrado un aumento de los parámetros de estrés oxidativo en pacientes con esquizofrenia. Los objetivos de este estudio han sido identificar potenciales biomarcadores de estrés oxidativo en pacientes con esquizofrenia estables, durante los primeros 10 años de enfermedad, y determinar si se asocian con dimensiones clínicas específicas.

Material y métodos

Se evaluaron 73 pacientes clínicamente estables y 73 controles sanos pareados por edad y sexo. Se recogieron datos sociodemográficos, clínicos y parámetros biológicos. Los biomarcadores sanguíneos incluyeron homocisteína, porcentaje de hemólisis, subproductos de peroxidación lipídica y, como biomarcador antioxidante, actividad de la catalasa en eritrocitos.

Resultados

Los análisis comparativos tras controlar por tabaquismo y síndrome metabólico evidenciaron un aumento significativo en la actividad de la catalasa en pacientes. Asimismo, niveles inferiores de peroxidación lipídica se asociaron de manera significativa con la sintomatología negativa.

Conclusiones

Como conclusión, los mecanismos compensatorios antioxidantes podrían estar aumentados en pacientes con esquizofrenia estables durante las fases iniciales. Además, podría existir una relación inversa entre el estrés oxidativo y la dimensión negativa.

Palabras clave:
Estrés oxidativo
Peroxidación lipídica
Catalasa
Síntomas negativos

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