Buscar en
Revista Española de Anestesiología y Reanimación (English Edition)
Toda la web
Inicio Revista Española de Anestesiología y Reanimación (English Edition) Airway management of COVID-19 patients: A survey on the experience of 1125 physi...
Journal Information
Vol. 69. Issue 1.
Pages 12-24 (January 2022)
Share
Share
Download PDF
More article options
Visits
90
Vol. 69. Issue 1.
Pages 12-24 (January 2022)
Original article
Full text access
Airway management of COVID-19 patients: A survey on the experience of 1125 physicians in Spain
Manejo de vía aérea en pacientes COVID-19: una encuesta sobre la experiencia de 1125 médicos en España
Visits
...
M. Granell Gila,b, N. Sanchís Lópeza,
Corresponding author
neshkapuntocom@hotmail.com

Corresponding author.
, C. Aldecoa Álvarez de Santulanoc, J.A. de Andrés Ibáñeza,b, P. Monedero Rodríguezd, J. Álvarez Escuderoe, R. Rubini Puigb,f, C.S. Romero Garcíaa, on behalf of the COV2-VIAEREA Network Study Group
a Servicio de Anestesiología, Reanimación y T. Dolor, Consorcio General Universitario de Valencia, Spain
b Facultad de Medicina y Odontología, Universitat de Valencia, Valencia, Spain
c Servicio de Anestesiología, Reanimación y T. Dolor, Hospital Universitario Rio Hortega, Valladolid, Spain
d Unidad de Cuidados Intensivos, Clínica Universitaria de Navarra, Pamplona, Spain
e Servicio de Anestesiología, Reanimación y T. Dolor, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain
f Servicio de Urgencias, Consorcio General Universitario de Valencia, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Tables (7)
Table 1. Survey respondent characteristics.
Table 2. Distribution of anaesthesiologists by Spanish autonomous communities.
Table 3. Airway management preferences.
Table 4. Airway management techniques in COVID-19 patients.
Table 5. COVID-19 infection in emergency physicians vs other specialists.
Table 6. COVID-19 infection in the Emergency area.
Table 7. COVID-19 infection in the emergency room or out-of-hospital setting.
Show moreShow less
Abstract
Background

We explored the experience of clinicians from the Spanish Society of Anesthesiology (SEDAR) in airway management of COVID-19 patients.

Methods

An software-based survey including a 32-item questionnaire was conducted from April 18 to May 17, 2020. Participants who have been involved in tracheal intubations in patients with suspected or confirmed COVID-19 infection were included anonymously after obtaining their informed consent. The primary outcome was the preferred airway device for tracheal intubation. Secondary outcomes included the variations in clinical practice including the preferred video laryngoscope, plans for difficult airway management, and personal protective equipment.

Results

1125 physicians completed the questionnaire with a response rate of 40,9%. Most participants worked in public hospitals and were anesthesiologists.

The preferred device for intubation was the video laryngoscope (5.1/6), with the type of device in decreasing order as follows: Glidescope, C-MAC, Airtraq, McGrath and King Vision. The most frequently used device for intubation was the video laryngoscope (70,5%), using them in descending order as follow: the Airtraq, C-MAC, Glidescope, McGrath and King Vision.

Discomfort of intubating wearing personal protective equipment and the frequency of breaching a security step was statistically significant, increasing the risk of cross infection between patients and healthcare workers. The opinion of senior doctors differed from younger physicians in the type of video-laryngoscope used, the number of experts involved in tracheal intubation and the reason that caused more stress during the airway management.

Conclusions

Most physicians preferred using a video-laryngoscope with remote monitor and disposable Macintosh blade, using the Frova guide.

Keywords:
Airway management
COVID-19
Cross infection
Intubation
Video laryngoscope
Resumen
Antecedentes

Analizamos la experiencia de médicos de la Sociedad Española de Anestesiología (SEDAR) en el manejo de vía aérea de pacientes COVID-19.

Métodos

Se realizó una encuesta que incluía 32 ítems (18 abril-17 mayo de 2020). Participaron de forma anónima tras aceptar el consentimiento informado médicos involucrados en intubaciones traqueales en pacientes COVID-19 confirmados o con sospecha. El resultado principal fue el dispositivo de vía aérea preferido para la intubación traqueal. Los resultados secundarios incluyeron el análisis de la práctica clínica, el videolaringoscopio preferido, manejo de vía aérea difícil y uso de equipo de protección personal.

Resultados

Completaron el cuestionario 1125 médicos (tasa de respuesta del 40,9%) que eran mayoritariamente anestesiólogos y trabajaban en hospitales públicos.

El dispositivo preferido para intubar fue el videolaringoscopio (5.1/6) con el siguiente orden de preferencia: Glidescope, C-MAC, Airtraq, McGrath y King Vision. El dispositivo de intubación más utilizado fue el videolaringoscopio (70,5%) con el siguiente orden decreciente: Airtraq, C-MAC, Glidescope, McGrath y King Vision.

La relación de incomodidad de la intubación con equipo de protección personal y la frecuencia de incumplimiento de un paso de seguridad fue estadísticamente significativa, aumentando el riesgo de infección cruzada. La opinión de los médicos senior difería de los más jóvenes en el videolaringoscopio utilizado, número de expertos involucrados en la intubación traqueal y la razón que provocó más estrés durante el manejo de la vía aérea.

Conclusiones

La mayoría de los médicos prefirieron usar un videolaringoscopio con monitor remoto y hoja Macintosh desechable, usando la guía Frova.

Palabras clave:
Manejo de la vía aérea
COVID-19
Infección cruzada
Intubación
Videolaringoscopio
Full Text
Introduction

Tracheal intubation, tracheostomy, and lung protective mechanical ventilation strategies are core treatments in patients infected with the new coronavirus (Severe Acute Respiratory Syndrome coronavirus-2 [SARS-CoV-2]). High risk patients with some type of comorbidity present an inherent risk of severe hypoxaemia and critical reduction in peripheral oxygen saturation, not to mention the risk of cross infection between patients and healthcare workers. Another important consideration is fear of infection among healthcare workers and the discomfort associated with the use of personal protective equipment (PPE)1.

According to official data from the National Epidemiological Surveillance Network of the Ministry of Health of Spain accessed on 21 May 2020 at 11:00 am, 40,921 cases of COVID-19 had been diagnosed among healthcare workers by 11 May 2020, with 4177 hospital admissions, 310 ICU admissions (1.1%) and 53 deaths (0.1%)2. COVID-19 infection in healthcare workers accounted for 16.3% of the 250,273 COVID-19 cases reported as of 10 May 2020. Several aerosol-generating procedures, including endotracheal intubation, manual ventilation by an assistant, tracheostomy, and non-invasive ventilation have been associated with a high risk of viral transmission3.

Clinicians can also use the latest devices to protect themselves during airway management manoeuvres in COVID-19 patients, such as the aerosol box4.

The Spanish Society of Anaesthesiology and Resuscitation (SEDAR) conducted a survey on airway management in patients with COVID-19.

Material and method

Between 28 April and 17 May 2020, SEDAR conducted a national online survey based on a 32-item questionnaire. The survey was approved by the Clinical Research Ethics Committee (CEIm) of the Consorci Hospital General Universitari de València (registration number CPMP/ICH/135/95, approved on 24 April 2020) and conducted by the Spanish COV2-VIAEREA Network study group. The study was registered at https://clinicaltrials.gov.

The questionnaire was sent to members of SEDAR, the Spanish Society of Intensive and Critical Care Medicine and Coronary Units, the Spanish Society of Emergency Medicine, the Spanish Society of Cardiology, the Spanish Society of Pulmonology and Thoracic Surgery, and the Spanish Society of Internal Medicine who had performed tracheal intubation in patients with suspected or confirmed COVID-19, and who gave their consent to participate (Tables 1 and 2).

Table 1.

Survey respondent characteristics.

Questionnaire items  Number (%) 
Which of the following describes your place of work?
Public hospital  912 (81.1) 
Private hospital  53 (4.7) 
Public-private hospital  95 (8.4) 
Out-of-hospital care  65 (5.8) 
Number of years as a specialist (years), mean (SD)  13 (10) 
In which specialist capacity have you had experience with airway management in COVID-19 patients?
Anaesthesiology  1024 (91.0)* 
Intensive medicine  65 (5.7) 
Emergency medicine and emergencies  32 (2.8) 
Cardiology  1 (0.08) 
Pulmonology  2 (0.1) 
Internal medicine  1 (0.08) 
In your experience, where have you intubated most COVID-19 patients?   
Emergency care/Out-of-hospital emergency  67 (5.9) 
Hospital Emergency Department  77 (6.8) 
Intensive Care Unit/Resuscitation Unit  688 (61.2) 
Urgent surgery operating room  228 (20.3) 
Scheduled surgery operating room  47 (4.2) 
Hospital ward  18 (1.6) 
Have you been infected with the SARS-COVID 2 during your work as a front-line healthcare worker during the COVID-19 pandemic?
Yes, I was diagnosed by PCR or serology  132 (11.7) 
No, my PCR or serology was negative  731 (65.1) 
I have never been tested because I have been asymptomatic  224 (19.9) 
I have never been tested, although I have had symptoms  38 (3.4) 

A total of 2503 SEDAR members were contacted by email and through social networks. The response rate was 40.9%.

Table 2.

Distribution of anaesthesiologists by Spanish autonomous communities.

Autonomous community  Active members of SEDAR (n)  Physicians who responded to the survey (n)  Ratio of questionnaires completed by anaesthesiologists/active members of SEDAR (%) 
Andalusia  453  54  11.9 
Aragon    40  20.3 
La Rioja     
Aragon/La Rioja  192  43  22.3 
Asturias    10   
Cantabria     
Asturias-Cantabria  179  16  8.9 
Balearic Islands  64  12.5 
Canary Islands  166  11  6.6 
Castile-Leon  215  38  17.6 
Castillela Mancha  78  55  70.5 
Catalonia  354  220  62.7 
Madrid  739  297  40.3 
Extremadura  115  14  12.1 
Galicia  277  71  25.6 
Murcia  131  13  9.9 
Valencia  434  134  30.8 
Basque Country    29   
Navarre    17   
Basque-Navarra  245  45  18.3 
Total  3642  1125  28.1 

A prerequisite for inclusion in the survey was access to the online Microsoft Forms platform. Participation was anonymous, voluntary and unpaid. The informed consent form was the first item in the questionnaire.

The primary conclusion was clinician preference for a specific airway device (Table 3), and the most widely-used airway device for intubation in patients with COVID-19 (Table 4).

Table 3.

Airway management preferences.

Questionnaire items  Mean (SD)* 
Do you think any of the following systems/guidelines are useful for reducing the generation and/or diffusion of aerosols?   
Aerosol box with hand holes  3.24 (1.70) 
Face mask seal  4.83 (1.08) 
Negative pressure in the intubation area  4.49 (0.56) 
Avoid manual ventilation  5.21 (0.79) 
Rapid sequence induction  5.51 (0.39) 
Sellick manoeuvre  3.27 (1.69) 
Based on your experience with COVID-19 patients, what is the best intubation device?   
Video laryngoscope  5.10 (0.66) 
Direct laryngoscope  3.35 (1.60) 
McCoy laryngoscope  2.91 (1.44) 
Flexible fibrescope  2.37 (1.49) 
What type of video laryngoscope would you prefer to intubate a COVID-19 patient?   
C-MAC  4.46 (1.57) 
King Vision  3.70 (1.47) 
McGrath  3.80 (1.53) 
Glidescope  4.73 (1.39) 
Airtraq  3.85 (1.69) 
In your opinion, what are the disadvantages of video laryngoscopes?   
Annoying reflections on the video laryngoscope screen  2.72 (1.40) 
Difficulty inserting it into the mouth  3.15 (1.41) 
Need for proximity to the patient's upper airway  3.21 (1.60) 
Difficulty inserting the tube through the vocal cords  3.33 (1.48) 
Lack of practical experience with any of the video laryngoscopes used  3.31 (1.75) 
What type of aids do you usually use to facilitate intubation?   
Frova introducer  4.88 (1.14) 
Eschmann stylet  3.66 (1.74) 
Flexible stylet in the orotracheal tube  4.27 (1.51) 
Fibrescope  4.27(1.51) 
VAMA cannula  2.96 (1.66) 
In patients with predicted or known difficult airway, how do you prefer to intubate?   
Flexible fibrescope  3.95 (1.78) 
Video laryngoscope  5.34 (0.56) 
Direct laryngoscope  2.54 (1.46) 
McCoy laryngoscope  2.45 (1.37) 
Laryngeal mask airway  2.51 (1.45) 
Tracheostomy  2.15(1.43) 
In patients with unexpected or unknown difficult airway, how do you prefer to intubate?   
Flexible fibrescope  2.97 (1.67) 
Video laryngoscope  5.55 (0.34) 
Direct laryngoscope  3.0 (1.59) 
McCoy laryngoscope  2.78 (1.48) 
Laryngeal mask airway  3.23 (1.65) 
In COVID 19-positive postoperative patients who require subsequent admission to Resuscitation/ICU, where do you prefer to extubate the patient in order to minimize the risk of contagion?   
I extubate all patients in the post-anaesthesia care unt/ICU  3.43 (1.85) 
I extubate all patients in the operating room  3.70 (1.69) 
I extubate all patients in the operating room if they are stable and postoperative ventilation is not anticipated.  5.25 (0.34) 
In intubated COVID-19 patients requiring a tracheostomy, which of the following do you believe to be true:   
It is better to perform conventional open tracheostomy  3.74 (1.74) 
It is better to perform percutaneous tracheostomy  4.07 (1.65) 
Fibroscopy can be used to guide opening and/or optimal puncture site in any of the foregoing techniques  3.53 (1.81) 
Apnoea must be induced or the ventilator put on stand-by for as long as possible to avoid or minimize air leaks  4.64 (1.11) 
Which of the following statements related to intubation techniques and equipment in COVID-19 patients do you consider important?   
Reuse of contaminated material (e.g. reusable video laryngoscope) is a concern for staff and patients, even if they are cleaned and disinfected  4.66 (1.53) 
Transporting airway equipment/devices between areas with COVID-19 patients and other areas without COVID-19 patients is a concern for both patients and staff  5.22 (0.74) 
Intubation of critical or urgent COVID-19 patients is a rushed procedure that increases the risk of contagion among staff  5.11 (0.87) 
It is far more difficult and uncomfortable to perform airway management procedures when wearing personal protective equipment (PPE)  5.33 (0.62) 
How would you rate wearing PPE while intubating a COVID-19 patient, with 1 being slightly uncomfortable and 10 very uncomfortable?  8.11 (1.55) 
How much more difficult did wearing the PPE needed to intubate COVID-19 patients make the procedure, with 1 being only slightly more difficult and 10 being much more difficult?  6.81 (2.14) 
*

Mean (standard deviation) of the 6-point Likert scale (from 1 = strongly disagree to 6 = strongly agree).

Table 4.

Airway management techniques in COVID-19 patients.

Questionnaire items  Number (%)  P value* 
Of the devices available in your place of work, which have you used most frequently to intubate COVID-19 patients?    NS 
Video laryngoscope  793 (70.5)   
Direct laryngoscope  320 (28.4)   
McCoy laryngoscope  10 (0.9)   
Flexible fibrescope  2 (0.2)   
Of the video laryngoscopes available in your place of work, which have you used most frequently to intubate COVID-19 patients?    <0.0001 
C-MAC  248 (22.0)   
King Vision  82 (7.3)   
McGrath  141 (12.5)   
Glidescope  231 (20.5)   
Airtraq  292 (25.9)   
I did not have a video laryngoscope  66 (5.9)   
I prefer to use direct laryngoscopy because I am more experienced and feel more confident with this technique  65 (5.8)   
Which type of video laryngoscope blade do you prefer to use in COVID-19 patients?    NS 
Reusable  153 (13.6)   
Disposable (single-use)  972 (86.4)   
Which type of video laryngoscope blade have you used most frequently in COVID-19 patients?    NS 
Reusable  457 (40.6)   
Disposable (single-use)  668 (59.4)   
Which type of video laryngoscope blade do you prefer to use?    NS 
Channelled  431 (38.3)   
Non-channelled  301 (26.8)   
Indifferent  287 (25.5)   
I have no experience  106 (9.4)   
Which type of video laryngoscope blade do you prefer to use?    NS 
Macintosh blade  533 (47.4)   
Hypercurved blade  320 (28.4)   
Indifferent  170 (15.1)   
I have no experience  102 (9.1)   
Which type of video laryngoscope screen do you prefer to use in COVID-19 patients?    NS 
In-built screen  236 (21.0)   
Separate/distant screen  695 (61.8)   
Indifferent  126 (11.2)   
I have no experience  68 (6.0)   
Do you pre-oxygenate prior to intubation/tracheostomy?     
Yes, for at least 5 min  350 (31.1)   
Yes, for 3−5 min  484 (43.0)   
Yes, for at least 1 min  117 (10.4)   
No, no delay was possible due to the patient’s status  137 (12.2)   
No, due to the stress of the situation and the context  37 (3.3)   
When needing to intubate a patient with suspected or confirmed COVID-19, how many clinicians with experience in airway management participated, including yourself?    <0.0001 
328 (29.2)   
729 (64.8)   
3 or more  68 (6.0)   
Despite your familiarity with the steps and measures needed to minimize risks when securing the airway in a COVID-19 patient, do you think you have ever forgotten a particular safety step due to the stress of the situation?    NS 
Never  156 (13.9)   
Sometimes  728 (64.7)**   
Nearly always  226 (20.1)**   
Always  15 (0.3)   
What caused you most stress when securing the airway in a COVID-19 positive?    <0.0001 
Failed intubation and rapid deterioration of the patient  551 (49.0)   
Encountering an unforeseen difficult airway  355 (31.6)   
Fear of infection  219 (19.4)   
*

Comparison with the variable «seniority» (years of experience) as a continuous variable using one-way ANOVA.

**

P < 0.0001.

Secondary conclusions were clinical practice variables (use of pre-oxygenation), the use of video laryngoscopes, difficult airway approach, and the use of safety methods/procedures to prevent the risk of cross-infection between patients and healthcare workers (Tables 3–7).

Table 5.

COVID-19 infection in emergency physicians vs other specialists.

  n = 32  n = 1093  p-Value 
  Emergency Physicians  All physicians (except emergency physicians)   
Yes, positive PCR  15.6% [3.28] (5)  11.7% [10.14] (131)  NS 
No, negative PCR  50% [33.67] (16)  65.1% [62.68] (731)  NS 
Asymptomatic and no test  25% [10.40] (8)  19.9% [17.22] (223)  NS 
Symptomatic and no test  9.4% [0.20] (3)  3.4% [2.4] (38)  NS 

[95% confidence interval] (number).

Chi square test for independent samples.

Table 6.

COVID-19 infection in the Emergency area.

  n = 32  n = 77  p-Value 
  Emergency Physicians  Tracheal intubation in hospital Emergency department   
Yes, positive PCR  15.6% [3.28] (5)  6.5% [1.12] (5)  0.05 
No, negative PCR  50% [33.67] (16)  67.5% [57.78] (52)  NS 
Asymptomatic and no test  25% [10.40] (8)  20% [12.30] (16)  NS 
Symptomatic and no test  9.4% [0.20] (3)  5.2% [0.10] (4)  NS 

[95% confidence interval] (number).

Chi square test for independent samples.

Table 7.

COVID-19 infection in the emergency room or out-of-hospital setting.

  n = 57  n = 77  p-Value 
  Ambulance service  Tracheal intubation in the hospital emergency room   
Yes, positive PCR  17.5% [8.27] (10)  6.5% [1.12] (5)  0.05 
No, negative PCR  59.6% [47.72] (34)  67.5% [57.78] (52)  ns 
Asymptomatic and no test  19.3% [9.30] (11)  20% [12.30] (16)  ns 
Symptomatic and no test  3.5% [0.8] (2)  5.2% [0.10] (4)  ns 

[95% confidence interval] (number).

Chi square test for independent samples.

The first draft of the questionnaire was developed and reviewed by 4 experienced anaesthesiologists. The questionnaire was tested and validated by 9 independent physicians with at least 5 years of experience, including 2 anaesthesiologists, 2 intensivists, 2 emergency care specialists, a cardiologist, a pulmonologist, and a member of the ambulance service. Most items were single-answer questions, but 6-point Likert scale questions were also included (1 = totally disagree, 6 = totally agree). The survey was conducted on the Microsoft Forms Office 365 platform (Microsoft, Redmond, Washington, USA).

Answers to all questions had to be included in the final analysis. A link to the survey was posted on various social media platforms, including LinkedIn, Facebook, and Twitter. Participants were recruited using the snowball sampling technique.

Sample size calculation

Selection bias was reduced by posting the survey mainly on social networks and collecting between 800 and 1300 completed questionnaires from at least 10 autonomous communities. This number was estimated on the basis of data from the Spanish Society of Anaesthesiology, and corresponded to 10% of physicians in each autonomous community.

Statistical analysis

Categorical variables are expressed as frequencies and percentages, and quantitative variables as mean and standard deviation (SD) or median and range. One-way analysis of variance (ANOVA) and the Tukey multiple comparison test were used to analyse the Likert categories «I never forget» and «I nearly always forget» in the Forgetting safety steps variable, and “at times” and “nearly always” for the PPE discomfort variable. As all the points on the ordinal scale were equidistant, they were analysed as a continuous variable according to Long and Freese5, who stated that an ordinal variable can be treated as though it had linear effects; doing so may be sufficiently offset any disadvantage. The variable “seniority” referred to years of experience, and was evaluated as a continuous variable for the comparison of “preferred video laryngoscope”, “most widely-used device”, “preferred blade”, “most widely-used blade” and “number of experts during intubation”. The variables “number of intubations performed” and “infection” were analysed with the Kruskal–Wallis test. Statistical significance was set at p < 0.05. The sample size was calculated for a confidence interval of 95% and a margin of error of 3%, for which a total of 1068 questionnaire respondents were needed (α = 0.05 and β = 0.80). The statistical program R (version 3.5.2) was used for data analysis6.

Results

A total of 1125 physicians with a mean age (SD) of 42 (10) years and a mean of 13 (10) years’ experience in their specialties completed the questionnaire. They had performed 6,816 orotracheal intubations, with a mean of 6 procedures per physician (Table 1).

As shown in Table 1, most respondents worked in public hospitals (81.1%) and were anaesthesiologists (91.0%); 5.8% were specialists in Intensive Care Medicine and 2.8% were specialists in Emergency Medicine.

More than 60% of COVID-19 patients were intubated in the ICU, 20.3% in operating rooms when urgent surgery was required, and 6.8% in the hospital emergency department. In total, 74.1% of participants pre-oxygenated the patient for 3−5 min or more than 5 min prior to intubation compared with 10.4% who performed this manoeuvre for less than 1 min. Pre-oxygenation was not performed by 15.5% of participants due to the critical condition of the patient or a stressful personal situation (Table 4).

A total of 1125 physicians completed the entire questionnaire, with a response rate of 40.9% among the anaesthesiologists contacted (1,024 anaesthesiologists/2,503 SEDAR members contacted by email and social media). In total, 28.1% of all active SEDAR members took part in the survey, and participation rates exceeded 10% in most autonomous communities (14/17). Therefore, we believe the survey is representative of these communities and of Spain as a whole (Table 2). The autonomous communities with the highest number of participants were those with the highest incidence of COVID-19, particularly Madrid, Catalonia and Valencia.

Regarding preferences in airway management (Table 3), the preferred device for intubation was the video laryngoscope (5.10/6), followed by (in descending order of preference): Glidescope, C-MAC, Airtraq, McGrath and King Vision.

The most widely-used video laryngoscopes were the following, in descending order: Airtraq, C-MAC, Glidescope, McGrath and King Vision. The Airtraq was the most widely-used video laryngoscope in the ambulance service, in the ICU, and in patients undergoing urgent surgical procedures, while the C-MAC was the video laryngoscope most commonly used during scheduled surgery and on the hospital ward (Fig. 1).

Figure 1.

Use of different types of video laryngoscope according to where intubation was performed (out-of-hospital emergency; in-hospital emergency room; ICU: intensive care or resuscitation unit; emergency surgery operating rooms; scheduled surgery operating rooms; hospital ward).

(0.19MB).

Regarding video laryngoscope blades (Table 4), most respondents preferred video laryngoscopes with a disposable blade (86.4%), followed by curved Macintosh blade (47.4%) and channelled blades (38.3%), and most respondents preferred using a videolaryngoscope with a separate screen (61.8%). In terms of airway management devices, most respondents used disposable video laryngoscopes (70.5%) and blades (59.4%).

The video laryngoscope was the preferred intubation device in cases of suspected or unanticipated difficult airway. The Frova introducer, the flexible stylet in the orotracheal tube, and the fibreoptic bronchoscope were the preferred methods of facilitating tracheal intubation (Table 3).

A total of 131 physicians (11.6%) did not use any type of video laryngoscope (Table 4), either because they were unavailable or due to personal preference for conventional laryngoscopy. Ambulance service personnel used direct laryngoscopy in 87.5% of cases.

In 70.8% of cases, 2 or more physicians participated in tracheal intubation of COVID-19 patients. When asked to evaluate the impact of stress associated with the clinical management of COVID-19 patients, 969 physicians (86.1%) admitted they "forget one or more safety steps". For respondents, intubation failure and deterioration of the patient's status are the most stressful circumstance (49%), followed by a difficult airway (31.6%) and fear of contagion (19.4%). The variable Seniority (years of experience) correlated significantly with the type of video laryngoscope most widely used, the number of expert physicians who participated in intubation, and the most stressful circumstance (Table 3). Respondents considered PPE to be very uncomfortable and a significant hindrance for intubation. Furthermore, 64.7% of respondents stated that they were Sometimes and 20.1% that they were almost always unable to comply with safety measures due to the discomfort of wearing PPE. This difference was statistically significant (p < 0.0001).

Regarding extubation, respondents preferred to intubate in the operating room if the patient was stable and there was no need for postoperative mechanical ventilation.

In terms of tracheostomy, respondents showed a similar preference for percutaneous or open tracheostomy. They also considered fibreoptic guidance to be relatively acceptable during these techniques (3.5/6), and considered it very important to induce apnoea during the period of greatest risk of air leaks (4.6/6).

Regarding the risk of cross infection between patients and healthcare workers (Table 1), 862 physicians (76.6%) had undergone PCR testing for SARS-CoV-2 infection, which was positive in 131 cases (11.6%). Ambulance service personnel intubating patients with COVID-19 (Fig. 2) presented a statistically higher incidence of positive PCR; however, the number of intubations performed was not correlated to the frequency of COVID-19 infection (Fig. 3).

Figure 2.

SARS-CoV-2 infection status and place where intubation was performed (out-of-hospital; in-hospital emergency room; ICU: intensive care or resuscitation unit; urgent surgery operating rooms; scheduled surgery operating rooms; hospital ward).

(0.19MB).
Figure 3.

Number of intubations performed and frequency of SARS-CoV-2 infection in healthcare workers.

(0.17MB).

Regarding intubation in the hospital emergency department (ED) (n = 77), 4 tracheal intubations were performed per specialist (4 [3]) (Tables 5–7). Most (70%) tracheal intubations were performed by anaesthesiologists, and 30% by emergency specialists. Pre-oxygenation was applied for more than 3 min by 78% of respondents, and for less than 1 min by 9%. Pre-oxygenation was impossible in 13% of cases, due either to the patient’s status or to stressful circumstances. Video laryngoscopy was used in 61% of intubations, and the most widely-used video laryngoscope was the C-MAC (19.5%). Disposable blades were preferred (79.2%) and most widely-used (63.6%). Two physicians were present in 64.9% of intubations and 55.8% had Sometimes forgotten a safety step. According to most respondents, the most stressful situations were fear of intubation failure or deterioration of patient status.

Regarding the Ambulance/Outpatient Emergency Service area (n = 67), 3 tracheal intubations were performed per specialist (3 [2]); 97% of these respondents worked exclusively in out-of-hospital emergencies. Pre-oxygenation was applied for more than 3 min by 47% of respondents, and for less than 1 min by 12%. Pre-oxygenation was impossible in 41% of cases. Direct laryngoscopy was used in 90% of intubations. In 69% of cases, a video laryngoscope was not available. Disposable blades were preferred (84%) and most widely-used (51%). Only 1 physician was involved in 50% of intubations. Half of the respondents (51%) had sometimes forgotten a safety step, and 44% claimed that Fear of contagion was the most stressful situation. The incidence of COVID-19 infection was statistically higher among emergency medicine specialists (15.6%) and doctors working in the ambulance service (17.5%) compared to specialists who intubated patients in the hospital emergency area (6.5%), as shown in Tables 5–7.

Discussion

In a systematic review of aerosol-generating procedures and the risk of transmission of acute respiratory infections, tracheal intubation was identified as the most high-risk technique7. Tracheal intubation also exposes healthcare workers to a high viral load and, therefore, more serious infection8. The World Health Organization has defined a series of aerosol-generating medical procedures9, but some authors consider this list to be outdated in the context of COVID-19. Many of the procedures defined as aerosol generating may pose a risk because they generate coughing, and bronchoscopy and physiotherapy would probably fit this description10.

During an epidemic, each patient can be considered a potential source of infection, and all airway/respiratory system interventions may need to be treated as high-risk11. In our survey, 862 of respondents who participated in airway management procedures underwent diagnostic tests (76.6%), which were negative in 65.1% of cases. In our survey, the infection rate found among professionals involved in intubation and airway management was 11.6%, which is in line with previous studies. However, at the time of the survey, COVID-19 screening of healthcare workers was basically limited to symptomatic individuals, probably because the healthcare service lacked the capacity to test all physicians involved in intubating COVID-19 patients. This means that the incidence observed in our survey may be underestimated, as many asymptomatic physicians were not evaluated.

The infection rate was higher among ambulance service personnel. Out-of-hospital airway management differed from in-hospital airway management, but we cannot confirm whether this is one of the reasons for the higher incidence of COVID-19 cross-infection among ambulance patients and physicians. However, no significant relationship was found between the number of intubations performed and the probability of being infected by SARS-CoV-2.

In terms of measures to prevent aerosol formation, respondents highly recommended performing rapid sequence induction, avoiding manual ventilation prior to intubation, and maintaining a good face mask seal. This is in line with other studies that also recommend avoiding cough-generating manoeuvres12–14. The methods least recommended by respondents were the Sellick manoeuvre, probably because it can hinder tracheal intubation15,16, and the use of aerosol boxes - probably because placing the device prolongs intubation, and there is a risk of breaking the protective seal.

The video laryngoscope was the preferred and most widely-used intubation device in COVID-19 patients, as reported in other studies17. This was also the most highly recommended device in previous studies in airway management in COVID-19 patients and in SEDAR protocols, since in other clinical situations it has been shown to improve visualisation of the glottis, reduce the time to successful intubation, increase the first attempt intubation success rate, increase the overall intubation success rate, reduce the need for force, and reduce intubation-related complications11,12. According to some authors, proficiency with videolaryngoscope is unlikely to be achieved if their use remains limited to predicted or unpredicted difficult intubation, and acquiring expertise in videolaryngoscopy will require frequent rather than occasional use of the device, both in operating rooms and in ICUs12. Although the availability of all types of video laryngoscopes was not specified in the questionnaire, the 3 most widely-used types of video laryngoscopes were Airtraq, C-MAC, and Glidescope. McGrath and King Vision were the least used, and a statistically significant difference was observed between preferred devices among senior and junior operators.

The 3 preferred video laryngoscopes were Glidescope, C-MAC, and Airtraq. Respondents also showed a greater preference for videolaryngoscopes with a separate screen, which enables the operator to stand further from the airway11,18.

The disposable video laryngoscope blade was both the most preferred and the most widely-used blade, although the percentage of use was lower than that of preference, probably due to the unavailability of this type of blade in some hospitals. This type of disposable blade has also been highly recommended by other authors11,12. Regarding the curvature of the blade used, the Macintosh curved video laryngoscope blade was preferred over the hyper-curved blade. In line with other studies, the most widely recommended intubation aid was the Frova introducer19. The technique of combining a video laryngoscope with an introducer/bougie has also been suggested by other authors2, and is associated with an intubation success rate of close to 98%20. Respondents were in favour of using a flexible stylet inside the orotracheal tube. Other authors have reported that the use of the flexible stylet inside the tracheal tube at an angle of 60° gave faster tracheal intubation21. The least used device was the fibreoptic bronchoscope, which is also consistent with recommendations against using this device due to the risk of generating aerosols14.

The choice of intubation device did not differ significantly between older and younger operators, showing that more experienced physicians are also interested in using the latest optical devices. According to 70.8% of respondents, 2 or more clinicians are usually involved in intubating patients during the COVID-19 pandemic. According to other authors17, the presence of 2 or more clinicians during tracheal intubation is safer for both the patient and the medical team.

An interesting finding of our survey was the correlation between the use of PPE and non-compliance with safety measures. Respondents considered PPE to be very uncomfortable, and tracheal intubation was more difficult when wearing PPE. Some authors have reported difficulties in achieving PPE compliance and in training healthcare workers to correctly prepare and don PPE22. According to other studies, first-attempt intubation success rate with direct laryngoscopy or video laryngoscope is 96% without PPE and 58% when PPE is used20.

In our opinion, based mainly on the results obtained from this survey of Spanish doctors involved in the intubation of COVID-19 patients during the first wave of the pandemic in Spain, pre-oxygenation manoeuvres and aerosol generation reduction strategies, such as rapid sequence induction, avoiding manual ventilation prior to intubation, and proper face mask sealing, are extremely important. We also believe it is advisable to use a video laryngoscope with a disposable blade and separate screen, and to facilitate intubation by using the Frova introducer or flexible stylet. Finally, it is far more uncomfortable and difficult to perform tracheal intubation while wearing PPE.

This study has some limitations. As the survey was promoted by SEDAR, most respondents were anaesthesiologists who are usually experts in airway management using different advanced airway devices. Several patients intubated on an outpatient basis had a suspected diagnosis of SARS-CoV-2 infection, but the definitive diagnosis was made later. In the questionnaire, the item enquiring about preference for disposable over reusable video laryngoscopy blades did not include “I have no experience”.

Conclusions

Spanish physicians involved in orotracheal intubation in patients with COVID-19 consider preoxygenation, aerosol generation reduction manoeuvres such as rapid sequence induction, avoidance of manual ventilation before intubation, and good face mask sealing to be essential for safe intubation. Respondents also believed the video laryngoscope with a separate screen and disposable blade, and the Frova introducer or flexible stylet to be very useful and safe tools. Most respondents thought that intubation should be performed by at least 2 experts wearing PPE, following safety standards. However, there is a certain discrepancy between respondents’ preference for disposable videolaryngoscope blades (86.4%) and their actual use (59.4%), which could well be due to the limited availability of these devices during the first wave of the pandemic in Spain.

Finally, the discomfort of performing intubation while wearing PPE was a common cause of non-compliance with some safety steps, and could increase the risk of cross infection between patients and healthcare workers. Therefore, in our opinion, urgent measures are needed to improve these weak points and optimise the protection of at-risk healthcare workers.

We believe further research is required to determine why the incidence of COVID-19 infection is higher among emergency doctors treating patients with suspected or confirmed COVID-19 infection who work under stress with limited airway management equipment. The infection rate among healthcare workers may be underestimated, since many asymptomatic physicians working in the hospital or ambulance service were not systematically tested for COVID-19 infection.

Conflict of interests

The authors have no conflict of interest to declare.

Appendix A
COV2-VIAEREA Network Study Group

Ferrer Gómez C, Durá Navarro R, Moliner Velázquez S, Bosch Velázquez M, Casanova Montes I, Muñoz Devesa L, Vergara Sánchez A, López Palanca S, Morales Sarabia J, Errando Oyonarte C, Vicente Fernández P, Peiró Alós CM, Briones Través A, Lacoste O y Aisa Gasca I (Consorci Hospital General Universitari de València, València); Esturi Navarro R y Sánchez García F (Hospital Universitario de la Ribera, València); Beltrán Alandí RA (Hospital de Lliria, Valéncia); Lorente García PJ (Hospital General Universitari de Castelló, Castelló); Serrano Alonso J (Hospital Vithas Rey Don Jaime, Castelló); Argente Navarro P, Vicente Guillén R, Pajares Moncho A, Aparicio Chagoyen R, Ferrer Colomer A, Carmona García P, y Pons Frigola A (Hospital Universitari i Politècnic La Fe, València); Parra González MJ, Tornero Tornero C, y Casterá Brugada MA (Hospital Clínic Universitari de València, Valéncia); Bueno Latorre N y Herrera de Pablo P (SAMU Valéncia); Cruz Pardos P, Portas González M, de Miguel Guijarro A, Barrio Saiz E, Vera Blas M, Rubio Murias P, y González Carranza JE (Hospital General Universitario Gregorio Marañón, Madrid); González Perrino C (Hospital Clínico San Carlos, Madrid); Valencia Orgaz O, García Gutiérrez AF, Adriana Calderón Z, y Real Navacerrada MI(Hospital Universitario 12 de Octubre, Madrid); Garrido Ortega P, Caldera Álvarez MV, Menéndez Gallego JA, Uña Orejón R, y Ruiz López JJ (Hospital Universitario La Paz, Madrid); Planas Roca A y Ramasco Rueda F (Hospital Universitario de la Princesa, Madrid); Abad Gurumeta A (Hospital Infanta Leonor, Madrid); Canales Corcho I, Horrillo García C, y Serrano Moraza A (SUMMA, Madrid); Almagro Vidal I (Hospital Gómez Ulla, Madrid); Valero Castell R, Ubré Lorenzo M, Bergé Ramos R, Belda Tortosa I, Perdomo Linares JM, Jacas A, y Angelès Fité GS (Hospital Clínic, Barcelona); Fábregas Blanco I y Vitale S (Consorci Sanitari del Maresme, Barcelona); Caldentey Sierra J (Hospital Universitari Vall d’Hebron, Barcelona); Roig Pineda R y Tolós París R (Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona); Bermejo S y Gallart Gallego Ll (Hospital del Mar-Parc de Salut Mar, Barcelona); Marín Posada PA, Miró Bernié G, y Vives Santacana M (Hospital Universitari de Girona Doctor Josep Trueta, Girona); Sánchez López A, López-Torres López J, y de Capadocia Rosell J (Complejo Hospitalario Universitario de Albacete, Albacete); Sánchez Andrés A y Gallego Ligorit L (Hospital Universitario Miguel Servet, Zaragoza); Pastor Marcos D (Hospital Universitario Lucus Augusti, Lugo); Callado Moro FJ (Hospital Universitario de Burgos, Burgos); Hernández Martínez A (Grupo Policlínica, Ibiza); Mora Fernández C y Brogi L (Hospital Universitari Son Espases, Palma); Malo Manso A (Hospital Universitario Virgen de la Victoria, Málaga); González-Delgado A (Clínica Universidad de Navarra, Pamplona); Pernia Romero A y Torres Morera LM (Hospital Universitario Puerta del Mar, Cádiz); Cortiñas Díaz J, del Río Fernández S, y Prada Hervella G (Hospital Clínico Universitario de Santiago, Santiago de Compostela), España; and Echeverría J (University Hospitals Coventry and Warwickshire NHS Trust, Coventry), UK.

References
[1]
G. Kovacs, N. Sowers, S. Campbell, J. French, P. Atkinson.
Just the facts: airway management during the coronavirus disease 2019 (COVID-19) pandemic.
[2]
Red Nacional de Vigilancia Epidemiológica, RENAVE (National Epidemiological Surveillance Network). National Center of Epidemiology. Ministry of Health. Informe sobre la situación de COVID-19 en personal sanitario en España. Fecha del informe 21-05-2020. [Accessed 3 July 2020]. Available from: https://cnecovid.isciii.es/.
[3]
Respiratory care committee of Chinese Thoracic Society.
Expert consensus on preventing nosocomial transmission during respiratory care for critically ill patients infected by 2019 novel coronavirus pneumonia.
Zhonghua Jie He He Hu Xi Za Zhi, 17 (2020), pp. E020
[4]
J.L. Begley, K.E. Lavery, C.P. Nickson, D.J. Brewster.
The aerosol box for intubation in coronavirus disease 2019 patients: an in-situ simulation crossover study.
[5]
J.S. Long, J. Freese.
Regression Models for Categorical Dependent Variables Using Stata.
second edition, Stata Press, (2006),
[6]
R Core Team.
R: A language and environment for statistical computing.
[7]
K. Tran, K. Cimon, M. Severn, C.L. Pessoa-Silva, J. Conly.
Aerosol-generating procedures and risk of transmission of acute respiratory infections: a systematic review.
Canadian Agency for Drugs and Technologies in Health, (2011),
[8]
Z. Wu, J.M. McGoogan.
Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a Report of 72 314 cases from the Chinese Center for Disease Control and Prevention.
[9]
World Health Organization.
WHO guidelines: infection prevention and control of epidemic- and pandemic-prone acute respiratory infections in health care.
[10]
J. Brown, C. Pope.
Personal protective equipment and possible routes of airborne spread during the COVID-19 pandemic.
Anaesthesia, 26 (2020),
[11]
T.M. Cook, K. El-Boghdadly, B. McGuire, A.F. McNarry, A. Patel, A. Higgs.
Consensus guidelines for managing the airway in patients with COVID-19: Guidelines from the Difficult Airway Society, the Association of Anaesthetists the Intensive Care Society, the Faculty of Intensive Care Medicine and the Royal College of Anaesthetists.
Anaesthesia, 75 (2020), pp. 785-799
[12]
A. De Jong, E. Pardo, A. Rolle, S. Bodin-Lario, Y. Pouzeratte, S. Jaber.
Airway management for COVID-19: a move towards universal videolaryngoscope?.
Lancet Respir Med, 8 (2020), pp. 555
[13]
R.S. Wax, M.D. Christian.
Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients.
Can J Anaesth, 67 (2020), pp. 568-576
[14]
K.M. Caputo, R. Byrick, M.G. Chapman, B.J. Orser, B.A. Orser.
Intubation of SARS patients: infection and perspectives of healthcare workers.
Can J Anaesth, 53 (2006), pp. 122-129
[15]
A. Birenbaum, D. Hajage, S. Roche, A. Ntouba, M. Eurin, P. Cuvillon, et al.
Effect of cricoid pressure compared with a sham procedure in the rapid sequence induction of anesthesia: the IRIS randomized clinical trial.
JAMA Surg, 154 (2019), pp. 9-17
[16]
T.M. Cook.
The cricoid debate — balancing risks and benefits.
Anaesthesia, 71 (2016), pp. 721-722
[17]
W. Yao, T. Wang, B. Jiang, F. Gao, L. Wang, H. Zheng, et al.
Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations.
Br J Anaesth, 125 (2020), pp. e28-e37
[18]
M. Şentürk, M.R. El Tahan, L.L. Szegedi, N. Marczin, W. Karzai, B. Shelley, et al.
Thoracic anesthesia of patients with suspected or confirmed 2019 novel coronavirus infection: preliminary recommendations for airway management by the European association of cardiothoracic anaesthesiology thoracic subspecialty committee.
J Cardiothorac Vasc Anesth, (2020),
[19]
B.E. Driver, M.E. Prekker, L.R. Klein, R.F. Reardon, J.R. Mier, E.T. Fagerstrom, et al.
Effect of use of a bougie vs endotracheal tube and stylet on first-attempt intubation success among patients with difficult airways undergoing emergency intubation: a randomized clinical trial.
JAMA, 319 (2018), pp. 2179-2189
[20]
R. Scott Taylor, M. Pitzer, G. Goldman, A. Czysz, T. Simunich, J. Ashurst.
Comparison of intubation devices in level C personal protective equipment: a cadaveric study.
Am J Emerg Med, 36 (2018), pp. 922-925
[21]
J. Lee, J.Y. Kim, S.Y. Kang, H.J. Kwak, D. Lee, S.Y. Lee.
Stylet angulation for routine endotracheal intubation with McGrath videolaryngoscope.
Medicine (Baltimore), 96 (2017), pp. e6152
[22]
P.M. Odor, M. Neun, S. Bampoe, S. Clark, D. Heaton, E.M. Hoogenboom, et al.
Anaesthesia and COVID-19: infection control.
Br J Anaesth, 125 (2020), pp. 16-24

The names of the components of the COV2-VIAEREA Network Study Group are listed in the Appendix A.

Please cite this article as: Granell Gil M, Sanchís López N, Aldecoa Álvarez de Santulano C, de Andrés Ibáñez JA, Monedero Rodríguez P, Álvarez Escudero J, et al. Manejo de vía aérea en pacientes COVID-19: una encuesta sobre la experiencia de 1125 médicos en España. Rev Esp Anestesiol Reanim. 2022;69:12–24.

Copyright © 2021. Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos