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Original Investigation
DOI: 10.1016/j.rcreue.2021.06.001
Prevalence of latent tuberculosis determined using the Purified Protein Derivative (PPD) test in adult patients with rheumatoid arthritis receiving biotechnological therapy
Prevalencia de tuberculosis latente determinada mediante la prueba de derivado proteico purificado (PPD) en una población de pacientes adultos con artritis reumatoide llevados a terapia biotecnológica
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Claudia Moraa,
Corresponding author
claudia.mora@unisabana.edu.co

Corresponding author.
, Alirio Rodrigo Bastidas Goyesa,b, Jonnatan Patiñoc, Juan David Verac, Adriana Beltránd, Catalina Mutisc, Oscar Ricardo Barónc
a Department of Internal Medicine, Facultad de Medicina, Universidad de La Sabana, Bogota, Colombia
b Research Department, Faculty of Medicine, Universidad de La Sabana, Bogotá, Colombia
c Internal Medicine Residence, Universidad de La Sabana, Bogota, Colombia
d Research Department, Central Military Hospital, Bogota, Colombia
Received 06 May 2020. Accepted 27 August 2020
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Table 1. General characteristics of the total population, subjects with latent tuberculosis and without latent tuberculosis.
Table 2. Characteristics of clinimetry and paraclinical tests in general population, subjects with latent tuberculosis and without latent tuberculosis.
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Abstract
Introduction

Although tuberculosis (TB) is endemic in Colombia, with a prevalence of 26 cases per million, there are no recent and clear data regarding the prevalence of latent tuberculosis (LBT) in the population with rheumatoid arthritis (RA), candidates for biotechnological therapy.

Methodology

A cross-sectional study with an analytical component to determine the prevalence of LBT in patients with RA who are candidates for biotechnological therapy.

Results

The prevalence of LBT in RA patients who are candidates for biotechnological therapy is high, 18.3% (95% CI: 14.7–21.9). In the exploratory analysis, a relationship between LBT and male gender was found (P < .001), as well as abnormal findings on chest radiography (P = .039), and smoking (P = .028).

Conclusion

The prevalence of LBT in patients with RA who are candidates for biotechnological therapy is high. Prospective studies are needed to evaluate the incidence of TB in this group of patients and corroborate this association.

Keywords:
Latent tuberculosis
Tuberculosis
Rheumatoid arthritis
Biotechnological therapy
Anti-TNF
Rheumatic diseases
Prevalence
Resumen
Introducción

Colombia es un país endémico para tuberculosis (TB), con una prevalencia de 26 casos por millón. Sin embargo, no se cuenta con datos recientes y claros respecto a la prevalencia de tuberculosis latente (TBL) en la población con artritis reumatoide (AR) candidata a terapia biotecnológica.

Metodología

Estudio de corte transversal con componente analítico para determinar la prevalencia de TBL en pacientes con AR candidatos a terapia biotecnológica.

Resultados

La prevalencia de TBL en pacientes con AR candidatos a terapia biotecnológica es alta: 18,3% (IC 95% 14,7–21,9), y en los cruces exploratorios se encontró una relación de TBL y la variable género masculino (P = <,001), hallazgos anormales en la radiografía de tórax (P =,039) y el tabaquismo (P =,028).

Conclusión

La prevalencia de TBL en paciente con AR candidatos a terapia biotecnológica es alta. Se requieren estudios prospectivos para evaluar la incidencia de TB en este grupo de pacientes y así corroborar su asociación.

Palabras clave:
Tuberculosis latente
Tuberculosis
Artritis reumatoide
Terapia biotecnológica
Anti-TNF
Enfermedad reumática
Prevalencia

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