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Autoimmune manifestations in pediatric patients with human type I T - cell lymphotropic virus (HTLV-1) infection
Manifestaciones autoinmunes en pacientes pediátricos con infección por virus linfotrópico humano de células T tipo I (HTLV-1)
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Laura Isabel Restrepo Figueroaa,
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laurarestrepofigueroa@gmail.com

Corresponding author.
, Ximena Alexandra Basto Escobara, Carlos Andrés García Muñoza, Juan Pablo Malagón Caicedoa, José Danilo Jojoa Ríosb, Juan Pablo Rojas Hernándezc
a Facultad de Medicina, Universidad Libre, Cali, Colombia
b Especialización en Pediatría, Facultad de Medicina, Universidad Libre, Cali, Colombia
c Doctorado en Salud, Universidad del Valle. Fundación Clínica Infantil Club Noel. Grupo de investigación GRINPED, Postgrado de Pediatría, Universidad Libre, Cali, Colombia
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Received 11 March 2020. Accepted 17 June 2020
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Table 1. Diseases associated with HTLV-1.
Table 2. Description of clinical cases.
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Abstract

HTLV-1 is a retrovirus that has an impact on human health due to its T-lymphocyte tropism. It occurs worldwide, but is more prevalent in tropical regions. Although most infected individuals will remain asymptomatic, the infection may manifest with complications such as uveitis, myelopathy, and leukemia, among others. The diagnosis is achieved by the detection of anti-HTLV antibodies and a confirmatory test (Western Blot or proviral load). Although there is no specific treatment, medical treatments are aimed towards the management of secondary diseases. Three cases are described of pediatric patients diagnosed with HTLV-1 infection and associated autoimmune manifestations.

Keywords:
Human T-lymphotropic virus 1
Retrovirus
Autoimmune
Uveitis
Thrombocytopenia
Crohn’s disease
Resumen

El HTLV-1 es un retrovirus que causa impacto en la salud del ser humano, debido al tropismo para infectar a linfocitos T. Está distribuido mundialmente, pero es más prevalente en regiones tropicales. La mayoría de las personas afectadas permanecen asintomáticas, sin embargo, al manifestarse puede causar complicaciones como uveítis, mielopatía, leucemia, entre otras. Su diagnóstico se hace mediante la determinación de anticuerpos anti-HTLV y prueba confirmatoria (Western Blot o carga proviral). No tiene tratamiento específico, las medidas están dirigidas a la prevención y el manejo de las patologías secundarias. Se describen tres pacientes en edad pediátrica con diagnóstico de infección por HTLV-1 y manifestaciones autoinmunes.

Palabras clave:
Virus linfotrópico humano de células T tipo 1
Retrovirus
Autoinmune
Uveítis
Trombocitopenia
Enfermedad de Crohn

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