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Vol. 28. Issue 2.
Pages 118-123 (April - June 2021)
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Vol. 28. Issue 2.
Pages 118-123 (April - June 2021)
Original Investigation
DOI: 10.1016/j.rcreue.2020.08.001
Therapeutic effects of Durian wood bark extract on a rat model of rheumatoid arthritis
Los efectos terapéuticos del extracto de corteza de madera durián en un modelo de rata de artritis reumatoide
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Zulvikar Syambani Ulhaqa,d,
Corresponding author
, Tenta Hartian Hendyatamab,d, Hamid Hunaif Dhofi Alluzac,d, Aulanni’am Aulanni’amd
a Department of Biochemistry, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim State Islamic University of Malang, Batu, East Java, Indonesia
b Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia
c Department of Urology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
d Department of Biochemistry, Faculty of Science, Brawijaya University, Malang, East Java, Indonesia
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Abstract
Background

Rheumatoid arthritis (RA) is a common immune-mediated inflammatory disease characterized by increased inflammation of synovial joint, and often associated with disability. Although several studies have demonstrated the medicinal properties of durian, little is known about the role of durian wood bark for medicinal purposes. Thus, this study investigated the anti-arthritic activity of durian wood bark extract in a rat model of rheumatoid arthritis.

Methods

The rats were divided into five groups, including control, RA model, and RA model treated with durian wood bark extract (20, 30, and 40mg/kg/day for 14 days). The effects of treatment were evaluated by clinical, as well as histological changes in the ankle joints, and the expression level of inducible nitric oxide synthase (iNOS).

Results

A complete Freund's adjuvant (CFA)-induced RA model in rats was successfully, characterized by the swelling of hind limbs, histopathological changes in ankle joints, and the upregulation of iNOS expression. The administration of durian wood bark extract at a dose of 40mg/kg attenuated all parameters analyzed in CFA-induced RA model in rats.

Conclusion

Amelioration of hind limb swelling, histopathological changes, and iNOS expression in the RA model indicates that durian wood bark extract can be considered as a new treatment alternative that reduces joint symptoms, as well as a future area of research in humans.

Keywords:
Rheumatoid arthritis
Durian wood bark extract
CFA-induced RA model
Resumen
Antecedentes

La artritis reumatoide (AR) es una enfermedad inflamatoria común mediada por el sistema inmunológico que se caracteriza por una mayor inflamación de la articulación sinovial, y a menudo se asocia con discapacidad. Aunque en varios estudios se han demostrado las propiedades medicinales del durián, se conoce poco sobre el papel de la corteza de madera de durián con fines médicos. Así pues, en este estudio se investigó la actividad antiartrítica del extracto de corteza de madera de durián en un modelo de AR en ratas.

Métodos

Las ratas se dividieron en 5 grupos, incluyendo el control, el modelo de AR y el modelo de AR tratado con extracto de corteza de madera durián (20, 30 y 40mg/kg/día durante 14 días). Los efectos del tratamiento se evaluaron mediante cambios clínicos e histológicos en las articulaciones de los tobillos y el nivel de expresión de la sintasa de óxido nítrico inducible (iNOS).

Resultados

Desarrollamos con éxito un modelo completo de AR inducida por adyuvantes de Freund (CFA) en ratas, caracterizado por la hinchazón de las extremidades posteriores, los cambios histopatológicos de las articulaciones del tobillo y el aumento de la expresión de la iNOS. La administración de extracto de corteza de madera de durián a una dosis de 40mg/kg atenuó todos los parámetros analizados en el modelo de AR inducida por CFA en ratas.

Conclusión

La mejora de la hinchazón de las extremidades traseras, los cambios histopatológicos y la expresión de iNOS en el modelo de AR indican que el extracto de corteza de madera dura puede considerarse una nueva alternativa de tratamiento para reducir los síntomas de las articulaciones, con un futuro campo de investigación en los seres humanos.

Palabras clave:
Artritis reumatoide
Extracto de corteza de madera de durián
Modelo de AR inducida por CFA

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