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Vol. 27. Issue S1.
Systemic Sclerosis
Pages 85-110 (April 2020)
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Vol. 27. Issue S1.
Systemic Sclerosis
Pages 85-110 (April 2020)
Review Article - Meta-analysis
DOI: 10.1016/j.rcreue.2020.01.001
Osteoarticular manifestations of systemic sclerosis: a systematic review of the literature
Manifestaciones osteoarticulares de esclerosis sistémica: una revisión sistemática de la literatura
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Molina-Rios Sebastiana,
Corresponding author
semolinar@gmail.com

Corresponding author.
, Ordoñez C. Elianaa, Quintana-Lopez Gerardoa,b
a Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia. Carrera 30 No. 45-03. Postal Code 111321, Bogota DC, Colombia
b REUMAVANCE Group, Rheumatology Section, Department of Internal Medicine, Fundación Santa Fe de Bogotá University Hospital. Carrera 7 No. 117-15. Postal Code 220246, Bogota DC, Colombia
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Tables (6)
Table 1. Articles included in the systematic review.
Table 2. Prevalence of OAM in SSc.
Table 3. Values of BMD, T scores and Z scores of patients with SSc.
Table 4. Radiographic changes in hands of patients with SSc.
Table 5. US changes in joints of patients with SSc.
Table 6. MRI changes in hands of patients with SSc.
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Abstract
Introduction

Osteoarticular manifestations (OAM) are frequently present in patients with systemic sclerosis (SSc). These OAM are related to important functional disability and a severe impact on patient’s life quality, therefore, they require special attention from clinicians.

Objective

Determining the frequency of reported OAM in SSc patients, the general impact of osteoarticular manifestations in patient’s condition and the tools available for diagnosis and treatment.

Methodology

A systematic review of the literature was performed for information published between January 1970 and December 2018 in the medical research databases of: Medline, Embase, Lilacs, Scielo, Cochrane and clinicaltrials.gov.

Results and Conclusions

A total of 116 articles were included in this review. The type and prevalence of the different OAM reported in the literature were determined. In addition to the evolution of their diagnostic methods, there are more validated methods to assess the impact of OAM in patients with SSc. Randomized clinical trials are required to establish the best treatment strategy for these patients.

Keywords:
Scleroderma
Systemic
Joints
Bone and Bones/complications
Quality of life
Systematic review.
Abbreviations:
OAM
SSc
RA
CRP
MCP
PIP
TFR
BMD
DEXA
TBS
Anti-CCP
ANA
Anti-dsDNA
Anti SCL-70
COMP
PAF-AH
HC Gp-39
SSc-RA
RF
DPT
US
MRI
HAQ
DI
SF-36
PCS
MCS
CHFS
HAMIS
HRQoL
DHI
DAS-28
SDAI
CDAI
IGF
SLE
Resumen
Introducción

Las manifestaciones osteoarticulares (MOA) están presentes de forma frecuente en pacientes con esclerosis sistémica (SSc). Generan gran discapacidad funcional con un impacto importante en la calidad de vida de los pacientes por lo que requieren especial atención por parte de los clínicos.

Objetivos

Determinar la frecuencia de las MOA dentro de la SSc, su impacto en la condición general de los pacientes, y las diferentes herramientas disponibles de diagnóstico y tratamiento.

Metodología

Se realizó una revisión sistemática de la literatura disponible desde enero de 1970 hasta diciembre de 2018, en las bases de datos de Medline, Embase, Lilacs, Scielo, Cochrane, y clinicaltrials.gov.

Resultados y conclusiones

Se incluyó un total de 116 artículos en esta revisión. Se determinó el tipo y la prevalencia de las diferentes manifestaciones osteoarticulares reportadas en la literatura. Además de la evolución en los métodos diagnósticos de las mismas, cada vez existen más métodos validados para evaluar el impacto de las MOA en los pacientes con SSC. Se requieren ensayos clínicos aleatorizados que permitan establecer la mejor estrategia de tratamiento para estos pacientes.

Palabras clave:
Esclerosis sistémica
Articulaciones
Compromiso óseo
Calidad de vida
Revisión sistemática.

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