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Original article
DOI: 10.1016/j.rcpeng.2017.06.002
Lifetime psychiatric disorders: A comparison study between offspring of parents with bipolar disorder type-I versus the offspring of community controls parents
Trastornos psiquiátricos a través de la vida: un estudio de comparación de hijos de padres con trastorno afectivo bipolar tipo I frente a hijos de padres controles de la comunidad
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Juan David Palacio-Ortiza,b,
Corresponding author
tdahcartagena@gmail.com

Corresponding author.
, Cristian Esteban Peña-Quinteroa, María Alejandra Gómez-Valeroa, Paula Andrea Bustamante-Gómeza, Pilar Helena Arroyave-Sierraa, Cristian David Vargas-Upeguía,b, Carlos López-Jaramilloa,b
a Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
b Programa de Trastornos del Ánimo, Hospital San Vicente Fundación, Medellín, Colombia
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Tables (5)
Table 1. Demographic characteristics and functionality of parents with bipolar disorder, biological co-parents and control parents.
Table 2. Comparison of psychiatric disorders between parents with bipolar disorder, biological co-parents and control parents.
Table 3. Demographic characteristics and functionality of children of parents with bipolar disorder and children of control parents.
Table 4. Comparison of psychiatric disorders according to the DSM-IV-RT among children of parents with bipolar disorder and children of control parents.
Table 5. Comparison of psychiatric disorders according to the DSM-IV-RT among children of parents with bipolar disorder and children of control parents by age group.
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Abstract
Introduction

Literature reports show that bipolar offspring (BO) present with a wide range of psychiatric disorders. Comparison between BO and control parent offspring (CPO) may help to identify which psychopathological findings are specific to this high-risk group.

Objective

To compare the psychopathological characteristics between a group of BO type-I and a group of CPO, by identifying the presence of psychiatric disorders according the DSM-IV-TR.

Methods

A descriptive-correlational, cross-sectional and comparative study was conducted with 127 offspring of parents with bipolar disorder type-I from the multimodal intervention programme (PRISMA) and with 150 CPO between 6 and 30 years of age. Subjects were evaluated with validated diagnostic interviews (K-SADS-PL and DIGS).

Results

The BO group showed higher frequencies for bipolar disorder (prevalence ratio [PR]=17.70; 95% confidence interval [CI]; 1.02–306.83), bipolar disorder not otherwise specified (PR=23.07, 95% CI; 2.8–189.0, p=0.0001), disorders due to psychoactive substance use (PR=9.52, 95% CI; 2.93–30.90), oppositional defiant disorder (PR=4.10, 95% CI; 1.70–9.89), posttraumatic stress disorder (PR=3.90, 95% CI 1.30–11.66), disorder due to alcohol use (PR=3.84, 95% CI; 1.28–11.48), attention deficit/hyperactivity disorder (PR=2.26, 95% CI; 1.37–3.75), and major depressive disorder (PR=2.25, 95% CI; 1.13–4.50). Statistically significant differences were also found in the CGAS and GAF functional scales, with lower scores for the BO group.

Conclusion

These findings confirm previous literature reports showing that BO have higher rates of affective and non-affective psychiatric disorders than control subjects, and also a lower level of global functioning.

Keywords:
Bipolar offspring
Psychopathology
High-risk
Children
Adolescent
Resumen
Introducción

Reportes en la literatura muestran que los Hijos de Padres con Trastorno Bipolar tipo I (HPTB) manifiestan un amplio rango de trastornos psiquiátricos. La comparación entre los HPTB y los Hijos de Padres Control (HPC) permite establecer cuáles hallazgos psicopatológicos son específicos de este grupo de alto riesgo.

Objetivo

Comparar las características psicopatológicas entre un grupo de HPTB tipo I y un grupo de HPC, mediante la identificación de la presencia de trastornos psiquiátricos según el DSM-IV-TR.

Metodología

Se realizó un estudio descriptivo-correlacional, comparativo de corte transversal con 127 Hijos de Padres con TAB tipo I (HPTB-I) dentro de un programa de intervención multimodal (PRISMA) y 150 HPC, con edades entre los seis y 30 años. Los sujetos fueron evaluados con entrevistas diagnósticas validados (K-SADS-PL y DIGS).

Resultados

El grupo de HPTB mostró mayor frecuencias de trastorno bipolar (Razón de Prevalencia [RP]=17,70; Intervalo de Confianza [IC] del 95%, 1,02-306,83), trastorno bipolar no especificado (RP=23,07, IC 95% 2,8 -189, p=0.0001), trastorno por uso de sustancias psicoactivas (RP=9,52; IC 95%, 2,93-30,90), trastorno oposicionista desafiante (RP=4,10; IC 95%, 1,70-9,89); trastorno de estrés postraumático (RP=3,90; IC 95%, 1,30-11,66), trastorno por uso de alcohol (RP=3,84; IC 95%, 1,2811,48), trastorno por déficit de atención e hiperactividad (RP=2,26; IC 95%, 1,37-3,75) y trastorno depresivo mayor (RP=2,25; IC 95%, 1,13-4,50). Tambien se encontraron diferencias estadisticamente significativas en las escalas de funcionalidad CGAS y GAF, con menor puntaje en el grupo de HPB.

Conclusión

Estos hallazgos confirman reportes previos de la literatura que demuestran que los HPTB presentan mayores tasas de trastornos psiquiatricos afectivos y no afectivos, y una menor nivel de funcionalidad global, al ser comparados con sujetos controles de la comunidad.

Palabras clave:
Hijos de pacientes bipolares
Psicopatología
Alto riesgo
Niños
Adolescentes

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