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Vol. 37. Issue 1.
Pages 29-39 (February - April 2009)
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Vol. 37. Issue 1.
Pages 29-39 (February - April 2009)
ACTUALIZACIONES E INNOVACIONES TECNOLO´GICAS
Open Access
Desarrollo de una aplicación informática para la administración de anestesia intravenosa
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Francisco Javier Gómez Oquendo
, Pedro Arango Castro**, Jorge Andrés Ruiz***, Juan Manuel Fernández***
* Profesor Asociado Servicio de Anestesia Universidad de Antioquia. Anestesiólogo IPS Universitaria
** Anestesiólogo Universidad de Antioquia
*** Bioingeniero Universidad de Antioquia
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RESUME
Objetivo

Desarrollar una aplicación informática para la administración de anestesia intravenosa en modo de concentración sitio efectivo

Método

Para lograr esto se implementan diferentes subsistemas: un modelo multicompartimental de distribución de fármacos en el cuerpo humano, un algoritmo para determinar la curva de velocidades a las que debe infundirse el anestésico propofol, para obtener el efecto de anestesia general, un protocolo de comunicación para enviar el vector de velocidades a una bomba de infusión convencional y la simulación de un lazo de realimentación para controlar todo el sistema a partir del índice bi-espectral que se utiliza como indicador de la profundidad de anestesia.

Resultado

Se crea un instrumento versátil, con Junciones similares a las de los equipos comerciales y con una interfaz interactiva, que facilita la operación por parte del anestesiólogo desde un computador convencional.

Conclusiones

Se ha implementado una herramienta informática dotada de un modelo farmacocinético multicompartimental de gran interés académico y clínico, que tal y como se ha demostrado deforma cuantitativa, proporciona idénticos resultados a los ofrecidos por equipos comerciales; con importantes ventajas adicionales como una interfaz de usuario interactiva y la posibilidad de administrar anestesia total intravenosa.

Palabras claves:
Propofol
farmacocinética
farmacodinamia
anestesia total intravenosa
SUMMARY
Objective

To develop a software for the administration of intravenous anesthesia in the mode of effective site concentration.

Methods

In order to achieve this, different subsystems are implemented: First, multi-compartment drug distribution model in the human body, an algorithm to determine the curve of speeds at which the anesthetic Propofol must be infused to obtain the effect of general anesthesia. Second, a communication protocol for sending the vector of speeds to a conventional infusión pump and finally, the simulation of a refeeding loop to control all the system starting with the bi-spectral index which is used as an indicator of the depth of the anesthesia.

Results

A versatile instrument is created, with similar services to those of the commercial equipments and with an interactive interface; same which makes the operation easier for the anesthesiologist from a conventional computer.

A software tool has been implemented and equipped with a multi-compartmental pharmacological model of great academic and clinical interest, which, as proved in a quantitative way, gives identical results as those offered by the commercial equipments. This brings important additional advantages as those of an interactive user interface as well as the possibility to administer total intravenous anesthesia.

Key words:
Propofol
pharmacokinetic
pharmacodynamics
total intravenous anesthesia. (TIVA)
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Tercer premio concurso Jorge Colmenares, XXVIII Congreso Colombiano de Anestesiología, marzo 2009, Bogotá

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