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Radiología (English Edition)

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Radiología (English Edition) What do we know about pseudocirrhosis? The role of the radiologist
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Update in Radiology
Available online 29 July 2026

What do we know about pseudocirrhosis? The role of the radiologist

¿Qué sabemos de la pseudocirrosis? El papel del radiólogo
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E. Canales Lachéna,
Corresponding author
canaleslachen@gmail.com

Corresponding author.
, M.Á. Gómez-Bermejoa, B. Mateos Muñozb, A. Salgado-Parentea, A. Villanueva Camposa
a Servicio de Radiodiagnóstico, Hospital Universitario Ramón y Cajal, Madrid, Spain
b Servicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
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Abstract

Pseudocirrhosis is a radiological diagnosis characterised by liver morphological alterations simulating cirrhosis in oncological patients, despite the absence of histopathological features of true cirrhosis. which relies almost entirely on imaging findings, carries important prognostic implications, as it is associated with increased morbidity and mortality, and a heightened risk of developing encephalopathy, oesophageal/gastric variceal bleeding, or hepatic failure. Nevertheless, despite its clinical relevance, many questions remain regarding its pathophysiology, predisposing factors, and optimal management.

In oncology patients with hepatic metastases, the presence of morphostructural liver changes such as surface retraction and nodularity, parenchymal atrophy, and/or hypertrophy of the caudate lobe should raise suspicion in the radiologist. This update aims to present current knowledge and the clinical relevance of this entity, highlighting its main clinical and imaging features.

Keywords:
Cirrhosis
Metastasis
Chemotherapy
Fibrosis
Liver disease
Neoplasms
Drug toxicity
Computer tomography
Resumen

La pseudocirrosis es un diagnóstico radiológico que refleja alteraciones morfológicas hepáticas que simulan la cirrosis en pacientes oncológicos, sin marcadores histopatológicos de cirrosis verdadera. Su diagnóstico, basado casi exclusivamente en pruebas de imagen, tiene una importante implicación pronóstica, ya que aumenta la morbimortalidad y el riesgo de desarrollar encefalopatía, hemorragia por varices esofágicas/gástricas o insuficiencia/fallo hepático. No obstante, a pesar de su trascendencia, todavía son muchos los interrogantes sobre la fisiopatología, los factores predisponentes y el manejo de esta entidad.

En el contexto de un paciente oncológico con metástasis hepáticas la presencia de alteraciones morfoestructurales hepáticas como la retracción y nodularidad de la superficie hepática, la atrofia parenquimatosa y/o la hipertrofia del lóbulo caudado deben poner en alerta al radiólogo.

Esta actualización tiene como objetivo presentar el conocimiento actual y la importancia de esta entidad, mostrando sus principales características clínicas y de imagen.

Palabras clave:
Cirrosis
Metástasis
Quimioterapia
Fibrosis
Hepatopatía
Neoplasias
Toxicidad farmacológica
Tomografía computarizada

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