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Medicina Clínica (English Edition) Criterion and non-criteria antiphospholipid antibodies and acute coronary syndro...
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Original article

Criterion and non-criteria antiphospholipid antibodies and acute coronary syndrome in the adult population under 55 years of age

Anticuerpos antifosfolípidos criterio y no criterio y síndrome coronario agudo en población adulta menor de 55 años
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Lourdes Villalobos-Sáncheza,
Corresponding author
lurdesvs@hotmail.com

Corresponding author.
, Sandra Garrote-Corrala, Irene Amil Casasb, Andrea Briones-Figueroaa, Patricia Morán-Alvareza, Antía García-Fernándeza, Ángela Carrasco Sayaleroc, Amalia Tejeda Velardec, Álvaro Lorente-Rosd, José Avendaño-Ortize, Asunción Camino Lópezd, Manuel Jiménez Menad, María Jesús García-Villanuevaa
a Department of Rheumatology, Ramón y Cajal University Hospital, Madrid, Spain
b Department of Ávila Health Center, Primary Care Management, Madrid, Spain
c Department of Immunology, Ramón y Cajal University Hospital. Madrid, Spain
d Department of Cardiology, Hospital Central de Asturias, Oviedo, Asturias, Spain
e Department of Microbiology, Ramón y Cajal University Hospital, Madrid, Spain
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Abstract
Objective

To determine the frequency of criterion and non-criterion antiphospholipid antibody (aPL) titers in young patients with acute coronary syndrome (ACS).

Method

A descriptive, prospective study with 12 weeks of follow-up was conducted in ACS patients under 55 years of age admitted to a tertiary hospital in Spain. The frequency of criterion and non-criterion aPL positivity was described in two determinations: at the time of diagnosis and at 12 weeks. A descriptive analysis of sociodemographic and clinical variables was performed, and the frequency of criterion and non-criterion aPL and antiphospholipid syndrome (APS) was estimated in these patients.

Results

A total of 52 patients with ACS were included. aPL positivity was found in 23% of the ACS patients; 3 patients met the Sydney criteria, and none met the new ACR criteria.

Conclusions

Antiphospholipid antibody positivity is common in patients with ACS.

Keywords:
Antiphospholipid antibodies
Acute coronary syndrome
Antiphospholipid syndrome
Resumen
Objetivo

Determinar la frecuencia de títulos de anticuerpos antifosfolípidos (aFL) criterio y no criterio en pacientes jóvenes con síndrome coronario agudo (SCA).

Método

Se ha llevado a cabo un estudio de descriptivo y prospectivo de 12 semanas de seguimiento en pacientes con SCA menores de 55 años ingresados en un hospital de tercer nivel de España. Se describió la frecuencia de positividad aFL criterio y no criterio en dos determinaciones, en el momento del diagnóstico y a las 12 semanas. Se ha realizado un análisis descriptivo de las variables sociodemográficas y clínicas, y se estimó la frecuencia de aFL criterio y no criterio y de SAF en estos pacientes.

Resultados

El total de pacientes incluidos fue 52 casos con SCA. Se encontró positividad de aFL en 23% de los pacientes con SCA, cumpliendo criterios de Sydney 3 pacientes y según los nuevos criterios ACR, ninguno.

Conclusiones

En los pacientes con SCA es frecuente encontrar positividad de aFL.

Palabras clave:
Anticuerpos antifosfolípidos
Síndrome coronario agudo
Síndrome antifosfolípido

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