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Inicio Medicina Clínica (English Edition) Alzheimer's disease: New therapeutic strategies
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Vol. 145. Issue 2.
Pages 76-83 (July 2015)
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Vol. 145. Issue 2.
Pages 76-83 (July 2015)
Review
Alzheimer's disease: New therapeutic strategies
Enfermedad de Alzheimer: nuevas estrategias terapéuticas
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33
Sandra Villegas
Protein Folding and Stability Group, Unitat de Biociències, Departament de Bioquímica i Biología Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain
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Table 1. Clinical trials in phases 2–4 with different approaches aimed at palliating and curing Alzheimer's disease.
Abstract

The rapid increase in prevalence rates of Alzheimer's disease means that treatments to prevent, stop or reverse this devastating disease are urgently needed. Despite advances in understanding its molecular pathology, there are no drugs that can halt its progression. This review takes a tour through phase 2, or higher studies, probing receptor agonist agents interfering with aggregation, inhibitors/modulators of secretases, lipid-lowering agents, and, finally and most extensively, immunotherapy. The fact that phase 3 studies with bapineuzumab and solaneuzumab have recently failed does not invalidate the potential of immunotherapy, as more information is available and new clinical trials are being initiated.

Keywords:
Alzheimer's disease
New therapies
Immunotherapy
Vaccine
Amyloid-β
Resumen

El rápido aumento de las tasas de prevalencia de la enfermedad de Alzheimer hace que se necesiten con urgencia tratamientos dirigidos a prevenir, detener o revertir esta devastadora enfermedad. A pesar de los avances en la comprensión de su patología molecular, todavía no existen fármacos que puedan detener su progresión. Esta revisión hace un recorrido por aquellos estudios en fase 2, o superior, que ensayan agonistas de receptores, sustancias que interfieren en la agregación, inhibidores/moduladores de las secretasas, hipolipidemiantes, y, finalmente y con mayor extensión, las inmunoterapias. El hecho de que recientemente hayan fallado las fases 3 para bapineuzumab y solaneuzumab no invalida el potencial de la inmunoterapia, ya que cada vez disponemos de más información y se están iniciando nuevos ensayos clínicos.

Palabras clave:
Enfermedad de Alzheimer
Nuevos tratamientos
Inmunoterapia
Vacuna
β-Amiloide

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