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Inicio Gastroenterología y Hepatología (English Edition) Role of altered immune cells in liver diseases: a review
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Vol. 41. Issue 6.
Pages 353-422 (June - July 2018)
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Vol. 41. Issue 6.
Pages 353-422 (June - July 2018)
REVIEW
DOI: 10.1016/j.gastre.2018.01.003
Role of altered immune cells in liver diseases: a review
Revisión sobre el papel de los inmunocitos alterados en las enfermedades hepáticas
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Braira Wahida,b, Amjad Alib, Shazia Rafiqueb, Komal Saleema,b, Muhammad Waqara,b, Muhammad Wasimc, Muhammad Idreesa,b,c,d,e,
Corresponding author
idrees.khan96@yahoo.com

Corresponding author. CEO, Genome Centre for Molecular Based Diagnostics and Research, Al-Sudais Plaza Abdalian Cooperative Society, Lahore Pakistan. Tel.: +92 42 35219020.
a Centre for Applied Molecular Biology (CAMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan
b Genome Centre for Molecular Based Diagnostics and Research, Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan
c Department of Medicine, Khyber Teaching Hospital Peshawar KPK, Pakistan
d Division of Molecular Virology and Diagnostics Center of Excellence in Molecular Biology (CEMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan
e Vice Chancellor Hazara University Mansehra, Pakistan
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Table 1. Function of NK and NKT cells in liver diseases.58
Abstract

Immune cells play an important role in controlling liver tumorigenesis, viral hepatitis, liver fibrosis and contribute to pathogenesis of liver inflammation and injury. Accumulating evidence suggests the effectiveness of natural killer (NK) cells and Kupffer cells (KCs) against viral hepatitis, hepatocellular damage, liver fibrosis, and carcinogenesis. Activation of natural killer cells provides a novel therapeutic strategy to cure liver related diseases. This review discusses the emerging roles of immune cells in liver disorders and it will provide baseline data to scientists to design better therapies for treatment.

Keywords:
Liver
Cirrhosis
NK Cells
Dendritic cells
Hepatic stellate cells
Resumen

Los inmunocitos o células inmunitarias desempeñan un papel importante en el control de la carcinogénesis hepática, la hepatitis vírica, la fibrosis hepática y contribuyen a la patogénesis de la inflamación y la lesión hepáticas. La creciente evidencia sugiere la efectividad de los linfocitos citolíticos naturales (NK, natural killer) y las células de Kupffer (KC, Kupffer cells) frente a la hepatitis vírica, la lesión hepatocelular, la fibrosis hepática y la carcinogénesis. La activación de linfocitos citolíticos naturales ofrece una nueva estrategia terapéutica para curar enfermedades relacionadas con el hígado. Esta revisión trata de las nuevas funciones de los inmunocitos en los trastornos hepáticos y ofrecerá datos básicos a los científicos para diseñar mejores terapias para el tratamiento.

Palabras clave:
Hígado
Cirrosis
Células NK
Células dendríticas
Células de Kupffer

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