Regístrese
Buscar en
Gastroenterología y Hepatología (English Edition)
Toda la web
Inicio Gastroenterología y Hepatología (English Edition) Progress in diagnosis and surgical treatment of perihilar cholangiocarcinoma
Journal Information
Vol. 42. Issue 4.
Pages 271-279 (April 2019)
Share
Share
Download PDF
More article options
ePub
Visits
0
Vol. 42. Issue 4.
Pages 271-279 (April 2019)
Review
DOI: 10.1016/j.gastre.2019.03.005
Progress in diagnosis and surgical treatment of perihilar cholangiocarcinoma
Avances en el diagnóstico y tratamiento quirúrgico del colangiocarcinoma perihiliar
Visits
0
Jia-Wei Feng, Xing-Hai Yang, Bao-Qiang Wu, Yong Jiang
Corresponding author
yjiang8888@hotmail.com

Corresponding authors.
, Zhen Qu
Corresponding author
quzhen5014@126.com

Corresponding authors.
The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, Department of Hepatopancreatobiliary Surgery, Changzhou, Jiangsu, China
This item has received
0
Visits
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (2)
Table 1. Comparison of different examinations.
Table 2. Comparison of different classification systems.
Show moreShow less
Abstract

Cholangiocarcinomas are heterogeneous biliary tract tumors that cause devastating disease. Perihilar cholangiocarcinoma (PHC) is the most common type of biliary tract cancer and are associated with a high mortality. Diagnoses of PHC depend on the results of its clinical presentation, serum biomarkers and imaging techniques. Pre-operative managements including pre-operative biliary drainage (PBD) and portal vein embolization (PVE) could reduce mortality. The best chance of long-term survival and potential cure is surgical resection with negative surgical margin. Lymph node metastasis over N2 nodes precludes long-term survival. The benefit of concomitant vascular resection remains uncertain. Liver transplantation combined with neoadjuvant chemotherapy with radiotherapy is a promising option in highly selected patients with unresectable tumors. Herein, an overview is provided of developments in diagnosis, peri-operative management and surgical treatment among patients with PHCs.

Keywords:
Perihilar cholangiocarcinoma
Diagnosis
Surgical resection
Review
Abbreviations:
PHC
PBD
PVE
CCAs
PSC
CA19-9
CEA
HRCT
MRI
MRCP
LN
ERCP
PTC
FISH
EUS
FNA
AJCC
TNM
FLR
PTBD
ENBD
ERBD
ALPPS
R-H
L-H
PVR
HAR
EBRT
Resumen

Los colangiocarcinomas son tumores heterogéneos de las vías biliares, que provocan enfermedades graves. El colangiocarcinoma perihiliar (CPH) es el tipo más frecuente de cáncer de las vías biliares y se asocia con elevada mortalidad. El tipo de diagnóstico del CPH depende de los efectos de la presentación clínica, los biomarcadores séricos y las técnicas de diagnóstico por la imagen. Los tratamientos preoperatorios, entre los cuales se encuentran el drenaje biliar preoperatorio (DBP) y la embolización de la vena porta (EVP), podrían reducir la mortalidad. La mejor opción para lograr una supervivencia a largo plazo y la posible curación es la resección quirúrgica con borde quirúrgico negativo. La metástasis ganglionar N2 impide la supervivencia a largo plazo. El beneficio de la resección vascular concomitante continúa siendo incierto. El trasplante de hígado combinado con quimiorradioterapia prequirúrgica es una opción prometedora en pacientes cuidadosamente seleccionados con tumores inoperables. En este documento ofrecemos una visión general del desarrollo que se ha producido en el diagnóstico, el tratamiento perioperatorio y el tratamiento quirúrgico de pacientes con CPH.

Palabras clave:
Colangiocarcinoma perihiliar
Diagnóstico
Resección quirúrgica
Revisión

Article

These are the options to access the full texts of the publication Gastroenterología y Hepatología (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Gastroenterología y Hepatología (English Edition)

Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.