Buscar en
Gastroenterología y Hepatología (English Edition)
Toda la web
Inicio Gastroenterología y Hepatología (English Edition) NSAIDs, gastrointestinal toxicity and inflammatory bowel disease
Journal Information
Vol. 45. Issue 3.
Pages 215-222 (March 2022)
Share
Share
Download PDF
More article options
ePub
Visits
0
Vol. 45. Issue 3.
Pages 215-222 (March 2022)
Review
NSAIDs, gastrointestinal toxicity and inflammatory bowel disease
AINEs, toxicidad gastrointestinal y enfermedad inflamatoria intestinal
Visits
...
Gonzalo Hijos-Malladaa,b,
Corresponding author
gonzahijos@gmail.com

Corresponding author.
, Carlos Sostresa,b, Fernando Gomollóna,b,c
a Servicio de Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
b Instituto de Investigación Sanitaria (ISS) Aragón, Zaragoza, Spain
c Departamento de Medicina, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Tables (3)
Table 1. Mechanisms of gastrointestinal toxicity of NSAIDs independent of COX inhibition.
Table 2. Risk factors for upper gastrointestinal damage associated with NSAIDs.
Table 3. Clinical manifestations of damage to the lower digestive tract caused by NSAIDs.
Show moreShow less
Abstract

Non-steroidal antiinflammatory drugs (NSAIDs) are currently one of the most widely used drugs. The use of NSAIDs is associated with gastrointestinal toxicity, affecting both upper gastrointestinal tract (peptic ulcer disease) and lower gastrointestinal tract (NSAID induced enteropathy).

NSAIDs use has been associated with an increased risk of clinical relapse in inflammatory bowel disease (IBD) patients. In this article, we review the upper and lower gastrointestinal toxicity of NSAIDs, with a focus on the risks and specific data of these drugs in IBD patients, giving recommendations for its appropriate use in clinical practice. Although evidence is scarce, short-term use of NSAIDs appears to be safe, and the data available suggest that selective COX-2 inhibitors are the safer option. NSAIDs should be avoided as long-term treatment or with high doses, especially in patients with active inflammation.

Keywords:
Inflammatory bowel disease
Crohn's disease
Ulcerative colitis
Nonsteroidal antiinflammatory drugs
Enteropathy
Peptic ulcer
Resumen

Los antiinflamatorios no esteroideos (AINEs) son uno de los grupos de fármacos más frecuentemente utilizados en la actualidad. El uso de AINEs implica riesgo de toxicidad gastrointestinal, pudiendo afectar tanto al tracto superior (úlcera péptica) como al inferior (gastroenteropatía por AINEs).

La toma de AINEs se ha relacionado con un empeoramiento clínico en pacientes con enfermedad inflamatoria intestinal (EII). En este artículo realizamos una revisión acerca de la toxicidad gastrointestinal alta y baja de los AINEs, centrándonos especialmente en los riesgos y datos característicos de estos fármacos en pacientes con EII, estableciendo recomendaciones para su uso en la práctica clínica. Aunque la evidencia es limitada, pautas cortas a dosis bajas de AINEs parecen seguras, y los datos sugieren que los inhibidores selectivos de la COX-2 son la opción más segura. Se debe evitar su uso a largo plazo o a dosis altas, especialmente en pacientes con inflamación activa.

Palabras clave:
Enfermedad inflamatoria intestinal
Enfermedad de Crohn
Colitis ulcerosa
Antiinflamatorios no esteroideos
Enteropatía
Úlcera péptica

Article

These are the options to access the full texts of the publication Gastroenterología y Hepatología (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Gastroenterología y Hepatología (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos