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Original article
Diagnostic accuracy of the Spanish version of the 4AT scale (4AT-ES) for delirium screening in older inpatients
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E. Delgado-Paradaa,b,
Corresponding author
eduardo.delgado@salud.madrid.org

Corresponding author at: Department of Psychiatry, Hospital Universitario de La Princesa, Diego de León St, 62, Madrid 28006, Spain.
, D. Morillo-Cuadradob,c, J Saiz-Ruizc,d,e, A. Cebollada-Graciad,e, J.L. Ayuso-Mateosa,b,c, A.J. Cruz-Jentofte,f
a Department of Psychiatry, Hospital Universitario de La Princesa, Diego de León St, 62, Madrid 28006, Spain
b Instituto de Investigación Sanitaria Hospital Universitario de la Princesa (IIS-Princesa), c/ Diego de León, 62, Madrid 28006, Spain
c Network-based Biomedical Research Consortium, area of Mental Health (CIBERSAM), Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, Madrid 28029, Spain
d Department of Psychiatry. Hospital Universitario Ramon y Cajal, Ctra. de Colmenar Viejo km. 9,100, Madrid 28034, Spain
e Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS) Ctra. de Colmenar Viejo, Km. 9,100. Planta - 2 derecha Madrid 28034, Spain
f Department of Geriatrics. Hospital Universitario Ramón y Cajal. Ctra. de Colmenar Viejo km. 9, 100,. Madrid 28034, Spain
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Received 30 September 2021. Accepted 12 January 2022
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Table 1. Spanish version of the 4AT scale (4AT-ES).
Abstract
Background and objectives

The 4AT scale is a sensitive tool for screening delirium, which can be applied rapidly in clinical settings without any specific training. It has not been translated, adapted, and validated to assess Spanish older adults. The aims of the study are: to translate and adapt to Spanish culture the 4AT scale, to present evidence of the diagnostic accuracy of this version (4AT-ES) when applied in non-specialized hospital wards, and to assess the loss of diagnostic accuracy in presence of risk factors.

Methods

A prospective sample was independently assessed on the 4AT-ES and the reference standard. One hundred and twenty-one inpatients (70+ years) for whom a psychiatric assessment was requested were included. Out of them, 50 were diagnosed with delirium. Nurses without specific training applied the 4AT-ES, and experienced psychiatrists cast the reference standard diagnosis (DSM-V criteria).

Results

Patients with delirium were older and had more risk factors (more previous delirium episodes, a higher likelihood of prior dementia/cognitive impairment) than controls. The 4AT-ES had excellent validity, sensitivity (96%) , and specificity (83.1%). The area under the curve was 0.918; in the subsample with any of those risk factors, its value did not decrease.

Conclusion

The 4AT-ES version of the 4AT scale was developed. When applied by non-specifically trained, nursing staff it showed excellent validity, sensitivity, and specificity, even in a subsample with previous risk factors. All indices were comparable to the original version. We recommend its use for efficient delirium screening in hospitalized older patients with suspected delirium.

Keywords:
Delirium screening
Translation
Diagnostic accuracy
Validation

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