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Inicio Enfermedades Infecciosas y Microbiología Clínica (English Edition) In vitro activity of ceftaroline in combination with other antimicrobials active...
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1979
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In vitro activity of ceftaroline in combination with other antimicrobials active against Staphylococcus spp.
Actividad in vitro de la combinación de ceftarolina con otros antimicrobianos activos frente a Staphylococcus spp.
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1979
Yolanda Gil Romeroa,
Corresponding author
yolandagil2001@yahoo.es

Corresponding author.
, José-Luis Gómez-Garcésb
a Servicio de Microbiología, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain
b Instituto de Investigación Biomédica, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain
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Received 07 November 2018. Accepted 12 March 2019
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Tables (2)
Table 1. Ranges of MIC and MIC50 (mg/l) of ceftaroline, daptomycin, vancomycin and linezolid in 70 clinically significant isolates of Staphylococcus spp.
Table 2. Synergistic, additive and indifferent effects on ceftaroline combinations for 70 clinically significant strains of Staphylococcus spp.
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Abstract
Introduction

We evaluated the in vitro activity of the combination of ceftaroline with daptomycin, linezolid and vancomycin against methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus (CNS).

Material and methods

We analysed 70 staphylococcal strains (31 S. aureus and 39 CNS) with the Etest using the MIC:MIC ratio method and calculation of fractional inhibitory concentration indexes.

Results

The combination of ceftaroline with daptomycin showed an additive effect (53.2%) and synergy (6.6%) against methicillin-susceptible S. aureus, and an additive effect (81.2%) against methicillin-resistant S. aureus (MRSA). This combination also showed an additive effect against 33% of linezolid-susceptible CNS and was not synergistic against linezolid-resistant CNS. The combination of ceftaroline with vancomycin was synergistic (87%) and ceftaroline with linezolid was additive (37%) against MRSA.

Conclusions

The combinations of ceftaroline with daptomycin, vancomycin or linezolid showed additive and/or synergistic effects against methicillin-resistant Staphylococcus.

Keywords:
Ceftaroline
Synergies
Staphylococci
Resumen
Introducción

Evaluamos la actividad in vitro de la combinación de ceftarolina con daptomicina, linezolid y vancomicina frente a aislados de Staphylococcus aureus (S. aureus) y Staphylococcus coagulasa negativa (SCN) resistentes a meticilina.

Material y métodos

Se analizaron 70 cepas de estafilococos (31 S. aureus y 39 SCN) utilizando el método de CMI:CMI ratio con Etest y cálculo de los índices de concentración inhibitoria fraccionaria.

Resultados

La combinación de ceftarolina con daptomicina resultó aditiva (53,2%) y sinérgica (6,6%) frente a S. aureus sensibles a meticilina y aditiva (81,2%) frente a S. aureus resistentes a meticilina (SARM). También resultó aditiva frente al 33% de SCN sensibles a linezolid y no hubo sinergia frente a SCN resistentes a linezolid. Ceftarolina con vancomicina mostró sinergia (87%) y ceftarolina con linezolid adición (37%) frente a SAMR.

Conclusiones

Las combinaciones de ceftarolina con daptomicina, vancomicina o linezolid presentan efectos aditivos o sinérgicos frente a Staphylococcus resistentes a meticilina.

Palabras clave:
Ceftarolina
Sinergias
Estafilococos

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