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Vol. 39. Issue 4.
Pages 168-173 (April 2021)
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Vol. 39. Issue 4.
Pages 168-173 (April 2021)
Original article
DOI: 10.1016/j.eimce.2020.04.007
Molecular characteristics of drug-resistance Mycobacterium tuberculosis strains isolated from extra pulmonary tuberculosis sites
Características moleculares de cepas de Mycobacterium tuberculosis farmacorresistentes aisladas de los sitios de tuberculosis extrapulmonar
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Tongxin Lia, Tao Shib,
Corresponding author
shitaostone@163.com

Corresponding author.
, Ying Sunc, Fei Chend, Wenxue Jiangb, Yaokai Chena
a Central Laboratory, Chongqing Public Health Medical Center, Chongqing, China
b Department of Orthopedics, Tianjin First Center Hospital, Tianjin, China
c Department of Respiratory, Tianjin Hexi Hospital, Tianjin, China
d Department of Orthopedics, Bozhou District People's Hospital, Zunyi City, Guizhou Province, China
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Tables (4)
Table 1. Demographic characteristics of 162 patients with DR-EPTB.
Table 2. Correlations between genotypes and patterns of DR, history of treatment and gender (n=162).
Table 3. Correlations between history of treatment and patterns of DR, gender (n=162).
Table 4. Correlations between patterns of DR and gender (n=162).
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Abstract
Objectives

China is the second high tuberculosis (TB) burden country in the world. This article was to determinate the molecular characteristic of drug resistance Mycobacterium tuberculosis (DRTB) strains from extra pulmonary tuberculosis (EPTB).

Methods

The medical records of patients with EPTB were reviewed and collected from 2006 to 2016. The drug sensitivity of all samples was studied. All multiple drug resistance (MDR) and extensive drug resistance (XDR) strains were included. The detection of the deletion of region of difference 105 (RD105) and mycobacterial interspersed repetitive-unit variable-number tandem-repeat (MIRU-VNTR) were used to discriminate the molecular type of EPTB strains.

Results

162 DRTB isolates were from patients with EPTB including 104 male and 58 female. Beijing genotype had a significant correlation with the patterns of DR (P<0.05), re-treatment patients (P<0.05) and gender (P<0.05). The history of treatment had a statistically significant correlation with patterns of DR (P<0.05) and gender (P<0.05). Patterns of DR had no correlation with gender (P>0.05). Of 162 strains Beijing family strains represented 91.4%. The cluster rate was 17.9% and clustering ratio was 11.1%. Beijing family genotype is predominant in the patients with EPTB. The cluster rate and clustering ratio was low.

Conclusions

Beijing family genotype is predominant and highly epidemic in the patients with drug resistance extra pulmonary tuberculosis (DR-EPTB). The cluster rate and clustering ratio was low. Genotype of re-treatment male patient with DR-EPTB is more likely Beijing family genotype.

Keywords:
Extra pulmonary tuberculosis
Multiple drug resistance
Extensive drug resistance
Molecular characteristics
Chongqing
Resumen
Objetivos

China es el país con la segunda mayor carga de tuberculosis (TB) del mundo. Este artículo pretende determinar las características moleculares de cepas de Mycobacterium tuberculosis farmacorresistentes (MBFR) en la tuberculosis extrapulmonar (TBEP).

Métodos

Se revisaron y recopilaron los registros médicos de pacientes con TBEP entre 2006 y 2016. Se estudió la sensibilidad farmacológica de todas las muestras. Se incluyeron todas las cepas con farmacorresistencia múltiple (FRM) y farmacorresistencia extensiva (FRE). Para discriminar el tipo molecular de las cepas de TBEP se utilizó la detección de la eliminación de la región de diferencia 105 (RD105) y las repeticiones en tándem con número variable de unidades repetitivas interespaciadas de micobacterias (MIRU-VNTR).

Resultados

Ciento sesenta y dos aislados de pacientes con TBEP, de los cuales 104 eran varones y 58 mujeres. El genotipo de Beijing tuvo una correlación significativa con los patrones de FR (p<0,05), pacientes con retratamiento (p<0,05) y sexo (p<0,05). Los antecedentes de tratamiento tuvieron una correlación estadísticamente significativa con los patrones de FR (p<0,05) y sexo (p<0,05). Los patrones de FR no tuvieron correlación con el sexo (p<0,05). Del total de las 162 cepas, las cepas de Beijing representaron el 91,4%. La tasa de agrupamiento fue del 17,9% y la proporción de agrupamiento del 11,1%. El genotipo de Beijing es predominante en los pacientes con TBEP. La tasa de agrupamiento y la proporción de agrupamiento fueron bajas.

Conclusiones

El genotipo de Beijing es predominante y altamente epidémico en los pacientes con tuberculosis extrapulmonar farmacorresistente (TBEP-FR). La tasa de agrupamiento y la proporción de agrupamiento fueron bajas. El genotipo de paciente varón con TBEP-FR retratado es más probable en el genotipo de la familia de Beijing.

Palabras clave:
Tuberculosis extrapulmonar
Farmacorresistente múltiple
Farmacorresistencia extensiva
Características moleculares
Chongqing

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